Edward S. Mocarski

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Edward S. Mocarski, Professor, Microbiology and Immunology, Stanford University School of Medicine, Fairchild D347, Stanford, CA 94305-5124 Tel: (650) 723-6435 FAX: (650) 723-1606
email: mocarski@stanford.edu


Research in my laboratory focusses on one of the human herpesviruses: cytomegalovirus (CMV). This virus is a major medical problem in immunocompromised individuals. The virus is very large, and carries over 200 genes. We have characterized functions involved in viral growth (regulation of gene expression, replication, genome packaging) and pathogenesis (tissue tropism, latency). Importantly, molecular genetic and biochemical approaches have been employed to dissect these functions. Many current efforts have been made possible by our development of genetic methodology to engineer precise mutations into the viral genome. Viral functions regulating tissue tropism and latency are currently a major focus of ongoing work. We have found that CMV resides latent in bone marrow hematopoietic cells and have characterized viral gene functions during latency. Areas of current interest:

1) Genetic and biochemical analysis of functions involved in regulation of viral gene expression, including transcriptional regulatory proteins as well as functions that regulate posttranscriptional events.
2) Analysis of the DNA replication origins employed by CMV to replicate the viral genome during lytic and latent growth and to identify viral functions involved in replication and alteration of the host cell.
3) Signals and mechanisms involved in replication and packaging of herpesvirus genomes.
4) Genetic and biochemical analysis of functions involved in latency and reactivation.

For a list of publications, please go to PubMed and search for "Mocarski ES"

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