This new digital fluorography processing method of matched filtering generates a set of images that have been acquired at continuous video-frame rates (30 per second) over the temporal extent of the bolus (10 seconds), and it combines them to produce the equivalent of a single digital subtraction angiography (DSA) image. Because of the extensive temporal averaging used, the method can provide substantial x-ray exposure reduction per run as compared with conventional techniques for an equivalent signal-to-noise ratio in the final image. The matched filtering technique was compared with conventional pulsed (one per second) DSA images of both extracranial and intracranial arteries, and the results are presented. Matched filtered images provided image quality that was equivalent to that of conventional DSA images at about one-fourth the patient exposure per run for both carotid artery and cerebral vessel studies. Despite long integration times, patient motion irretrievably corrupted image quality in only two of five carotid artery studies and in none of three intracranial studies. Compensation for patient motion is demonstrated, and additional applications and limitations of the technique are discussed.