Contents
10 March 2020
Vol 13, Issue 622
Vol 13, Issue 622
Research Articles
- Structure-based mechanism of preferential complex formation by apoptosis signal–regulating kinases
SAM domains mediate heterotypic and homotypic interactions between ASK family kinases.
- Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability
Blocking the heat shock chaperone mortalin kills BRAF-mutant and MEK-ERK pathway–driven tumor cells.
Editors' Choice
- Timing matters in combination therapy
Subsequent, not concurrent, treatment with CDK4/6 inhibitors improves the efficacy of chemotherapy.
About The Cover
Online Cover This week features a Research Article that demonstrates that homotypic and heterotypic interactions between kinases of the ASK family are mediated by SAM domains. The image shows structural models for the heterohexamer formed by ASK1 (yellow) and ASK2 (purple). [Image: P. Mace/University of Otago, New Zealand]
