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J Clin Endocrinol Metab. 2006 May;91(5):1896-900. Epub 2006 Feb 28.

Plasma asymmetric dimethylarginine concentrations are elevated in obese insulin-resistant women and fall with weight loss.

Author information

1
Division of Endocrinology, Stanford University School of Medicine, Stanford, California 94305-5103, USA.

Abstract

CONTEXT:

Plasma asymmetric dimethylarginine (ADMA) concentrations are higher in apparently healthy, insulin-resistant (IR) individuals and decrease in response to thiazolidenedione treatment.

OBJECTIVE:

The objective of the study was to determine whether ADMA concentrations would also fall when insulin sensitivity is enhanced with weight loss in obese individuals. DESIGN/SETTING/PATIENTS/INTERVENTION: Twenty obese women classified as IR or insulin sensitive (IS) on the basis of their steady-state plasma glucose (SSPG) concentration during the insulin suppression test underwent 12 wk of dietary weight loss.

OUTCOME MEASURES:

Plasma glucose, insulin, and ADMA were measured at baseline and after weight loss; change in insulin resistance was quantified by repeating the SSPG after the dietary intervention.

RESULTS:

Although weight loss was similar in the two groups, significant improvements in SSPG, glucose, and insulin concentrations were confined to the IR group. Baseline plasma ADMA concentrations (mean +/- sd) were higher in IR subjects (1.69 +/- 0.44 vs. 1.18 +/- 0.45 micromol/liter, P = 0.02) and decreased to 1.20 +/- 0.22 micromol/liter (P < 0.001) with weight loss. In contrast, ADMA levels did not change with a similar extent of weight loss in the IS group.

CONCLUSION:

Plasma ADMA levels are higher in obese, IR women than in equally obese, IS women and decrease in response to weight loss when associated with enhancement of insulin sensitivity.

PMID:
16507636
DOI:
10.1210/jc.2005-1441
[Indexed for MEDLINE]

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