Pharmacokinetic Example (Homework)
1. You have two drugs A and B. A is eliminated by zero order kinetics (rate constant k0) from blood, and B is eliminated by first order kinetics (rate constant k1) from blood. The initial mass of B (micrograms) in blood is 2q and the initial mass of A (micrograms) in blood is q.A. Write the differential equation that governs drug A and its solution. Show the compartmental representation. Use the variables listed above.
B. Write the differential equation that governs drug B and its solution. Show the compartmental representation. Use the variables listed above.
C. What is the time at which 90% of drug A is gone from blood.
D. What is the time at which 90% of drug B is gone from blood.
E. At what time t will the two drugs have the same mass in blood. Show the equations that solve for this.
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