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An integrated calcium imaging processing toolbox for the analysis of neuronal population dynamics

June 7, 2017

An integrated calcium imaging processing toolbox for the analysis of neuronal population dynamics

Image credit: Romano et al.

06/07/2017

research article

Mechanisms underlying a thalamocortical transformation during active tactile sensation


When mice perform an active object localization task with their whiskers, thalamic neurons and inhibitory fast-spiking (FS) interneurons in L4 encode whisker movement and touch, whereas L4 excitatory neurons respond almost exclusively to touch. To explain these observations, Gutnisky et al. construct a computational model based on measured circuit parameters. 

Image credit: Alexas_Fotos/ pixabay.com

Mechanisms underlying a thalamocortical transformation during active tactile sensation

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Current Issue

Current Issue May 2017

06/08/2017

review

A comprehensive overview and evaluation of circular RNA detection tools

Circular RNA (circRNA) is mainly generated by the splice donor of a downstream exon joining to an upstream splice acceptor, a phenomenon known as backsplicing. Zeng et al. provide an easy-to-use circRNA read simulator that can produce mimicking backsplicing reads supporting circRNAs deposited in CircBase. The authors compare the performance of 11 circRNA detection tools on both simulated and real datasets. 

Image credit: PLOS

A comprehensive overview and evaluation of circular RNA detection tools

06/08/2017

software paper

Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads


Wick et al. present Unicycler, a new tool for assembling bacterial genomes from a combination of short and long reads, which produces assemblies that are accurate, complete and cost-effective. Unicycler builds an initial assembly graph from short reads using the de novo assembler SPAdes and then simplifies the graph using information from short and long reads.

 


Image credit: Wick et al.

Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads

06/02/2017

research article

A motor-unit based model of muscle fatigue

Skeletal muscle fatigue reduces strength during work and play and profoundly impairs motor function in many neuromuscular disorders. Muscle is composed of groupings of fibres called motor units and these have an extensive range of characteristics from weak and fatigue-resistant to strong and highly fatigable. Potvin and Fuglevand create a model which tracks the fatigue of a population of motor units making up a muscle. 

A motor-unit based model of muscle fatigue

Image credit: Potvin, Fuglevand.

06/07/2017

plos science wednesday

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PLOS Biology author Brian Smith discusses his study showing that birds in the tropics have greater genetic variation than those in more temperate habitats.

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Image credit: Tiffany Cher Cuevas/ unsplash.com

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