Neurology & Neurological Sciences Clinical Trials

Phase III Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy 18.00 Gy and Chemotherapy in Children with Newly Diagnosed Standard Risk Medulloblastoma 
PI: Paul Fisher, MD (NCT00085735)

Efficacy of Carboplatin Administered Concomitantly with Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other than Average Risk Medulloblastoma/PNET Patients  
PI: Paul Fisher, MD (NCT00392327)

Phase II Screening Trial of Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood 
PI: Paul Fisher, MD (NCT01217437)

A Randomized Phase II/III Study of Vorinostat and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab and Local Irradiation Followed by Maintenance Bevacizumab and Temozolomide in Newly Diagnosed High Grade Glioma 
PI: Paul Fisher, MD (NCT01236560)

Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years
PI: Paul Fisher, MD (NCT01096368)

A Phase II Study of Sunitinib in Recurrent, Refractory or Progressive High Grade Glioma and Ependymoma Brain Tumors in Pediatric and Young Adult Patients
 PI: Paul Fisher, MD (NCT01462695)

A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytoma and Optic Pathway Gliomas
 PI: Paul Fisher, MD (NCT01553149)

Phase II Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT
PI: Paul Fisher, MD (NCT01602666)

Risk-Adapted Therapy for Young Children with Embryonal Brain Tumors, High-Grade Glioma, Choroid Plexus Carcinoma Or Ependymoma (SJYC07) 
PI: Paul Fisher, MD (NCT00602667)

Phase I and Pharmacokinetic Study of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma 
PI: Paul Fisher, MD (NCT01089101)

Phase II Clinical Trial Evaluating the Efficacy and Safety of GDC-0449 in Children with Recurrent or Refractory Medulloblastoma 
PI: Paul Fisher, MD (NCT01239316)

Comprehensive Molecular Analysis of Tumor Samples Derived From Patients with Diffuse Brainstem Glioma—A Pilot Study
PI: Paul Fisher, MD (NCT00899834)

A Phase II Placebo-Controlled Trial of Modafinil to Improve Neurocognitive Deficits in Children Treated for a Primary Brain Tumor 
PI: Paul Fisher, MD (NCT01381718)

A Molecular Biology and Phase II Study of Imetelstat (GRN163L) in Children with Recurrent High-Grade Glioma, Ependymoma, Medulloblastoma/Primitive Neuroectodermal Tumor (PNET) and Diffuse Intrinsic Pontine Glioma (DIPG)
PI: Paul Fisher, MD (NCT01836549)

Contact Us

For questions about clinical trials please contact our clinical trials research coordinator Maria Coburn at 650-736-9551 or

For more details on all of our clinical trials visit the SOM Clinical Trial Database or visit