• Stanford has produced 20 NFL Draft first-round selections
| Player • Position | Year | Pick | Team |
| David DeCastro • OG | 2012 | 24th | Pittsburgh Steelers |
| Andrew Luck • QB | 2012 | 1st | Indianapolis Colts |
| Kwame Harris • OT | 2003 | 26th | San Francisco 49ers |
| Darrien Gordon • CB | 1993 | 22nd | San Diego Chargers |
| Tommy Vardell • FB | 1992 | 9th | Cleveland Browns |
| Bob Whitfield • OT | 1992 | 8th | Atlanta Falcons |
| Brad Muster • FB | 1988 | 23rd | Chicago Bears |
| John Elway • QB | 1983 | 1st | Indianapolis Colts |
| Darrin Nelson • RB | 1982 | 7th | Minnesota Vikings |
| Brian Holloway • OT | 1981 | 19th | New England Patriots |
| Gordon King • OT | 1978 | 10th | New York Giants |
| James Lofton • WR | 1978 | 6th | Green Bay Packers |
| Jeff Siemon • LB | 1972 | 10th | Minnesota Vikings |
| Greg Sampson • DT | 1972 | 6th | Houston Oilers |
| Jim Plunkett • QB | 1971 | 1st | New England Patriots |
| Gene Washington • WR | 1969 | 16th | San Francisco 49ers |
| John Brodie • QB | 1957 | 2nd | San Francisco 49ers |
| Bobby Garrett • QB | 1954 | 1st | Cleveland Browns |
| Frankie Albert • QB | 1942 | 10th | Chicago Bears |
| Pete Kmetovic • RB | 1942 | 3rd | Philadelphia Eagles |
