Our research team Is focused on the discovery of cellular signaling mechanisms that serve as a basis for the development of therapeutic approaches for:

• Alzheimer's Disease
• Huntington's Disease
• Parkinson's Disease
  
• Charcot Marie Tooth  Disease
  

In the lab's Neurotrophin Program, we pioneered the development of small molecule ligands targeted to neurotrophin receptors to promote novel signaling mechanisms. Small molecule-induced modulation of these mechanisms demonstrates therapeutic efficacy in models of:

• Alzheimer's Disease
• Huntington's Disease
• Parkinson's Disease
• Charcot Marie Tooth  Disease
• Stroke
• Multiple Sclerosis
• Spinal Cord injury
• Rett Syndrome
• Down's Syndrome

These novel compounds also stimulate stem cells to promote the formation of new neurons. One of our compounds is currently under development for anticipated human trials.