Monther Abu-Remaileh
Assistant Professor of Chemical Engineering and, by courtesy, of Genetics
Bio
The Abu-Remaileh Lab is interested in identifying novel pathways that enable cellular and organismal adaptation to metabolic stress and changes in environmental conditions. We also study how these pathways go awry in human diseases such as cancer, neurodegeneration and metabolic syndrome, in order to engineer new therapeutic modalities.
To address these questions, our lab uses a multidisciplinary approach to study the biochemical functions of the lysosome in vitro and in vivo. Lysosomes are membrane-bound compartments that degrade macromolecules and clear damaged organelles to enable cellular adaptation to various metabolic states. Lysosomal function is critical for organismal homeostasis—mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome.
By developing novel tools and harnessing the power of metabolomics, proteomics and functional genomics, our lab will define 1) how the lysosome communicates with other cellular compartments to fulfill the metabolic demands of the cell under various metabolic states, 2) and how its dysfunction leads to rare and common human diseases. Using insights from our research, we will engineer novel therapies to modulate the pathways that govern human disease.
Academic Appointments
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Assistant Professor, Chemical Engineering
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Assistant Professor (By courtesy), Genetics
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Member, Bio-X
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Faculty Fellow, Stanford ChEM-H
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Member, Wu Tsai Neurosciences Institute
2019-20 Courses
- Biotechnology
CHEMENG 25B, ENGR 25B (Spr) - Graduate Practical Training
CHEMENG 299 (Sum) -
Independent Studies (4)
- Graduate Research Rotation in Chemical Engineering
CHEMENG 399 (Aut, Win, Sum) - Graduate Research in Chemical Engineering
CHEMENG 600 (Aut, Spr, Sum) - Undergraduate Honors Research in Chemical Engineering
CHEMENG 190H (Aut, Win, Spr, Sum) - Undergraduate Research in Chemical Engineering
CHEMENG 190 (Aut, Win, Spr, Sum)
- Graduate Research Rotation in Chemical Engineering