Phenotypic drug susceptibility data on about 2000 HIV-1 isolates. Drug susceptibility to each of the 16 FDA-approved drugs are shown. The first column contains the nucleoside/nucleotide RT inhibitors: 3TC (lamivudine), ABC (abacavir), AZT (zidovudine), DDC (zalcitibine), DDI (didanosine), D4T (stavudine) and TDF (tenofovir). The second column contains the nonnucleoside RT inhibitors: DLV (delavirdine), EFV (efavirenz) and NVP (nevirapine). The third column contains the protease inhibitors: APV (amprenavir), IDV (indinavir), LPV (lopinavir), NFV (nelfinavir), RTV (ritonavir) and SQV (saquinavir). Each point represents the fold decrease in susceptibility of a single virus isolate compared with the susceptibility of a wildtype control isolate (X-axis). Blue points represent results on tests with no known drug-resistance mutations. Red points represent results on tests of isolates with at least one drug-resistance mutation. The maximum number of tests shown (Y-axis) that yield the same result is 40. A large proportion of these results were obtained using one of three well-characterized recombinant virus drug susceptibility assays (–).