Pediatric Bipolar
Disorders Program



Singh MK, Chang KD, Kelley RG, Saggar M, L Reiss A, Gotlib IH. (2014). Early signs of anomalous neural functional connectivity in healthy offspring of parents with bipolar disorder. Bipolar Disord, doi: 10.1111/bdi.12221

Correll CU, Hauser M, Penzner JB, Auther AM, Kafantaris V, Saito E, Olvet D, Carrión RE, Birmaher B, Chang KD, Delbello MP, Singh MK, Pavuluri M, Cornblatt BA. (2014). Type and duration of subsyndromal symptoms in youth with bipolar I disorder prior to their first manic episode. Bipolar Disord, doi: 10.1111/bdi.12194

Thompson PM and the ENIGMA Consortium. (2014). Large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav, 2014 Jun;8(2):153-82. PMCID: PMC4008818

Kemp DE, Correll CU, Tohen M, Delbello MP, Ganocy SJ, Findling RL, Chang K. (2013). Associations among obesity, acute weight gain, and response to treatment with olanzapine in adolescent schizophrenia. J Child Adolesc Psychopharmacol, 23(8):522-30. PMCID: PMC3804232

Kelley R, Chang KD, Garrett A, Alegría D, Thompson P, Howe M, L Reiss A. (2013).  Deformations of amygdala morphology in familial pediatric bipolar disorder. Bipolar Disord, doi: 10.1111/bdi.12114

Singh MK, Jo B, Adleman NE, Howe M, Bararpour L, Kelley RG, Spielman D, Chang KD. (2013). Prospective neurochemical characterization of child offspring of parents with bipolar disorder. Psychiatry Res, 214(2):153-160. PMCID: PMC3796054

Strawn JR, Adler CM, McNamara RK, Welge JA, Bitter SM, Mills NP, Barzman DH, Cerullo MA, Chang KD, Strakowski SM, Delbello MP. (2013). Antidepressant tolerability in anxious and depressed youth at high risk for bipolar disorder: a prospective naturalistic treatment study. Bipolar Disord, doi: 10.1111/bdi.12113.

Miller S, Chang KD, Ketter T. (July 2013) Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder Comorbidity in Children and Adolescents: Evidence-Based Approach to Diagnosis and Treatment. J Clin Psychiatry. 74(6):628-9.

Singh MK, Kesler SR, Hadi Hosseini SM, Kelley RG, Amatya D, Hamilton JP, Chen MC, Gotlib IH. (April 2013) Anomalous Gray Matter Structural Networks in Major Depressive Disorder. Biol Psychiatry. [Epub ahead of print]

Post RM, Chang K, Frye MA. (February 2013) Paradigm Shift: Preliminary Clinical Categorization of Ultrahigh Risk for Childhood Bipolar Disorder to Facilitate Studies on Prevention. J Clin Psychiatry. 2013 Feb;74(2):167-9.

Miklowitz DJ, Schneck CD, Singh MK, Taylor DO, George EL, Cosgrove VE, Howe ME, Dickinson LM, Garber J, Chang KD. (February 2013) Early Intervention for Sympomatic Youth at Risk for Bipolar Disorder: A Randomized Trial of Famiily-Focused Therapy. J Am Acad Child Adolesc Psychiatry. 52(2):121-31.

Singh MK, Chang KD, Kelley RG, Cui X, Sherdell L, Howe ME, Gotlib IH, Reiss AL (January 2013). Reward Processing in Adolescents with Bipolar Disorder. J Am Acad Child Adolesc Psychiatry. 52(1):68-83.

Singh MK, Chang KD. (2013) Brain Structural Response in Individuals at Familial Risk for Bipolar Disorder: A Tale of Two Outcomes.Biol Psychiatry. 73 (2): 109-10

Whitney J, Howe M, Shoemaker V, Li S, Marie Sanders E, Dijamco C, Acquaye T, Phillips J, Singh M, Chang K. (2013) Socio-emotional processing and functioning of youth at high risk for bipolar diosrder. J Affect Disord. 148 (1): 112-7

Garrett AS, Reiss AL, Howe ME, Kelley RG, Singh MK, Adleman NE, Karchemskiy A, Chang KD. (August 2012) Abnormal Amygdala and Prefrontal Cortex Activation to Facial Expression in Pediatric Bipolar Disorder. J Am Acad Child Adolesc Psychiatry. 51(8): 821-31.

Hafeman DM, Chang KD, Garrett AS, Sanders EM, Phillips ML. (June 2012) Effects of medication on neuroimaging findings in bipolar disorder: an updated review. Bipolar Disorders. 14(4): 375-410.

J Roybal D Md, K Singh M Md, J Roybal V Md, E Cosgrove D Phd, Howe M Lcsw, Kelley R Bs, Goraly NB Md, D Chang K Md. (2012) Biological Evidence for a Neurodevelopmental Model of Pediatric Bipolar Disorder. Isr J Psychiatry Relat Sci. 49(1):28-43.

Strakowski SM, Adler CM, Almeida J, Altshuler LL, Blumberg HP, Chang KD, Delbello MP, Frangou S, McIntosh A, Phillips ML, Sussman JE, Townsend JD. (June 2012) The functional neuroanatomy of bipolar disorder: a consensus model. Bipolar Disorders. 14(4):313-325.

Olsen BT, Ganocy SJ, Bitter SM, Findling RL, Case M, Chang K, Tohen M, Delbello MP. (April 2012) Health-related quality of life as measured by the child health questionnaire in adolescents with bipolar disorder treated with olanzapine. Compr Psychiatry.

Whitney J, Joormann J, Gotlib IH, Kelley RG, Acquaye T, Howe M, Chang KD, Singh MK. (March 2012) Information processing in adolescents with bipolar I disorder. J Child Psychol Psychiatry.

Singh MK, Chang KD. (October 2012) The neural effects of psychotropic medications in children and adolescents. Child Adolesc Psychiatr Clin N Am. 21(4):753-71.

Singh MK, Chang KD, Chen MC, Kelley RG, Garrett A, Mitsunaga MM, Bararpour L, Howe M, Reiss AL, Gotlib IH. (September 2012) Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder. Bipolar Disord. 14(6):585-96.

Karchemskiy A, Garrett A, Howe M, Adleman N, Simeonova DI, Alegria D, Reiss A, Chang K (December 2011) Amygdalar, hippocampal, and thalamic volumes in youth at high risk for development of bipolar disorder. Psychiatry Res. 194(3):319-25.

Liu IY, Howe M, Garrett A, Karchemskiy A, Kelley R, Alegria D, Reiss A, Chang K. (October 2011) Striatal volumes in pediatric bipolar patients with and without comorbid ADHD. Psychiatry Res. 194(1):14-20.

Goldsmith M, Singh M, Chang K. (August 2011) Antidepressants and psychostimulants in pediatric populations: is there an association with mania? Paediatr Drugs. 13(4):225-43.

Roybal DJ, Chang KD, Chen MC, Howe ME, Gotlib IH, Singh MK. (2011 Jun) Characterization and Factors Associated with Sleep Quality in Adolescents with Bipolar I Disorder. Child Psychiatry Hum Dev. 42(6):724-40.

Mitsunaga MM, Garrett A, Howe M, Karchemskiy A, Reiss A, Chang K. (April 2011) Increased subgenual cingulate cortext volume in pediatric bipolar disorder associated with mood stabilizer exposure. J Child Adolesc Psychopharmacol. 149-55.

Singh MK, Spielman D, Libby A, Adams E, Acquaye T, Howe M, Kelley R, Reiss A, Chang KD. (March 2011). Neurochemical deficits in the cerebellar vermis in child offspring of parents with bipolar disorder. Bipolar Disord 2011: 13: 189–197.

Miklowitz DJ, Chang KD, Taylor DO, Georg, EL, Singh MK, Schnec, CD, Dickinson LM, How, ME, Garber J. (2011) Early psychosocial intervention for youth at risk for bipolar I or II disorder: a one-year treatment development trial. Bipolar Disord. 13:67–75.

Singh MK, Spielman D, Libby A, Adams E, Acquaye T, Howe M, Kelley R, Reiss A, Chang KD. (January 2011) Neurochemical deficits in the cerebellar vermis in child offspring of parents with bipolar disorder. Bipolar Disorders. Volume 13, Issue 2, pgs 189-197.

Singh, MK, Spielman, D, Adleman, N, Alegria, D, Howe, M, Reiss, A, Chang, KD (2010) Brain glutamatergic characteristics of pediatric offspring of parents with bipolar disorder. Psychiatry Research: Neuroimaging. 182:165-171.

Singh, MK, Ketter, TA, Chang, KD (2010) Atypical Antipsychotics for Acute Manic and Mixed Episodes in Children and Adolescents with Bipolar Disorder. Drugs. 70(4):433-442.

Chang, KD, Saxena, K, Howe, M, Simeonova, D (2010) Psychotropic Medication Exposure and Age at Onset of Bipolar Disorder in Offspring of Parents with Bipolar Disorder. J Child Adolesc Psychopharmacol. 20(1):25-32.

Singh, MK, Chang, KD, Mazaika, P, Garrett, A, Adleman, N, Kelley, R, Howe, M, Reiss, A. (2010) Neural Correlates of Response Inhibition in Pediatric Bipolar Disorder. J Child Adolesc Psychopharmacol. 20(1):15-24.

DelBello MP, Chang K, Welge JA, Adler CM, Rana M, Howe M, Bryan H, Vogel D, Sampang S, Delgado SV, Sorter M, Strakowski SM. (2009) A double-blind, placebo-controlled pilot study of quetiapine for depressed adolescents with bipolar disorder. Bipolar Disord. 11(5):483-93.

Wagner, KD, Redden, L, Kowatch, RA, Wilens, TE, Segal, S, Chang, KD, Wozniak, P, Vigna, NV, Abi-Saab, W, Saltarelli, M (2009) A double-blind, randomized, placebo-controlled trial of divalproex ER in the treatment of bipolar disorder in children and adolescents. J Am Acad Child Adolesc Psychiatry. 48(5):519-32.

Chang, KD (2009) Challenges in the diagnosis and treatment of pediatric bipolar depression. Dialogues Clin Neurosci. 11(1):73-80.

Simeonova, DI, Jackson, V, Atalla, A, Karchemskiy, A, Howe, M, Adleman, N, Chang, KD (2009) Subcortical volumetric correlates of anxiety in familial pediatric bipolar disorder: A preliminary investigation. Psychiatry Res. 173(2):113-20.

Barnea-Goraly, N, Chang, KD, Karchemskiy, A, Howe, M, Reiss, AL (2009) Limbic and corpus callosum aberrations in adolescents with bipolar disorder: A tract-based spatial statistics analysis. Biol Psychiatry. 66(3):238-44.

Chang, KD, Karchemskiy, A, Kelley, R, Howe, M, Garrett, A, Adleman, N, Reiss, AL (2009) Effect of divalproex on brain morphometry, chemistry, and function in youth at high-risk for bipolar disorder: a pilot study.J Child Adolesc Psychopharmacol 19:51-9.

Singh MK, DelBello MP, Fleck DE, Shear PK, Strakowski SM. (January 2009) Inhibition and attention in adolescents with nonmanic mood disorders and a high risk for developing mania. J Clin Exp Neuropsychol. 31(1):1-7.

Garrett A & Chang, KD (2008). The role of the amygdala in bipolar disorder development. Dev Psychopathol 20(4):1285-96.

Miklowitz, DJ & Chang, KD (2008).  Prevention of bipolar disorder in at-risk children: theoretical assumptions and empirical foundations.  Development and Psychopathology, 20(3), 881-897.

Chang, KD (2008) The bipolar spectrum in children and adolescents: developmental issues, J Clin Psychiatry 69(3):e9.

Chang, KD, Wagner, C, Garrett, A, Howe, M, Reiss, A (2008) A preliminary functional magnetic resonance imaging study of prefrontal-amygdalar changes in adolescents with bipolar depression treated with lamotrigine, Bipolar Disord 10:426-431.

Singh MK, DelBello MP, Strakowski SM. (December 2008) Temperament in child offspring of parents with bipolar disorder. J Child Adolesc Psychopharmacol. 18(6):589-93.

Singh, M & Chang, KD (2007) Impact of Bipolar Disorder on Selected Areas of Pediatric Development: A Research Update, Pediatric Health 1(2):199-216

Madaan, V & Chang, KD (2007) Pharmacotherapeutic strategies for pediatric bipolar disorder, Expert Opinion Pharmacotherapy Aug;8(12):1801-19.

Chang, KD, Howe, M., Gallelli, K., Miklowitz, D. J. (2007) Prevention of pediatric bipolar disorder: Integration of neurobiological and psychosocial processes, Ann New York Acad Sciences1094:235-47.

Baumer, F, Howe, M, Gallelli, K, Chang, KD, (2006) Antidepressant-induced mania in pediatric bipolar disorder: characteristics, risk factors, and the serotonin transporter gene, Biol Psychiatry 60(9):1005-1012.

Chang, KD, Adleman, N, Wagner, C, Barnea-Goraly, N, Garrett, A (2006) Will neuroimaging ever be used to diagnose pediatric bipolar disorder? Dev Psychopathol 18(4): 1133-46.

Chang, KD (2006) Neurodegeneration in pediatric mood disorders: supporting evidence and the case for neuroprotection, Clinical Neuropsychiatry 3(3):184-93.

Chang, KD, Saxena, K, Howe, M (2006) Lamotrigine for the treatment of adolescent bipolar depression, J Amer Acad Child Adolesc Psychiatry 45(3):298-304.

DelBello, MP, Chang, KD (2005) Bipolar disorder in children and adolescents – are we approaching the final frontier? Ed., Bipolar Disorders 7:479–482.

Chang, KD, Karchemskiy, A, Barnea-Goraly, N, Garrett, A, Simeonova, D, Reiss, AL.  (2005), Decreased amygdalar gray matter volume in pediatric familial bipolar disorder, J Am Acad Child Adolesc Psychiatry 44:565-573.

Simeonova, DI, Strong, C, Ketter, T., Chang, KD (2005), Creativity in familial bipolar disorder, J Psychiatry Res 39(6):623-631.

Chang, KD, Adleman, N, Dienes, K, Reiss, AL.  (2004), Anomalous Prefrontal-Subcortical Activation in Familial Pediatric Bipolar Disorder: An fMRI Investigation, Arch Gen Psychiatry 61:781-792.

Chang, KD, Steiner, H, and Ketter, TA.  (2003), Studies of Children and Adolescents at High Risk for Bipolar Disorder, Am J Med Genetics (Semin Med Genet) 123C:26-35.

Chang, KD, Adleman, N, Dienes, K, Reiss, AL, and Ketter, TA.  (2003), Bipolar Offspring: A Window Into Bipolar Disorder Evolution, Biological Psychiatry 53:945-951.

Chang, KD, Adleman, N, Dienes, K, Reiss, AL, and Ketter, TA.  (2003), Decreased N-acetyl aspartate Levels in Pediatric Bipolar Disorder, Biological Psychiatry 53:1059-1065.

Chang, KD, Dienes, K, Blasey, C, Adleman, N, Steiner, H, and Ketter, TA.  (2003), Divalproex in the treatment of bipolar offspring with mood and behavioral disorders, J Clin Psychiatry 64:936-942.

Chang KD, Blasey C, Ketter TA Steiner H. (2001), Family environment of children and adolescents with bipolar parents, Bipolar Disorders 3: 73–78.

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