Trial Search Results
A Phase 3 Study of Brentuximab Vedotin (SGN-35) in Patients at High Risk of Residual Hodgkin Lymphoma Following Stem Cell Transplant (The AETHERA Trial)
This is a randomized, double-blind, placebo-controlled, multicenter phase 3 trial to evaluate the efficacy and safety of brentuximab vedotin (SGN-35) and best supportive care (BSC) compared to placebo and BSC in treatment of residual Hodgkin lymphoma (HL) following autologous stem cell transplant (ASCT).
Stanford is currently not accepting patients for this trial.
Lead Sponsor:
Seattle Genetics, Inc.
Collaborator: Millennium Pharmaceuticals, Inc.
Stanford Investigator(s):
Intervention(s):
- Drug: brentuximab vedotin
- Drug: placebo
Phase:
Phase 3
Eligibility
Inclusion Criteria:
- Patients with HL who have received ASCT in the previous 30-45 days
- Patients at high risk of residual HL post ASCT
- Histologically-confirmed HL
- ECOG of 0 or 1
- Adequate organ function
Exclusion Criteria:
- Previous treatment with brentuximab vedotin
- Previously received an allogeneic transplant
- Patients who were determined to have a best clinical response of progressive disease
with salvage treatment immediately prior to ASCT
- History of another primary malignancy that has not been in remission for at least 3
years
- Post ASCT or current therapy with other systemic anti-neoplastic or investigational
agents
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Not currently accepting new patients for this trial
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Physician Referrals
650-723-0822
Not Recruiting