Thiopurine pathway (PharmGKB PA2040: http://www.pharmgkb.org/do/serve?objId=PA2040&objCls=Pathway). ABCC4, multidrug resistance-associated protein 4; ABCC5, multidrug resistance-associated protein 5; ADA, adenosine deaminase; ADK, adenosine kinase; AdoHcy, S-adenosylhomocysteine; AdoMet, S-adenosyl-methionine; AHCY, S-adenosylhomocysteine hydrolase; AOX1, aldehyde oxidase 1; GAR, glycinamide ribotide; GART, phosphoribosylglycinamide formyltransferase; GMPS, guanosine monophosphate synthetase; GSTA1, glutathione-S-transferase A1; GSTA2, glutathione-S-transferase A2; GSTM1, glutathione-S-transferase M1; HPRT1, hypoxanthine guanine phosphoribosyltransferase 1; IMPDH1, inosine monophosphate dehydrogenase type 1; ITPA, inosine triphosphatase pyrophosphatase; MeMP, methylmercaptopurine; 6-meMPR, 6-methylmercaptopurine riboside; MeTGMP, methyl-thioguanosine monophosphate; MeTIMP, methyl-thioinosine monophosphate; MPR, 6-mercaptopurine riboside; NT5E, nucleotidase, ecto-5-prime; 8-OHTG, 8-hydroxythioguanine; PPAT, phosphoribosyl pyrophosphate amidotransferase; PRA, 5-phosphoribosylamine; PRPP, 5-phospho-D-ribose-1-pyrophosphate; PRPS1, phosphoribosyl pyrophosphate synthetase 1; RAC1, ras-related C3 botulinum toxin substrate 1; SLC28A2, solute carrier family 28, member 2; SLC28A3, solute carrier family 28, member 3; SLC29A1, solute carrier family 29, member 1; SLC29A2, solute carrier family 29, member 2; TdGDP, 6-thio-deoxy-guanosine diphosphate; TdGTP, 6-thio-deoxy-guanosine triphosphate; TGDP, 6-thio-guanosine diphosphate; TGMP, thioguanosine monophosphate; TGTP, 6-thio-guanosine triphosphate; TIMP, thioinosine monophosphate; TITP, thioinosine triphosphate; TPMT, thiopurine S-methyltransferase; TXMP, thioxanthosine monophosphate; XDH, xanthine dehydrogenase.