Analysis on the critical patch on T0945 (center at SNP 376 H, colored in black). The patch include residues: 245, 308, 312, 313, 314, 315, 374, 375, 376, 377, 378, 379, 380, 381, and 83, which form a tight cluster near 376 H (left). The 15 residues surrounding this SNP are the microenvironments associated with the functional effects of the SNP. However, in the best GDT model (best GDT 220–1, GDT 59.27, PF‐zscore −1.32) these microenvironments are not clustered near 376 H. This is because one of the key loops was predicted away from the functional center. In the best PF ranked model (best PF model, 324–1, GDT 54.07, PF‐zscore −1.55), the corresponding microenvironments form one cluster, with the functional loops predicted in the right position