Publications 2017-03-29T01:45:49+00:00
  1. Bartolome J, Huguenard J, Slotkin TA (1980) Role of ornithine decarboxylase in cardiac growth and hypertrophy. Science. 210:793-4.  
  2. Huguenard JR, Wilson WA (1985) Suppression of repetitive firing of neurons by diphenylbarbituric acid. J Pharmacol Exp Ther. 232:228-31.  
  3. Huguenard JR, Zbicz KL, Lewis DV, Evans GJ, Wilson WA (1985) The ionic mechanism of the slow outward current in Aplysia neurons. J Neurophysiol. 54:449-61.  
  4. Huguenard JR, Wilson WA (1985) Barbiturate-induced alterations in the kinetic parameters of slow outward current in Aplysia giant neurons. J Pharmacol Exp Ther. 234:821-9.  
  5. Lewis DV, Huguenard JR, Anderson WW, Wilson WA (1986) Membrane currents underlying bursting pacemaker activity and spike frequency adaptation in invertebrates. Adv Neurol. 44:235-61.  
  6. Huguenard JR, Alger BE (1986) Whole-cell voltage-clamp study of the fading of GABA-activated currents in acutely dissociated hippocampal neurons. J Neurophysiol. 56:1-18.  
  7. Huguenard JR, Hamill OP, Prince DA (1988) Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component. J Neurophysiol. 59:778-95.  
  8. Shen JM, Huguenard JR, Kriegstein AR (1988) Development of GABA responsiveness in embryonic turtle cortical neurons. Neurosci Lett. 89:335-41.  
  9. Coulter DA, Huguenard JR, Prince DA (1989) Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons. Neurosci Lett. 98:74-8.  
  10. Huguenard JR, Hamill OP, Prince DA (1989) Sodium channels in dendrites of rat cortical pyramidal neurons. Proc Natl Acad Sci U S A. 86:2473-7. PMC286935 
  11. Coulter DA, Huguenard JR, Prince DA (1989) Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol. 25:582-93.  
  12. Coulter DA, Huguenard JR, Prince DA (1989) Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current. J Physiol. 414:587-604. PMC1189159 
  13. Coulter DA, Huguenard JR, Prince DA (1990) Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade. Br J Pharmacol. 100:807-13. PMC1917578 
  14. Coulter DA, Huguenard JR, Prince DA (1990) Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction. Br J Pharmacol. 100:800-6. PMC1917607 
  15. Hamill OP, Huguenard JR, Prince DA (1991) Patch-clamp studies of voltage-gated currents in identified neurons of the rat cerebral cortex. Cereb Cortex. 1:48-61.  
  16. Huguenard JR, Coulter DA, Prince DA (1991) A fast transient potassium current in thalamic relay neurons: kinetics of activation and inactivation. J Neurophysiol. 66:1304-15.  
  17. Huguenard JR, Prince DA (1991) Slow inactivation of a TEA-sensitive K current in acutely isolated rat thalamic relay neurons. J Neurophysiol. 66:1316-28.  
  18. Huguenard JR, Coulter DA, Prince DA (1991) Properties of the low-threshold calcium current in thalamic relay neurons: Recovery from inactivation in relation to the control of repetitive burst generation Exp. Brain Res.: Physiology, Pharmacology and Development of Epileptogenic Phenomena, M.R. Klee (ed.) Frankfurt, Series. 20: 39-43.
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  19. Coulter DA, Huguenard JR, Prince DA (1991) Mechanism of block of thalamic T-type Ca2+ channels by petit mal anticonvulsants Exp. Brain Res.: Physiology, Pharmacology and Development of Epileptogenic Phenomena, M.R. Klee (ed.) Frankfurt, Series. 20: 201-204.  
  20. Huguenard JR, McCormick DA (1992) Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons. J Neurophysiol. 68:1373-83.  
  21. McCormick DA, Huguenard JR (1992) A model of the electrophysiological properties of thalamocortical relay neurons. J Neurophysiol. 68:1384-400.  
  22. Huguenard JR, Prince DA (1992) A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus. J Neurosci. 12:3804-17.  
  23. Huguenard JR, Gutnick MJ, Prince DA (1993) Transient Ca2+ currents in neurons isolated from rat lateral habenula. J Neurophysiol. 70:158-66.  
  24. Chung JM, Huguenard JR, Prince DA (1993) Transient enhancement of low-threshold calcium current in thalamic relay neurons after corticectomy. J Neurophysiol. 70:20-7.  
  25. McCormick DA, Wang Z, Huguenard J (1993) Neurotransmitter control of neocortical neuronal activity and excitability. Cereb Cortex. 3:387-98.  
  26. Huguenard JR, Prince DA (1994) Clonazepam suppresses GABAB-mediated inhibition in thalamic relay neurons through effects in nucleus reticularis. J Neurophysiol. 71:2576-81.  
  27. Huguenard JR, Prince DA (1994) Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects. J Neurosci. 14:5485-502.  
  28. Cox CL, Huguenard JR, Prince DA (1995) Cholecystokinin depolarizes rat thalamic reticular neurons by suppressing a K+ conductance. J Neurophysiol. 74:990-1000.  
  29. Ulrich D, Huguenard JR (1995) Purinergic inhibition of GABA and glutamate release in the thalamus: implications for thalamic network activity. Neuron. 15:909-18.  
  30. Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron. 15:1427-39.  
  31. Destexhe A, Contreras D, Steriade M, Sejnowski TJ, Huguenard JR (1996) In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons. J Neurosci. 16:169-85.  
  32. Huguenard JR (1996) Low-threshold calcium currents in central nervous system neurons. Annu Rev Physiol. 58:329-48.  
  33. Huguenard JR, Chung JM, Prince DA (1996) Excitability changes in thalamic and neocortical neurons after injury. Epilepsy Res Suppl. 12:129-35.
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  34. Cox CL, Huguenard JR, Prince DA (1996) Heterogeneous axonal arborizations of rat thalamic reticular neurons in the ventrobasal nucleus. J Comp Neurol. 366:416-30.  
  35. Ulrich D, Huguenard JR (1996) GABAB receptor-mediated responses in GABAergic projection neurones of rat nucleus reticularis thalami in vitro. J Physiol. 493 ( Pt 3):845-54. PMC1159030
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  36. Kang J, Huguenard JR, Prince DA (1996) Development of BK channels in neocortical pyramidal neurons. J Neurophysiol. 76:188-98.  
  37. Ulrich D, Huguenard JR (1996) Gamma-aminobutyric acid type B receptor-dependent burst-firing in thalamic neurons: a dynamic clamp study. Proc Natl Acad Sci U S A. 93:13245-9. PMC24078 
  38. Kang J, Huguenard JR, Prince DA (1996) Two types of BK channels in immature rat neocortical pyramidal neurons. J Neurophysiol. 76:4194-7.  
  39. Cox CL, Huguenard JR, Prince DA (1997) Peptidergic modulation of intrathalamic circuit activity in vitro: actions of cholecystokinin. J Neurosci. 17:70-82.  
  40. Ulrich D, Huguenard JR (1997) Nucleus-specific chloride homeostasis in rat thalamus. J Neurosci. 17:2348-54.  
  41. Bennett BD, Huguenard JR, Prince DA (1997) Adrenoceptor-mediated elevation of ambient GABA levels activates presynaptic GABA(B) receptors in rat sensorimotor cortex. J Neurophysiol. 78:561-6.  
  42. Cox CL, Huguenard JR, Prince DA (1997) Nucleus reticularis neurons mediate diverse inhibitory effects in thalamus. Proc Natl Acad Sci U S A. 94:8854-9. PMC23165 
  43. Ulrich D, Huguenard JR (1997) GABA(A)-receptor-mediated rebound burst firing and burst shunting in thalamus. J Neurophysiol. 78:1748-51.  
  44. Zhang SJ, Huguenard JR, Prince DA (1997) GABAA receptor-mediated Cl- currents in rat thalamic reticular and relay neurons. J Neurophysiol. 78:2280-6.  
  45. Xiang Z, Huguenard JR, Prince DA (1998) GABAA receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex. J Physiol. 506 ( Pt 3):715-30. PMC2230760 
  46. Bennett BD, Huguenard JR, Prince DA (1998) Adrenergic modulation of GABAA receptor-mediated inhibition in rat sensorimotor cortex. J Neurophysiol. 79:937-46.  
  47. Sohal VS, Cox CL, Huguenard JR (1998) Localization of CCK receptors in thalamic reticular neurons: a modeling study. J Neurophysiol. 79:2820-4.  
  48. Destexhe A, Neubig M, Ulrich D, Huguenard J (1998) Dendritic low-threshold calcium currents in thalamic relay cells. J Neurosci. 18:3574-88.  
  49. Huguenard JR (1998) Anatomical and physiological considerations in thalamic rhythm generation. J Sleep Res. 7 Suppl 1:24-9.  
  50. Xiang Z, Huguenard JR, Prince DA (1998) Cholinergic switching within neocortical inhibitory networks. Science. 281:985-8.  
  51. Sohal VS, Huguenard JR (1998) Long-range connections synchronize rather than spread intrathalamic oscillations: computational modeling and in vitro electrophysiology. J Neurophysiol. 80:1736-51.  
  52. Huguenard JR (1998) Low-voltage-activated (T-type) calcium-channel genes identified. Trends Neurosci. 21:451-2.  
  53. Huntsman MM, Porcello DM, Homanics GE, DeLorey TM, Huguenard JR (1999) Reciprocal inhibitory connections and network synchrony in the mammalian thalamus. Science. 283:541-3.  
  54. Huguenard JR (1999) Neuronal circuitry of thalamocortical epilepsy and mechanisms of antiabsence drug action. Adv Neurol. 79:991-9.  
  55. Sohal VS, Huguenard JR (1999) Long-range connections synchronize rather than spread intrathalamic oscillatory activity: Computational modeling and in vitro electrophysiology Neurocomputing. 26-27:525-531.  
  56. Kang J, Huguenard JR, Prince DA (2000) Voltage-gated potassium channels activated during action potentials in layer V neocortical pyramidal neurons. J Neurophysiol. 83:70-80.  
  57. Huntsman MM, Huguenard JR (2000) Nucleus-specific differences in GABA(A)-receptor-mediated inhibition are enhanced during thalamic development. J Neurophysiol. 83:350-8.
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  58. Sohal VS, Huntsman MM, Huguenard JR (2000) Reciprocal inhibitory connections regulate the spatiotemporal properties of intrathalamic oscillations. J Neurosci. 20:1735-45.  
  59. Sohal VS, Huntsman, MM, Huguenard JR (2000) Reciprocal inhibitory connections produce desynchronizing phase lags during intrathalamic oscillations Neurocomputing. 32: 509-516.  
  60. Huguenard JR (2000) Reliability of axonal propagation: the spike doesn’t stop here. Proc Natl Acad Sci U S A. 97:9349-50. PMC34025 
  61. Huguenard JR (2000) Circuit mechanisms of spike-wave discharge: are there similar underpinnings for centrotemporal spikes? Epilepsia. 41:1076-7.
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  62. Destexhe A, Huguenard JR (2000) Nonlinear thermodynamic models of voltage-dependent currents. J Comput Neurosci. 9:259-70.  
  63. Sun QQ, Huguenard JR, Prince DA (2001) Neuropeptide Y receptors differentially modulate G-protein-activated inwardly rectifying K+ channels and high-voltage-activated Ca2+ channels in rat thalamic neurons. J Physiol. 531:67-79. PMC2278450 
  64. Sun QQ, Akk G, Huguenard JR, Prince DA (2001) Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons. J Physiol. 531:81-94. PMC2278458 
  65. Sohal VS, Huguenard JR (2001) It takes T to tango. Neuron. 31:3-4.  
  66. Jacobsen RB, Ulrich D, Huguenard JR (2001) GABA(B) and NMDA receptors contribute to spindle-like oscillations in rat thalamus in vitro. J Neurophysiol. 86:1365-75.  
  67. Browne SH, Kang J, Akk G, Chiang LW, Schulman H, Huguenard JR, Prince DA (2001) Kinetic and pharmacological properties of GABA(A) receptors in single thalamic neurons and GABA(A) subunit expression. J Neurophysiol. 86:2312-22.  
  68. Kumar SS, Huguenard JR (2001) Properties of excitatory synaptic connections mediated by the corpus callosum in the developing rat neocortex. J Neurophysiol. 86:2973-85.  
  69. Sohal VS, Huguenard JR (2001) Clonazepam suppresses oscillations in rat thalamic slices Neurocomputing. 38-40:907-913.  
  70. Huguenard J (2001) Thalamocortical Circuits and Excitability. Epilepsy Curr. 1:13. PMC320682 
  71. Huguenard JR (2002) Sodium channels: grit, determination, and persistence. Neuron. 33:492-4.  
  72. Porcello DM, Ho CS, Joho RH, Huguenard JR (2002) Resilient RTN fast spiking in Kv3.1 null mice suggests redundancy in the action potential repolarization mechanism. J Neurophysiol. 87:1303-10.  
  73. Xiang Z, Huguenard JR, Prince DA (2002) Synaptic inhibition of pyramidal cells evoked by different interneuronal subtypes in layer v of rat visual cortex. J Neurophysiol. 88:740-50.  F1000 
  74. Kumar SS, Bacci A, Kharazia V, Huguenard JR (2002) A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons. J Neurosci. 22:3005-15.  
  75. Lin SH, Arai AC, España RA, Berridge CW, Leslie FM, Huguenard JR, Vergnes M, Civelli O (2002) Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures. Neuroscience. 114:229-38.  
  76. Huguenard JR (2002) Block of T -Type Ca(2+) Channels Is an Important Action of Succinimide Antiabsence Drugs. Epilepsy Curr. 2:49-52. PMC320968 
  77. Sun QQ, Huguenard JR, Prince DA (2002) Somatostatin inhibits thalamic network oscillations in vitro: actions on the GABAergic neurons of the reticular nucleus. J Neurosci. 22:5374-86.  
  78. Bacci A, Huguenard JR, Prince DA (2002) Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons. Proc Natl Acad Sci U S A. 99:17125-30. PMC139280 
  79. Sohal VS, Huguenard JR (2002) Reciprocal inhibition controls the oscillatory state in thalamic networks Neurocomputing. 44-46:653-659.  
  80. Porcello DM, Huntsman MM, Mihalek RM, Homanics GE, Huguenard JR (2003) Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit. J Neurophysiol. 89:1378-86.  
  81. Porcello DM, Smith SD, Huguenard JR (2003) Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between I(T) and slow intrathalamic rhythms. J Neurophysiol. 89:177-85.  
  82. Bacci A, Huguenard JR, Prince DA (2003) Functional autaptic neurotransmission in fast-spiking interneurons: a novel form of feedback inhibition in the neocortex. J Neurosci. 23:859-66.  F1000 
  83. Bandrowski AE, Huguenard JR, Prince DA (2003) Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol. 89:1308-16. PMC3005275 
  84. Sun QQ, Prince DA, Huguenard JR (2003) Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide activate hyperpolarization-activated cationic current and depolarize thalamocortical neurons in vitro. J Neurosci. 23:2751-8.  
  85. Sohal VS, Keist R, Rudolph U, Huguenard JR (2003) Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations. J Neurosci. 23:3649-57.  
  86. Sohal VS, Huguenard JR (2003) Inhibitory interconnections control burst pattern and emergent network synchrony in reticular thalamus. J Neurosci. 23:8978-88.  
  87. Sun QQ, Baraban SC, Prince DA, Huguenard JR (2003) Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus. J Neurosci. 23:9639-49.  
  88. Bacci A, Rudolph U, Huguenard JR, Prince DA (2003) Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses. J Neurosci. 23:9664-74.  
  89. Huguenard J (2003) Neurotransmitter Supply and Demand in Epilepsy. Epilepsy Curr. 3:61-63. PMC321172 
  90. Kumar SS, Huguenard JR (2003) Pathway-specific differences in subunit composition of synaptic NMDA receptors on pyramidal neurons in neocortex. J Neurosci. 23:10074-83.  F1000 
  91. Huguenard JR (2004) T-Channel Defects in Patients with Childhood Absence Epilepsy. Epilepsy Curr. 4:7-8. PMC324574 
  92. Bacci A, Huguenard JR, Prince DA (2004) Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids. Nature. 431:312-6.  F1000 
  93. Shin J, Shen F, Huguenard JR (2005) Polyamines modulate AMPA receptor-dependent synaptic responses in immature layer v pyramidal neurons. J Neurophysiol. 93:2634-43.  
  94. Jin X, Huguenard JR, Prince DA (2005) Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex. J Neurophysiol. 93:2117-26.  
  95. Bacci A, Huguenard JR, Prince DA (2005) Modulation of neocortical interneurons: extrinsic influences and exercises in self-control. Trends Neurosci. 28:602-10.  
  96. Sohal VS, Huguenard JR (2005) Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types. Proc Natl Acad Sci U S A. 102:18638-43. PMC1317969 
  97. Bacci A, Huguenard JR (2006) Enhancement of spike-timing precision by autaptic transmission in neocortical inhibitory interneurons. Neuron. 49:119-30.  F1000 
  98. Sun QQ, Huguenard JR, Prince DA (2006) Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons. J Neurosci. 26:1219-30.  
  99. Huntsman MM, Huguenard JR (2006) Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor beta1 subunit. J Physiol. 572:459-75. PMC1779681 
  100. Sohal VS, Pangratz-Fuehrer S, Rudolph U, Huguenard JR (2006) Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons. J Neurosci. 26:4247-55.  
  101. Jin X, Prince DA, Huguenard JR (2006) Enhanced excitatory synaptic connectivity in layer v pyramidal neurons of chronically injured epileptogenic neocortex in rats. J Neurosci. 26:4891-900.  
  102. Li H, Kraus A, Wu J, Huguenard JR, Fisher RS (2006) Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the rat. Neuropharmacology. 51:121-8.  
  103. Halabisky B, Shen F, Huguenard JR, Prince DA (2006) Electrophysiological classification of somatostatin-positive interneurons in mouse sensorimotor cortex. J Neurophysiol. 96:834-45.  
  104. Brill J, Lee M, Zhao S, Fernald RD, Huguenard JR (2006) Chronic valproic acid treatment triggers increased neuropeptide y expression and signaling in rat nucleus reticularis thalami. J Neurosci. 26:6813-22.  
  105. Deleuze C, Huguenard JR (2006) Distinct electrical and chemical connectivity maps in the thalamic reticular nucleus: potential roles in synchronization and sensation. J Neurosci. 26:8633-45.  F1000  SI
  106. Tani H, Bandrowski AE, Parada I, Wynn M, Huguenard JR, Prince DA, Reimer RJ (2007) Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy. Neurobiol Dis. 25:230-8. PMC1952182 
  107. Brill J, Kwakye G, Huguenard JR (2007) NPY signaling through Y1 receptors modulates thalamic oscillations. Peptides. 28:250-6. PMC1945169 
  108. Li H, Huguenard JR, Fisher RS (2007) Gender and age differences in expression of GABAA receptor subunits in rat somatosensory thalamus and cortex in an absence epilepsy model. Neurobiol Dis. 25:623-30. PMC2708099 
  109. Pangratz-Fuehrer S, Rudolph U, Huguenard JR (2007) Giant spontaneous depolarizing potentials in the developing thalamic reticular nucleus. J Neurophysiol. 97:2364-72.  
  110. Staley KJ, Huguenard JR (2006) A thalamic sleep tonic. Epilepsy Curr. 6:164-6. PMC1783475 
  111. Kumar SS, Jin X, Buckmaster PS, Huguenard JR (2007) Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy. J Neurosci. 27:1239-46.  
  112. Shin J, Shen F, Huguenard J (2007) PKC and polyamine modulation of GluR2-deficient AMPA receptors in immature neocortical pyramidal neurons of the rat. J Physiol. 581:679-91. PMC2075192 
  113. Huguenard JR, McCormick DA (2007) Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends Neurosci. 30:350-6.  
  114. Schofield CM, Huguenard JR (2007) GABA affinity shapes IPSCs in thalamic nuclei. J Neurosci. 27:7954-62.  
  115. Goddard CA, Knudsen EI, Huguenard JR (2007) Intrinsic excitability of cholinergic neurons in the rat parabigeminal nucleus. J Neurophysiol. 98:3486-93.  
  116. Dulla C, Tani H, Okumoto S, Frommer WB, Reimer RJ, Huguenard JR (2008) Imaging of glutamate in brain slices using FRET sensors. J Neurosci Methods. 168:306-19. PMC2267481 
  117. Sun QQ, Huguenard JR, Prince DA (2005) Reorganization of barrel circuits leads to thalamically-evoked cortical epileptiform activity. Thalamus Relat Syst. 3:261-273. PMC2184932 
  118. Yue BW, Huguenard JR (2001) The role of H-current in regulating strength and frequency of thalamic network oscillations. Thalamus Relat Syst. 1:95-103. PMC2222919 
  119. Beyer B, Deleuze C, Letts VA, Mahaffey CL, Boumil RM, Lew TA, Huguenard JR, Frankel WN (2008) Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4. Hum Mol Genet. 17:1738-49. PMC2405903 
  120. Winsky-Sommerer R, Knapman A, Fedele DE, Schofield CM, Vyazovskiy VV, Rudolph U, Huguenard JR, Fritschy JM, Tobler I (2008) Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice. Neuroscience. 154:595-605. PMC2587445 
  121. Marinelli S, Pacioni S, Bisogno T, Di Marzo V, Prince DA, Huguenard JR, Bacci A (2008) The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons. J Neurosci. 28:13532-41. PMC2615383 
  122. Brill J, Huguenard JR (2008) Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit. J Neurosci. 28:13918-28. PMC2706010 
  123. Schofield CM, Kleiman-Weiner M, Rudolph U, Huguenard JR (2009) A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures. Proc Natl Acad Sci U S A. 106:7630-5. PMC2678654 
  124. Kleiman-Weiner M, Beenhakker MP, Segal WA, Huguenard JR (2009) Synergistic roles of GABAA receptors and SK channels in regulating thalamocortical oscillations. J Neurophysiol. 102:203-13. PMC2712277 
  125. Brill J, Huguenard JR (2009) Robust short-latency perisomatic inhibition onto neocortical pyramidal cells detected by laser-scanning photostimulation. J Neurosci. 29:7413-23. PMC2797487 F1000 
  126. Beenhakker MP, Huguenard JR (2009) Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy? Neuron. 62:612-32. PMC2748990 
  127. Dulla CG, Huguenard JR (2009) Who let the spikes out? Nat Neurosci. 12:959-60. PMC2907263 
  128. Bryant AS, Li B, Beenhakker MP, Huguenard JR (2009) Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle. J Neurophysiol. 102:2880-8. PMC2777838 
  129. Mignot E, Huguenard JR (2009) Resting our cortices by going DOWN to sleep. Neuron. 63:719-21.  
  130. Tani H, Dulla CG, Huguenard JR, Reimer RJ (2010) Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice. J Neurosci. 30:1288-300. PMC2821093 
  131. Brill J, Huguenard JR (2010) Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia. Cereb Cortex. 20:2926-38. PMC3003588 
  132. Paz JT, Christian CA, Parada I, Prince DA, Huguenard JR (2010) Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus. J Neurosci. 30:5465-79. PMC2861582 
  133. Anderson TR, Huguenard JR, Prince DA (2010) Differential effects of Na+-K+ ATPase blockade on cortical layer V neurons. J Physiol. 588:4401-14. PMC3008847 
  134. Jin X, Huguenard JR, Prince DA (2011) Reorganization of inhibitory synaptic circuits in rodent chronically injured epileptogenic neocortex. Cereb Cortex. 21:1094-104. PMC3077430 
  135. Manseau F, Marinelli S, Méndez P, Schwaller B, Prince DA, Huguenard JR, Bacci A (2010) Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons. PLoS Biol. 8:. PMC2946936 
  136. Beenhakker MP, Huguenard JR (2010) Astrocytes as gatekeepers of GABAB receptor function. J Neurosci. 30:15262-76. PMC3056552 
  137. Lee CK, Huguenard JR (2011) Martinotti cells: community organizers. Neuron. 69:1042-5. PMC3068616 
  138. Mao R, Schummers J, Knoblich U, Lacey CJ, Van Wart A, Cobos I, Kim C, Huguenard JR, Rubenstein JL, Sur M (2011) Influence of a Subtype of Inhibitory Interneuron on Stimulus-Specific Responses in Visual Cortex. Cereb Cortex. 22:493-508. PMC3278313 
  139. Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O’Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K (2011) Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature. 477:171-8. PMC4155501 F1000  ESI Highly Cited  SI
  140. Paz JT, Bryant AS, Peng K, Fenno L, Yizhar O, Frankel WN, Deisseroth K, Huguenard JR (2011) A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. Nat Neurosci. 14:1167-73. PMC3308017  SI
  141. Zhang W, Huguenard JR, Buckmaster PS (2012) Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy. J Neurosci. 32:1183-96. PMC3778651 
  142. Goddard CA, Sridharan D, Huguenard JR, Knudsen EI (2012) Gamma oscillations are generated locally in an attention-related midbrain network. Neuron. 73:567-80. PMC3291715 
  143. Paz JT, Huguenard JR (2012) R U OK? The Novel Therapeutic Potential of R Channels in Epilepsy. Epilepsy Curr. 12:75-6. PMC3316366 
  144. Lacey CJ, Bryant A, Brill J, Huguenard JR (2012) Enhanced NMDA receptor-dependent thalamic excitation and network oscillations in stargazer mice. J Neurosci. 32:11067-81. PMC3430525 
  145. Carter ME, Brill J, Bonnavion P, Huguenard JR, Huerta R, de Lecea L (2012) Mechanism for Hypocretin-mediated sleep-to-wake transitions. Proc Natl Acad Sci U S A. 109:E2635-44. PMC3465396 
  146. Dulla CG, Tani H, Brill J, Reimer RJ, Huguenard JR (2012) Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation. Neurobiol Dis. 49C:232-246. PMC3574209 
  147. Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koro (2012) A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 490:187-91. PMC3511845  ESI Highly Cited 
  148. Paz JT, Davidson TJ, Frechette ES, Delord B, Parada I, Peng K, Deisseroth K, Huguenard JR (2013) Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci. 16:64-70. PMC3700812 F1000  ESI Highly Cited 
  149. Ma Y, Huguenard JR (2013) Reemerging role of cable properties in action potential initiation. Proc Natl Acad Sci U S A. 110:3715-6. PMC3593907 
  150. Dewolfe JL, Malow B, Huguenard J, Stickgold R, Bourgeois B, Holmes GL (2013) Sleep and epilepsy: a summary of the 2011 merritt-putnam symposium. Epilepsy Curr. 13:42-9. PMC3577087 
  151. Christian CA, Herbert AG, Holt RL, Peng K, Sherwood KD, Pangratz-Fuehrer S, Rudolph U, Huguenard JR (2013) Endogenous Positive Allosteric Modulation of GABAA Receptors by Diazepam binding inhibitor. Neuron. 78:1063-74. PMC3987987 F1000 
  152. Christian CA, Huguenard JR (2013) Sniffer Patch Laser Uncaging REsponse (SPLURgE): an assay of regional differences in allosteric receptor modulation and neurotransmitter clearance. J Neurophysiol. 110:1722-31. PMC4042414 
  153. Christian CA, Huguenard JR (2013) Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling. Proc Natl Acad Sci U S A. 110:20278-83. PMC3864346 
  154. Kyuyoung CL, Huguenard JR (2014) Modulation of short-term plasticity in the corticothalamic circuit by group III metabotropic glutamate receptors. J Neurosci. 34:675-87. PMC3870944 
  155. Goddard CA, Mysore SP, Bryant AS, Huguenard JR, Knudsen EI (2014) Spatially Reciprocal Inhibition of Inhibition within a Stimulus Selection Network in the Avian Midbrain. PLoS One. 9:e85865. PMC3897538 
  156. Tani H, Dulla CG, Farzampour Z, Taylor-Weiner A, Huguenard JR, Reimer RJ (2014) A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release. Neuron. 81:888-900. PMC4001919 F1000 
  157. Goddard CA, Huguenard J, Knudsen E (2014) Parallel midbrain microcircuits perform independent temporal transformations. J Neurosci. 34:8130-8. PMC4051971 
  158. Mattis J, Brill J, Evans S, Lerner TN, Davidson TJ, Hyun M, Ramakrishnan C, Deisseroth K, Huguenard JR (2014) Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection. J Neurosci. 34:11769-80. PMC4145178 
  159. Leone DP, Heavner WE, Ferenczi EA, Dobreva G, Huguenard JR, Grosschedl R, McConnell SK (2015) Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex. Cereb Cortex. 25:3406-19. PMC4585495 
  160. Makinson CD, Huguenard JR (2015) Attentional flexibility in the thalamus: now we’re getting SOMwhere. Nat Neurosci. 18:2-4. PMC4556356 
  161. Bryant AS, Goddard CA, Huguenard JR, Knudsen EI (2015) Cholinergic control of gamma power in the midbrain spatial attention network. J Neurosci. 35:761-75. PMC4293421 
  162. Farzampour Z, Reimer RJ, Huguenard J (2015) Endozepines. Adv Pharmacol. 72:147-64. PMC4550098 
  163. Farzampour Z, Huguenard J (2015) Seizing upon Mechanisms for Impaired Consciousness. Neuron. 85:453-5. PMC4554486 
  164. Paz JT, Huguenard JR (2015) Optogenetics and epilepsy: past, present and future. Epilepsy Curr. 15:34-8. PMC4320957 
  165. Paz JT, Huguenard JR (2015) Microcircuits and their interactions in epilepsy: is the focus out of focus? Nat Neurosci. 18:351-359. PMC4561622  ESI Highly Cited 
  166. Ma Y, Juntti SA, Hu CK, Huguenard JR, Fernald RD (2015) Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish. Proc Natl Acad Sci U S A. 112:3805-10. PMC4378424 F1000 
  167. Weissberg I, Wood L, Kamintsky L, Vazquez O, Milikovsky DZ, Alexander A, Oppenheim H, Ardizzone C, Becker A, Frigerio F, Vezzani A, Buckwalter MS, Huguenard J, Friedman A, Kaufer D (2015) Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction. Neurobiol Dis. 78:115-125. PMC4426044 
  168. Paşca AM, Sloan SA, Clarke LE, Tian Y, Makinson CD, Huber N, Kim CH, Park JY, O’Rourke NA, Nguyen KD, Smith SJ, Huguenard JR, Geschwind DH, Barres BA, Paşca SP (2015) Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat Methods. 12:671-8. PMC4489980 F1000  ESI Highly Cited 
  169. Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck (2015) Optogenetics: 10 years after ChR2 in neurons-views from the community. Nat Neurosci. 18:1202-1212. PMC4489980 
  170. Pangratz-Fuehrer S, Sieghart W, Rudolph U, Parada I, Huguenard JR (2016) Early Postnatal Switch in GABAAR α Subunits in the Reticular Thalamic Nucleus. J Neurophysiol. 115:1183-1195. PMC4808120 
  171. Hiu T, Farzampour Z, Paz JT, Wang EH, Badgely C, Olson A, Micheva KD, Wang G, Lemmens R, Tran KV, Nishiyama Y, Liang X, Hamilton SA, O’Rourke N, Smith SJ, Huguenard JR, Bliss TM, Steinberg GK (2016) Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target. Brain. 139:468-80. PMC4805083 
  172. Ha H, Huguenard J (2016) Criminal Minds: Cav3.2 Channels Are the Culprits, but NMDAR Are the Co-Conspirators. Epilepsy Curr. 16:36-8. PMC4749115 
  173. Deleuze C, Huguenard JR (2016) Two classes of excitatory synaptic responses in rat thalamic reticular neurons. J Neurophysiol. 116:995-1011. PMC5009213 
  174. Brill J, Mattis J, Deisseroth K, Huguenard JR (2016) LSPS/Optogenetics to Improve Synaptic Connectivity Mapping: Unmasking the Role of Basket Cell-Mediated Feedforward Inhibition. eNeuro. 3:pii: ENEURO.0142-15.2016. PMC4976301 
  175. Fogerson PM, Huguenard JR (2016) Catching a wave. Elife. 5:pii: e21236. PMC5059133 
  176. Fogerson PM, Huguenard JR (2016) Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations. Neuron. 92:687-704.  
  177. Sorokin JM, Davidson TJ, Frechette E, Abramian AM, Deisseroth K, Huguenard JR, Paz JT (2017) Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode. Neuron. 93:194-210.  
  178. Makinson CD, Tanaka BS, Sorokin JM, Wong JC, Christian CA, Goldin AL, Escayg A, Huguenard JR (2017) Regulation of Thalamic and Cortical Network Synchrony by Scn8a. Neuron. 93:1165-1179.   SI
  179. Yackle K, Schwarz LA, Kam K, Sorokin JM, Huguenard JR, Feldman JL, Luo L, Krasnow MA (2017) Breathing control center neurons that promote arousal in mice. Science. 355:1411-1415.  F1000 
  180. Birey F, Andersen J, Makinson CD, Islam S, Wei W, Huber N, Fan HC, Metzler KRC, Panagiotakos G, Thom N, O’Rourke NA, Steinmetz LM, Bernstein JA, Hallmayer J, Huguenard JR, Pasca SP (2017) Assembly of functionally integrated human forebrain spheroids Nature. doi:10.1038/nature22047.  
  181. Sorokin JM, Paz JT, Huguenard JR (2017) Absence seizure susceptibility correlates with pre-ictal β oscillations. J Physiol Paris. :.