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ACS Chem Neurosci. 2014 Dec 17;5(12):1144-5. doi: 10.1021/cn500216f. Epub 2014 Sep 26.

Optogenetic approaches to study stroke recovery.

Author information

1
Department of Neurosurgery and Stanford Stroke Center, Stanford University School of Medicine , Stanford, California 94305, United States.

Abstract

Treatment for stroke is very limited, and potential new therapies are focusing on promoting brain repair and plasticity, as they offer a longer therapeutic time window than the current U.S. Food and Drug Administration approved drug. Functional recovery can occur after stroke, and strategies such as direct brain stimulations that promote recovery are promising. Here we review how selective stimulation of neurons in the motor cortex using optogenetics enhances plasticity mechanisms and promotes functional recovery after stroke.

KEYWORDS:

Optogenetics; channelrhodopsin; neurotrophin; plasticity; stroke recovery

PMID:
25259689
DOI:
10.1021/cn500216f
[Indexed for MEDLINE]

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