Institute for Stem Cell Biology and Regenerative Medicine
Research in the Nakauchi Lab

In the Nakauchi Lab, we are working on uncovering new diseases, elucidating the causes of disease, and developing therapeutic modalities by connecting the knowledge and methodology of basic science including immunology, molecular biology, cell biology, and developmental engineering with clinical medicine. Our ultimate goal is to contribute to establishing new frontiers of stem cell therapy and to make clinical applications of stem cells a reality.
Current work in the Nakauchi Lab includes;
1. Elucidation of heterogeneity and hierarchy in hematopoietic stem cells
2. Rejuvenation of antigen specific T cells for efficient immunotherapy
3. Generation of organs from iPS cells by way of blastocyst complementation

With respect to education, we aim to establish an environment where individuals can make the utmost use of their interests, personalities and abilities in order to foster potential researchers, as a human resource, with a succession of creative studies in the field of bioscience


Recent Publications

1. Okamoto N, Aoto T, Uhara H, Yamazaki S, Akutsu H, Umezawa A, Nakauchi H, Miyachi Y, Saida T, Nishimura EK. A melanocyte-melanoma precursor niche in sweat glands of volar skin. Pigment Cell Melanoma Res. 2014 Jul 26. doi: 10.1111/pcmr.12297. PMID: 25065272

2. Yamamoto R, Morita Y, Nakauchi H. Five-lineage clonal analysis of hematopoietic stem/progenitor cells. Methods Mol Biol. 2014;1185:237-45. doi: 10.1007/978-1-4939-1133-2_16. PMID: 25062633

3. Ishigaki T, Zaike Y, Nojima M, Kobayashi S, Ohno N, Uchimaru K, Tojo A, Nakauchi H, Watanabe N. Quantification of adult T-cell leukemia/lymphoma cells using simple four-color flow cytometry. Clin Chem Lab Med. 2014 Jul 23. doi: 10.1515/cclm-2014-0183. PMID: 25060346

4. Lee JK, Jin HK, Park MH, Kim BR, Lee PH, Nakauchi H, Carter JE, He X, Schuchman EH, Bae JS. Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease. J Exp Med. 2014 Jul 28;211(8):1551-70. doi: 10.1084/jem.20132451. PMID: 25049335

5. Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S. Stepwise Differentiation of Pluripotent Stem Cells into Osteoblasts Using Four Small Molecules under Serum-free and Feeder-free Conditions. Stem Cell Reports. 2014 May 22;2(6):751-60. doi: 10.1016/j.stemcr.2014.04.016. PMID: 24936463


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