Cell. 2016 Dec 15;167(7):1672-1674. doi: 10.1016/j.cell.2016.11.050.

Bursts of Reprogramming: A Path to Extend Lifespan?

Author information

1: Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.
2: Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA; Glenn Laboratories for the Biology of Aging, Stanford University, Stanford, CA 94305, USA. Electronic address: anne.brunet@stanford.edu.

Abstract

In a thought-provoking study, Ocampo et al. show that the cyclic expression of stem cell reprogramming factors in vivo increases the lifespan of a mouse model of premature aging and provides health benefits to chronologically old, normal mice.