Surprise! HSC are aberrant in chronic lymphocytic leukemia

Ash A Alizadeh; Ravindra Majeti

doi:10.1016/j.ccr.2011.08.001

Surprise! HSC are aberrant in chronic lymphocytic leukemia

Cancer Cell. 2011 Aug 16;20(2):135-6. doi: 10.1016/j.ccr.2011.08.001.

Authors

Ash A Alizadeh¹, Ravindra Majeti

Affiliation

¹ Institute for Stem Cell Biology and Regenerative Medicine, Cancer Institute, and Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. arasha@stanford.edu

PMID: 21840478
DOI: 10.1016/j.ccr.2011.08.001

Abstract

In this issue of Cancer Cell, Kikushige et al. report the surprising finding that, in human chronic lymphocytic leukemia (CLL), hematopoietic stem cells (HSC) aberrantly generate clonal B cells with CLL-like phenotypes, which implicate HSC in the pathogenesis of this mature lymphoid malignancy and has major implications for CLL therapies.

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