The Canary Center at Stanford is a newly opened world-class facility dedicated to cancer early detection research programs. The mission of the center is to foster research leading to the development of blood tests and molecular imaging approaches to detect and localize early cancers. The center is the first in the world to integrate research on both in vivo andin vitro diagnostics to deliver these tests, by housing state-of-the-art core facilities and collaborative research programs in molecular imaging, proteomics, chemistry, and bioinformatics. These initiatives have extensive links to the Cancer Center at Stanford, forming a direct pipeline for the translation of early cancer detection research into clinical trials and practice. The Center was established through an alliance between the Canary Foundation, founded by Don Listwin, the Department of Radiology, and the School of Medicine. The center is directed by Dr. Sanjiv Sam Gambhir, Virginia and D.K. Ludwig Professor in Cancer Research and Chairman of the Department of Radiology at Stanford University School of Medicine.