Joshua W. Knowles

Publications

• Familial Hypercholesterolemia and the 2013 American College of Cardiology/American Heart Association Guidelines: Myths, Oversimplification, and Misinterpretation Versus Facts
  Knowles, J. W., Stone, N. J., & Ballantyne, C. M. (2015). Familial Hypercholesterolemia and the 2013 American College of Cardiology/American Heart Association Guidelines: Myths, Oversimplification, and Misinterpretation Versus Facts. AMERICAN JOURNAL OF CARDIOLOGY, 116(3), 481-484.
• Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes
  Fall, T., Xie, W., Poon, W., Yaghootkar, H., Maegi, R., & Ingelsson, E. (2015). Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes. DIABETES, 64(7), 2676-2684.
• Systematic Comparison of Digital Electrocardiograms From Healthy Athletes and Patients With Hypertrophic Cardiomyopathy.
  Bent, R. E., Wheeler, M. T., Hadley, D., Knowles, J. W., Pavlovic, A., & Perez, M. V. (2015). Systematic Comparison of Digital Electrocardiograms From Healthy Athletes and Patients With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 65(22), 2462-2463.
• Prevalence and Prognostic Role of Right Ventricular Involvement in Stress-Induced Cardiomyopathy Finocchiaro, G., Kobayashi, Y., Magavern, E., Zhou, J. Q., Ashley, E., & Tremmel, J. A. (2015). Prevalence and Prognostic Role of Right Ventricular Involvement in Stress-Induced Cardiomyopathy. JOURNAL OF CARDIAC FAILURE, 21(5), 419-425.
  
• Cardiopulmonary responses and prognosis in hypertrophic cardiomyopathy: a potential role for comprehensive noninvasive hemodynamic assessment. Finocchiaro, G., Haddad, F., Knowles, J. W., Caleshu, C., Pavlovic, A., & Ashley, E. A. (2015). Cardiopulmonary responses and prognosis in hypertrophic cardiomyopathy: a potential role for comprehensive noninvasive hemodynamic assessment. JACC. Heart failure, 3(5), 408-418.
  
• Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene Knowles, J. W., Xie, W., Zhang, Z., Chennemsetty, I., Assimes, T. L., & Quertermous, T. (2015). Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. JOURNAL OF CLINICAL INVESTIGATION, 125(4), 1739-1751.
  
• PCSK9 Inhibition: Current Concepts and Lessons from Human Genetics Rodriguez, F., & Knowles, J. W. (2015). PCSK9 Inhibition: Current Concepts and Lessons from Human Genetics. CURRENT ATHEROSCLEROSIS REPORTS, 17(3).
  
• Genetic Evidence for a Normal-Weight "Metabolically Obese" Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes Yaghootkar, H., Scott, R. A., White, C. C., Zhang, W., Speliotes, E., & Frayling, T. M. (2014). Genetic Evidence for a Normal-Weight "Metabolically Obese" Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes. DIABETES, 63(12), 4369-4377.
  
• Hyperuricaemia: the unintended consequence of insulin resistance/compensatory hyperinsulinaemia. Philanthropy gone awry. Knowles, J. W., & Reaven, G. (2014). Hyperuricaemia: the unintended consequence of insulin resistance/compensatory hyperinsulinaemia. Philanthropy gone awry. Journal of internal medicine, 276(2), 196-198.
  
• Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity Dimas, A. S., Lagou, V., Barker, A., Knowles, J. W., Maegi, R., & Prokopenko, I. (2014). Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity. DIABETES, 63(6), 2158-2171.
  
• Re: "Temporal relationship between uric acid concentration and risk of diabetes in a community-based study population". Knowles, J. W., & Reaven, G. (2014). Re: "Temporal relationship between uric acid concentration and risk of diabetes in a community-based study population". American journal of epidemiology, 179(9), 1147-1148.
  
• Latent Obstruction and Left Atrial Size Are Predictors of Clinical Deterioration Leading to Septal Reduction in Hypertrophic Cardiomyopathy Finocchiaro, G., Haddad, F., Pavlovic, A., Sinagra, G., Schnittger, I., & Ashley, E. (2014). Latent Obstruction and Left Atrial Size Are Predictors of Clinical Deterioration Leading to Septal Reduction in Hypertrophic Cardiomyopathy. JOURNAL OF CARDIAC FAILURE, 20(4), 236-243.
  
• Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry. O'Brien, E. C., Roe, M. T., Fraulo, E. S., Peterson, E. D., Ballantyne, C. M., & Knowles, J. W. (2014). Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry. American heart journal, 167(3), 342-349 e17.
  
• Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry O'Brien, E. C., Roe, M. T., Fraulo, E. S., Peterson, E. D., Ballantyne, C. M., & Knowles, J. W. (2014). Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry. AMERICAN HEART JOURNAL, 167(3), 342-?.
  
• Unexplained Double-Chambered Left Ventricle Associated with Contracting Right Ventricular Aneurysm and Right Atrial Enlargement Finocchiaro, G., Murphy, D., Pavlovic, A., Haddad, F., Shiran, H., & Knowles, J. W. (2014). Unexplained Double-Chambered Left Ventricle Associated with Contracting Right Ventricular Aneurysm and Right Atrial Enlargement. ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 31(3), E80-E84.
  
• Unexplained double-chambered left ventricle associated with contracting right ventricular aneurysm and right atrial enlargement. Finocchiaro, G., Murphy, D., Pavlovic, A., Haddad, F., Shiran, H., & Knowles, J. W. (2014). Unexplained double-chambered left ventricle associated with contracting right ventricular aneurysm and right atrial enlargement. Echocardiography (Mount Kisco, N.Y.), 31(3), E80-4.
  
• Prevalence and Clinical Correlates of Right Ventricular Dysfunction in Patients With Hypertrophic Cardiomyopathy Finocchiaro, G., Knowles, J. W., Pavlovic, A., Perez, M., Magavern, E., & Ashley, E. A. (2014). Prevalence and Clinical Correlates of Right Ventricular Dysfunction in Patients With Hypertrophic Cardiomyopathy. AMERICAN JOURNAL OF CARDIOLOGY, 113(2), 361-367.
  
• How does morphology impact on diastolic function in hypertrophic cardiomyopathy? A single centre experience. Finocchiaro, G., Haddad, F., Pavlovic, A., Magavern, E., Sinagra, G., & Ashley, E. A. (2014). How does morphology impact on diastolic function in hypertrophic cardiomyopathy? A single centre experience. BMJ open, 4(6).
  
• How does morphology impact on diastolic function in hypertrophic cardiomyopathy? A single centre experience Finocchiaro, G., Haddad, F., Pavlovic, A., Magavern, E., Sinagra, G., & Ashley, E. A. (2014). How does morphology impact on diastolic function in hypertrophic cardiomyopathy? A single centre experience. BMJ OPEN, 4(6).
  
• Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example. Goldstein, B. A., Knowles, J. W., Salfati, E., Ioannidis, J. Pa., & Assimes, T. L. (2014). Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example. Frontiers in genetics, 5, 254-?.
  
• Trans-ethnic fine mapping identifies a novel independent locus at the 3 ' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population Kuo, J. Z., Sheu, W. H.-H., Assimes, T. L., Hung, Y.-J., Absher, D., & Chen, Y.-D. I. (2013). Trans-ethnic fine mapping identifies a novel independent locus at the 3 ' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population. DIABETOLOGIA, 56(12), 2619-2628.
  
• Variation in Use of Left Ventriculography in the Veterans Affairs Health Care System Heidenreich, P. A., Lin, S., Knowles, J. W., Perez, M., Maddox, T. M., & Witteles, R. M. (2013). Variation in Use of Left Ventriculography in the Veterans Affairs Health Care System. CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 6(6), 687-693.
  
• Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes Yaghootkar, H., Lamina, C., Scott, R. A., Dastani, Z., Hivert, M.-F., & Frayling, T. M. (2013). Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes. DIABETES, 62(10), 3589-3598.
  
• Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. Coram, M. A., Duan, Q., Hoffmann, T. J., Thornton, T., Knowles, J. W., & Tang, H. (2013). Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. American journal of human genetics, 92(6), 904-916.
  
• Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations Coram, M. A., Duan, Q., Hoffmann, T. J., Thornton, T., Knowles, J. W., & Tang, H. (2013). Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations. AMERICAN JOURNAL OF HUMAN GENETICS, 92(6), 904-916.
  
• Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. Jjm., Peal, D. S., & Loos, R. Jf. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature genetics, 45(6), 621-631.
  
• Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders Den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. Jjm., Peal, D. S., & Loos, R. Jf. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. NATURE GENETICS, 45(6), 621-?.
  
• Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes Xie, W., Wood, A. R., Lyssenko, V., Weedon, M. N., Knowles, J. W., & Walker, M. (2013). Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes. DIABETES, 62(6), 2141-2150.
  
• Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Liang, P., Lan, F., Lee, A. S., Gong, T., Sanchez-Freire, V., & Wu, J. C. (2013). Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation, 127(16), 1677-1691.
  
• Drug Screening Using a Library of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity Liang, P., Lan, F., Lee, A. S., Gong, T., Sanchez-Freire, V., & Wu, J. C. (2013). Drug Screening Using a Library of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity. CIRCULATION, 127(16), 1677-?.
  
• Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp Knowles, J. W., Assimes, T. L., Tsao, P. S., Natali, A., Mari, A., & Abbasi, F. (2013). Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp. METABOLISM-CLINICAL AND EXPERIMENTAL, 62(4), 548-553.
  
• Role of international registries in enhancing the care of familial hypercholesterolaemia. Hammond, E., Watts, G. F., Rubinstein, Y., Farid, W., Livingston, M., & Dawkins, H. J. (2013). Role of international registries in enhancing the care of familial hypercholesterolaemia. International journal of evidence-based healthcare, 11(2), 134-9.
  
• Large-scale association analysis identifies new risk loci for coronary artery disease Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., & Samani, N. J. (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. NATURE GENETICS, 45(1), 25-U52.
  
• Large-scale association analysis identifies new risk loci for coronary artery disease. Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., & Samani, N. J. (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. Nature genetics, 45(1), 25-33.
  
• Exploring Predisposition and Treatment Response-the Promise of Genomics Pan, S., & Knowles, J. W. (2012). Exploring Predisposition and Treatment Response-the Promise of Genomics. PROGRESS IN CARDIOVASCULAR DISEASES, 55(1), 56-63.
  
• Randomized Trial of Personal Genomics for Preventive Cardiology Design and Challenges Knowles, J. W., Assimes, T. L., Kiernan, M., Pavlovic, A., Goldstein, B. A., & Ioannidis, J. Pa. (2012). Randomized Trial of Personal Genomics for Preventive Cardiology Design and Challenges. CIRCULATION-CARDIOVASCULAR GENETICS, 5(3), 368-376.
  
• The Evolution and Refinement of Traditional Risk Factors for Cardiovascular Disease deGoma, E. M., Knowles, J. W., Angeli, F., Budoff, M. J., & Rader, D. J. (2012). The Evolution and Refinement of Traditional Risk Factors for Cardiovascular Disease. CARDIOLOGY IN REVIEW, 20(3), 118-129.
  
• Use and overuse of left ventriculography Witteles, R. M., Knowles, J. W., Perez, M., Morris, W. M., Spettell, C. M., & Heidenreich, P. A. (2012). Use and overuse of left ventriculography. AMERICAN HEART JOURNAL, 163(4), 617-?.
  
• Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence Dewey, F. E., Chen, R., Cordero, S. P., Ormond, K. E., Caleshu, C., & Ashley, E. A. (2011). Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence. PLOS GENETICS, 7(9).
  
• OVERUSE OF LEFT VENTRICULOGRAPHY Witteles, R., Knowles, J. W., Perez, M., Morris, W. H., Spettell, C. M., & Heidenreich, P. A. (2011). OVERUSE OF LEFT VENTRICULOGRAPHY. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14), E1289-E1289.
  
• Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease Schunkert, H., Koenig, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., & Samani, N. J. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. NATURE GENETICS, 43(4), 333-U153.
  
• A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium Kraja, A. T., Vaidya, D., Pankow, J. S., Goodarzi, M. O., Assimes, T. L., & Borecki, I. B. (2011). A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium. DIABETES, 60(4), 1329-1339.
  
• Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies Assimes, T. L., Holm, H., Kathiresan, S., Reilly, M. P., Thorleifsson, G., & Quertermous, T. (2010). Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(19), 1552-1563.
  
• Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., & Loos, R. Jf. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. NATURE GENETICS, 42(11), 937-U53.
  
• Hundreds of variants clustered in genomic loci and biological pathways affect human height Allen, H. L., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., & Hirschhorn, J. N. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. NATURE, 467(7317), 832-838.
  
• Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans Ingelsson, E., Langenberg, C., Hivert, M.-F., Prokopenko, I., Lyssenko, V., & Florez, J. C. (2010). Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans. DIABETES, 59(5), 1266-1275.
  
• Genome-wide meta-analyses identify multiple loci associated with smoking behavior Furberg, H., Kim, Y., Dackor, J., Boerwinkle, E., Franceschini, N., & Sullivan, P. F. (2010). Genome-wide meta-analyses identify multiple loci associated with smoking behavior. NATURE GENETICS, 42(5), 441-U134.
  
• Clinical assessment incorporating a personal genome Ashley, E. A., Butte, A. J., Wheeler, M. T., Chen, R., Klein, T. E., & Altman, R. B. (2010). Clinical assessment incorporating a personal genome. LANCET, 375(9725), 1525-1535.
  
• Characterizing the admixed African ancestry of African Americans Zakharia, F., Basu, A., Absher, D., Assimes, T. L., Go, A. S., & Tang, H. (2009). Characterizing the admixed African ancestry of African Americans. GENOME BIOLOGY, 10(12).
  
• Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study Assimes, T. L., Knowles, J. W., Basu, A., Iribarren, C., Southwick, A., & Quertermous, T. (2008). Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. HUMAN MOLECULAR GENETICS, 17(15), 2320-2328.
  
• A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease Assimes, T. L., Knowles, J. W., Priest, J. R., Basu, A., Borchert, A., & Quertermous, T. (2008). A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. ATHEROSCLEROSIS, 198(1), 136-144.
  
• Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease Assimes, T. L., Knowles, J. W., Priest, J. R., Basu, A., Volcik, K. A., & Quertermous, T. (2008). Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. HUMAN GENETICS, 123(4), 399-408.
  
• Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLRI) with CAD Knowles, J. W., Assimes, T. L., Boerwinkle, E., Fortmann, S. P., Go, A., & Quertermous, T. (2008). Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLRI) with CAD. BMC MEDICAL GENETICS, 9.
  
• Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics Wheeler, M. T., Ho, M., Knowles, J. W., Pavlovic, A., & Ashley, E. A. (2008). Pharmacogenetics of Heart Failure: Evidence, Opportunities, and Challenges for Cardiovascular Pharmacogenomics. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 1(1), 25-36.
  
• Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction Knowles, J. W., Wang, H., Itakura, H., Southwick, A., Myers, R. M., & Hlatky, M. A. (2007). Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction. AMERICAN HEART JOURNAL, 154(6), 1052-1058.
  
• Genetic susceptibility to peripheral arterial disease: A dark corner in vascular biology Knowles, J. W., Assimes, T. L., Li, J., Quertermous, T., & Cooke, J. P. (2007). Genetic susceptibility to peripheral arterial disease: A dark corner in vascular biology. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 27(10), 2068-2078.
  
• A case of complete heart block reverting to normal sinus rhythm after treatment for cardiac invasive Burkitt's lymphoma Knowles, J. W., Elliott, A. B., & Brody, J. (2007). A case of complete heart block reverting to normal sinus rhythm after treatment for cardiac invasive Burkitt's lymphoma. ANNALS OF HEMATOLOGY, 86(9), 687-690.
  
• Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene Caron, K. Mi., James, L. R., Kim, H. S., Knowles, J., Uhlir, R., & Smithies, O. (2004). Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(9), 3106-3111.
  
• Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A(-/-) apolipoprotein E-/- mice Alexander, M. R., Knowles, J. W., Nishikimi, T., & Maeda, N. (2003). Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A(-/-) apolipoprotein E-/- mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 23(6), 1077-1082.
  
• Common variations in noncoding regions of the human natriuretic peptide receptor A gene have quantitative effects Knowles, J. W., Erickson, L. M., Guy, V. K., Sigel, C. S., Wilder, J. C., & Maeda, N. (2003). Common variations in noncoding regions of the human natriuretic peptide receptor A gene have quantitative effects. HUMAN GENETICS, 112(1), 62-70.
  
• Ventricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibrosis Ellmers, L. J., Knowles, J. W., Kim, H. S., Smithies, O., Maeda, N., & Cameron, V. A. (2002). Ventricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibrosis. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 283(2), H707-H714.
  
• Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice Hodgin, J. B., Knowles, J. W., Kim, H. S., Smithies, O., & Maeda, N. (2002). Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. JOURNAL OF CLINICAL INVESTIGATION, 109(4), 541-548.
  
• Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide Goy, M. F., Oliver, P. M., Purdy, K. E., Knowles, J. W., Fox, J. E., & Maeda, N. (2001). Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide. BIOCHEMICAL JOURNAL, 358, 379-387.
  
• Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice Knowles, J. W., Esposito, G., Mao, L., Hagaman, J. R., Fox, J. E., & Maeda, N. (2001). Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. JOURNAL OF CLINICAL INVESTIGATION, 107(8), 975-984.
  
• Genetic modifiers of atherosclerosis in mice Knowles, J. W., & Maeda, N. (2000). Genetic modifiers of atherosclerosis in mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 20(11), 2336-2345.
  
• Enhanced atherosclerosis and kidney dysfunction in eNOS(-)/(-)Apo(-)/(-) mice are ameliorated by enalapril treatment Knowles, J. W., Reddick, R. L., Jennette, J. C., Shesely, E. G., Smithies, O., & Maeda, N. (2000). Enhanced atherosclerosis and kidney dysfunction in eNOS(-)/(-)Apo(-)/(-) mice are ameliorated by enalapril treatment. JOURNAL OF CLINICAL INVESTIGATION, 105(4), 451-458.
  
• Low salt intake down-regulates the guanylin signaling pathway in rat distal colon Li, Z. P., Knowles, J. W., Goyeau, D., Prabhakar, S., Short, D. B., & Goy, M. F. (1996). Low salt intake down-regulates the guanylin signaling pathway in rat distal colon. GASTROENTEROLOGY, 111(6), 1714-1721.