Structural Molecular Biology

Illuminating Biological Structures at the Atomic and Molecular Levels

Science Highlights Recent Highlights

RNA Protein Complexes

Macromolecular Crystallography


The SMB macromolecular crystallography (MC) program is a major experimental driver for structural biology research, serving the needs of a large number of academic and biotech groups working in this area, particularly in the Western U.S, developing, providing and supporting cutting-edge technologies for a wide-range of user applications.

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Small Angle X-ray Scattering


X-ray scattering from partially ordered arrays of biomolecules typically provides low-resolution (≥ 7-10 Å) structural information under biologically relevant conditions. Studies are relatively fast, require small quantities of material and are well-suited for time resolved measurements. Applications range from conformational change to folding intermediate studies.

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X-ray Spectroscopy & Imaging


Metal ions have key roles in biological structure and function - from being active sites of many enzymes to having roles in signaling pathways and being key elements of cancer chemotherapies and disease-related biological malfunctions. Synchrotron x-ray spectroscopies are a key tool in determining the geometric and electronic structure of metal centers.

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Upcoming Events

SSRL will conduct the 2017 SSRL Summer School on Synchrotron X-Ray Absorption Spectroscopy between June 19 and June 23. The five-day session will provide training in XAS and Imaging theory, experimental design, data acquisition strategies and FEFF based EXAFS data analysis useful to both new and experienced users. Examples will be highlighted in various fields. See event details

New Proposals & Extension Requests - Due Dates

Run Period X-Ray/VUV Macromolecular Crystallography
Quarter 1 June 1 July 1
Quarter 2 September 1 December 1
Quarter 3 December 1 April 1

Beam Time Requests - Due Dates

Run Period X-Ray/VUV Macromolecular Crystallography
Quarter 1 August 22 September 15
Quarter 2 November 23 January 18
Quarter 3 February 22 April 16