Publications

• Epidermal Growth Factor Receptor (EGFR) Signaling Requires a Specific Endoplasmic Reticulum Thioredoxin for the Post-translational Control of Receptor Presentation to the Cell Surface
  Dong, A., Wodziak, D., & Lowe, A. W. (2015). Epidermal Growth Factor Receptor (EGFR) Signaling Requires a Specific Endoplasmic Reticulum Thioredoxin for the Post-translational Control of Receptor Presentation to the Cell Surface. JOURNAL OF BIOLOGICAL CHEMISTRY, 290(13), 8016-8027.
• Loss of Anterior Gradient 2 (Agr2) Expression Results in Hyperplasia and Defective Lineage Maturation in the Murine Stomach
  Gupta, A., Wodziak, D., Tun, M., Bouley, D. M., & Lowe, A. W. (2013). Loss of Anterior Gradient 2 (Agr2) Expression Results in Hyperplasia and Defective Lineage Maturation in the Murine Stomach. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(6), 4321-4333.
• Diagnostic accuracy of cyst fluid amphiregulin in pancreatic cysts
  Tun, M. T., Pai, R. K., Kwok, S., Dong, A., Gupta, A., & Park, W. G. (2012). Diagnostic accuracy of cyst fluid amphiregulin in pancreatic cysts. BMC GASTROENTEROLOGY, 12.
• AGR2 Gene Function Requires a Unique Endoplasmic Reticulum Localization Motif Gupta, A., Dong, A., & Lowe, A. W. (2012). AGR2 Gene Function Requires a Unique Endoplasmic Reticulum Localization Motif. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(7), 4773-4782.
  
• The Human Adenocarcinoma-associated Gene, AGR2, Induces Expression of Amphiregulin through Hippo Pathway Co-activator YAP1 Activation Dong, A., Gupta, A., Pai, R. K., Tun, M., & Lowe, A. W. (2011). The Human Adenocarcinoma-associated Gene, AGR2, Induces Expression of Amphiregulin through Hippo Pathway Co-activator YAP1 Activation. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(20), 18301-18310.
  
• Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response Hase, K., Kawano, K., Nochi, T., Pontes, G. S., Fukuda, S., & Ohno, H. (2009). Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. NATURE, 462(7270), 226-U101.
  
• The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation Wang, Z., Hao, Y., & Lowe, A. W. (2008). The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation. CANCER RESEARCH, 68(2), 492-497.
  
• Gene Expression Patterns in Pancreatic Tumors, Cells and Tissues Lowe, A. W., Olsen, M., Hao, Y., Lee, S. P., Lee, K. T., & Brown, P. O. (2007). Gene Expression Patterns in Pancreatic Tumors, Cells and Tissues. PLOS ONE, 2(3).
  
• Detection of Pancreatic Ductal Adenocarcinoma in Mice by Ultrasound Imaging of Thymocyte Differentiation Antigen 1 Foygel, K., Wang, H., Machtaler, S., Lutz, A. M., Chen, R., & Willmann, J. K. (2013). Detection of Pancreatic Ductal Adenocarcinoma in Mice by Ultrasound Imaging of Thymocyte Differentiation Antigen 1. GASTROENTEROLOGY, 145(4), 885-?.
  
• Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine Park, W. G., Wu, M., Bowen, R., Zheng, M., Fitch, W. L., & Peltz, G. (2013). Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine. GASTROINTESTINAL ENDOSCOPY, 78(2), 295-?.
  
• CITED2 is a novel direct effector of peroxisome proliferator-activated receptor gamma in suppressing hepatocellular carcinoma cell growth Cheung, K.-F., Zhao, J., Hao, Y., Li, X., Lowe, A. W., & Yu, J. (2013). CITED2 is a novel direct effector of peroxisome proliferator-activated receptor gamma in suppressing hepatocellular carcinoma cell growth. CANCER, 119(6), 1217-1226.
  
• Immunohistochemical panel for distinguishing esophageal adenocarcinoma from squamous cell carcinoma: a combination of p63, cytokeratin 5/6, MUC5AC, and anterior gradient homolog 2 allows optimal subtyping DiMaio, M. A., Kwok, S., Montgomery, K. D., Lowe, A. W., & Pai, R. K. (2012). Immunohistochemical panel for distinguishing esophageal adenocarcinoma from squamous cell carcinoma: a combination of p63, cytokeratin 5/6, MUC5AC, and anterior gradient homolog 2 allows optimal subtyping. HUMAN PATHOLOGY, 43(11), 1799-1807.
  
• PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells Chen, C., Fang, R., Chou, L.-C., Lowe, A. W., & Sibley, E. (2012). PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 423(1), 183-187.
  
• The pancreatic zymogen granule membrane protein, GP2, binds Escherichia coli type 1 Fimbriae Yu, S., & Lowe, A. W. (2009). The pancreatic zymogen granule membrane protein, GP2, binds Escherichia coli type 1 Fimbriae. BMC GASTROENTEROLOGY, 9.
  
• Painless Jaundice and Bilaterally Enlarged Sub-mandibular Glands in an Elderly Man Park, W. G., Pai, R., Ro, K., & Lowe, A. W. (2009). Painless Jaundice and Bilaterally Enlarged Sub-mandibular Glands in an Elderly Man. DIGESTIVE DISEASES AND SCIENCES, 54(3), 488-490.
  
• Endoscopic evaluation of esophago-gastro-jejunostomy in rat model of Barrett's esophagus Lu, S., Lowe, A. W., Triadafilopoulos, G., Hsiung, P.-L., Hao, Y., & Wang, T. D. (2009). Endoscopic evaluation of esophago-gastro-jejunostomy in rat model of Barrett's esophagus. DISEASES OF THE ESOPHAGUS, 22(4), 323-330.
  
• Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells Terahara, K., Yoshida, M., Igarashi, O., Nochi, T., Pontes, G. S., & Kiyono, H. (2008). Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. JOURNAL OF IMMUNOLOGY, 180(12), 7840-7846.
  
• Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy Hsiung, P.- lin, Hardy, J., Friedland, S., Soetikno, R., Du, C. B., & Wang, T. D. (2008). Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy. NATURE MEDICINE, 14(4), 454-458.
  
• The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without ha-ras co-transfection Einav, S., Sklan, E. H., Moon, H. M., Gehrig, E., Liu, P., & Glenn, J. S. (2008). The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without ha-ras co-transfection. HEPATOLOGY, 47(3), 827-835.
  
• Gene expression profiles in gallbladder cancer: The close genetic similarity seen for early and advanced gallbladder cancers may explain the poor prognosis Kim, J. hyang, Kim, H. N., Lee, K. T., Lee, J. K., Choi, S.-H., & Lowe, A. W. (2008). Gene expression profiles in gallbladder cancer: The close genetic similarity seen for early and advanced gallbladder cancers may explain the poor prognosis. TUMOR BIOLOGY, 29(1), 41-49.
  
• Physiological and molecular analysis of acid loading mechanisms in squamous and columnar-lined esophagus Lao-Sirieix, P., Corovic, A., Jankowski, J., Lowe, A., Triadafilopoulos, G., & Fitzgerald, R. C. (2008). Physiological and molecular analysis of acid loading mechanisms in squamous and columnar-lined esophagus. DISEASES OF THE ESOPHAGUS, 21(6), 529-538.
  
• Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7 Boonstra, J. J., van der Velden, A. W., Beerens, E. Cw., van Marion, R., Morita-Fujimura, Y., & Dinjens, W. Nm. (2007). Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7. CANCER RESEARCH, 67(17), 7996-8001.
  
• Gene expression changes associated with Barrett's esophagus and Barrett's-associated adenocarcinoma cell lines after acid or bile salt exposure Hao, Y., Sood, S., Triadafilopoulos, G., Kim, J. H., Wang, Z., & Lowe, A. W. (2007). Gene expression changes associated with Barrett's esophagus and Barrett's-associated adenocarcinoma cell lines after acid or bile salt exposure. BMC GASTROENTEROLOGY, 7.
  
• Gene expression profiling in lymph node-positive and lymph node-negative pancreatic cancer Kim, H. N., Choi, D. W., Lee, K. T., Lee, J. K., Heo, J. S., & Lowe, A. W. (2007). Gene expression profiling in lymph node-positive and lymph node-negative pancreatic cancer. PANCREAS, 34(3), 325-334.
  
• The pancreatic stellate cell: a star on the rise in pancreatic diseases Omary, M. B., Lugea, A., Lowe, A. W., & Pandol, S. J. (2007). The pancreatic stellate cell: a star on the rise in pancreatic diseases. JOURNAL OF CLINICAL INVESTIGATION, 117(1), 50-59.
  
• Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma Hao, Y., Triadafilopoulos, G., Sahbaie, P., Young, H. S., Omary, M. B., & Lowe, A. W. (2006). Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma. GASTROENTEROLOGY, 131(3), 925-933.
  
• The genome is now accessible to the endoscopist Lowe, A. W. (2006). The genome is now accessible to the endoscopist. GASTROINTESTINAL ENDOSCOPY, 64(1), 27-28.
  
• Absence of the major zymogen granule membrane protein, GP2, does not affect pancreatic morphology or secretion Yu, S., Michie, S. A., & Lowe, A. W. (2004). Absence of the major zymogen granule membrane protein, GP2, does not affect pancreatic morphology or secretion. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(48), 50274-50279.
  
• Effects of GP2 expression on secretion and endocytosis in pancreatic AR4-2J cells Yu, S., Hao, Y., & Lowe, A. W. (2004). Effects of GP2 expression on secretion and endocytosis in pancreatic AR4-2J cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 322(1), 320-325.
  
• Determination of plasma glycoprotein 2 levels in patients with pancreatic disease Hao, Y., Wang, J., Feng, N. G., & Lowe, A. W. (2004). Determination of plasma glycoprotein 2 levels in patients with pancreatic disease. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 128(6), 668-674.
  
• Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays Iacobuzio-Donahue, C. A., Maitra, A., Olsen, M., Lowe, A. W., van Heek, N. T., & Goggins, M. (2003). Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. AMERICAN JOURNAL OF PATHOLOGY, 162(4), 1151-1162.
  
• Hyposmotic stress induces cell growth arrest via proteasome activation and cyclin/cyclin-dependent kinase degradation Tao, G. Z., Rott, L. S., Lowe, A. W., & Omary, M. B. (2002). Hyposmotic stress induces cell growth arrest via proteasome activation and cyclin/cyclin-dependent kinase degradation. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(22), 19295-19303.
  
• Processing of the major pancreatic zymogen granule membrane protein, GP2 Fritz, B. A., Poppel, C. S., Fei, M. W., & Lowe, A. W. (2002). Processing of the major pancreatic zymogen granule membrane protein, GP2. PANCREAS, 24(4), 336-343.
  
• Effects of keratin filament disruption on exocrine pancreas-stimulated secretion and susceptibility to injury Toivola, D. M., Ku, N. O., Ghori, N., Lowe, A. W., Michie, S. A., & Omary, M. B. (2000). Effects of keratin filament disruption on exocrine pancreas-stimulated secretion and susceptibility to injury. EXPERIMENTAL CELL RESEARCH, 255(2), 156-170.
  
• Characterization of an alternatively spliced isoform of rat vesicle associated membrane protein-2 (VAMP-2) Mandic, R., & Lowe, A. W. (1999). Characterization of an alternatively spliced isoform of rat vesicle associated membrane protein-2 (VAMP-2). FEBS LETTERS, 451(2), 209-213.
  
• Tissue-specific alternative RNA splicing of rat vesicle-associated membrane protein-1 (VAMP-1) Mandic, R., Trimble, W. S., & Lowe, A. W. (1997). Tissue-specific alternative RNA splicing of rat vesicle-associated membrane protein-1 (VAMP-1). GENE, 199(1-2), 173-179.
  
• Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas Wong, S. Me., & Lowe, A. W. (1996). Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas. GENE, 171(2), 311-312.
  
• Polarized GP2 secretion in MDCK cells via GPI targeting and apical membrane-restricted proteolysis Fritz, B. A., & Lowe, A. W. (1996). Polarized GP2 secretion in MDCK cells via GPI targeting and apical membrane-restricted proteolysis. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 270(1), G176-G183.
  
• HIERARCHY OF MECHANISMS INVOLVED IN GENERATING NA/K-ATPASE POLARITY IN MDCK EPITHELIAL-CELLS Mays, R. W., Siemers, K. A., Fritz, B. A., Lowe, A. W., VANMEER, G., & NELSON, W. J. (1995). HIERARCHY OF MECHANISMS INVOLVED IN GENERATING NA/K-ATPASE POLARITY IN MDCK EPITHELIAL-CELLS. JOURNAL OF CELL BIOLOGY, 130(5), 1105-1115.
  
• THE LEVEL OF THE ZYMOGEN GRANULE PROTEIN GP2 IS ELEVATED IN A RAT MODEL FOR ACUTE-PANCREATITIS Lowe, A. W., Luthen, R. E., Wong, S. Me., & Grendell, J. H. (1994). THE LEVEL OF THE ZYMOGEN GRANULE PROTEIN GP2 IS ELEVATED IN A RAT MODEL FOR ACUTE-PANCREATITIS. GASTROENTEROLOGY, 107(6), 1819-1827.
  
• APICAL PLASMA-MEMBRANE PROTEINS ARE NOT OBLIGATORILY STORED IN SECRETORY GRANULES IN EXOCRINE CELLS Colomer, V., Rindler, M. J., & Lowe, A. W. (1994). APICAL PLASMA-MEMBRANE PROTEINS ARE NOT OBLIGATORILY STORED IN SECRETORY GRANULES IN EXOCRINE CELLS. JOURNAL OF CELL SCIENCE, 107, 2271-2277.
  
• IDENTIFICATION OF A VESICLE-ASSOCIATED MEMBRANE-PROTEIN (VAMP)-LIKE MEMBRANE-PROTEIN IN ZYMOGEN GRANULES OF THE RAT EXOCRINE PANCREAS Braun, J. Ea., Fritz, B. A., Wong, S. Me., & Lowe, A. W. (1994). IDENTIFICATION OF A VESICLE-ASSOCIATED MEMBRANE-PROTEIN (VAMP)-LIKE MEMBRANE-PROTEIN IN ZYMOGEN GRANULES OF THE RAT EXOCRINE PANCREAS. JOURNAL OF BIOLOGICAL CHEMISTRY, 269(7), 5328-5335.
  
• ANTISENSE OLIGODEOXYNUCLEOTIDES TO THE CYSTIC-FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBIT CAMP-ACTIVATED BUT NOT CALCIUM-ACTIVATED CHLORIDE CURRENTS Wagner, J. A., McDonald, T. V., NGHIEM, P. T., Lowe, A. W., Schulman, H., & Gardner, P. (1992). ANTISENSE OLIGODEOXYNUCLEOTIDES TO THE CYSTIC-FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBIT CAMP-ACTIVATED BUT NOT CALCIUM-ACTIVATED CHLORIDE CURRENTS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 89(15), 6785-6789.