J Ultrasound Med. 2016 Jun;35(6):1353-8. doi: 10.7863/ultra.15.02050. Epub 2016 May 9.

Prenatally Diagnosed Cases of Binder Phenotype Complicated by Respiratory Distress in the Immediate Postnatal Period.

Blumenfeld YJ¹, Davis AS², Hintz SR², Milan K³, Messner AH⁴, Barth RA⁵, Hudgins L⁶, Chueh J³, Homeyer M⁶, Bernstein JA⁷, Enns G⁷, Atwal P⁷, Manning M⁸.

Author information

1: Departments of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Stanford University School of Medicine, Stanford, California USACenter for Fetal and Maternal Health, Lucile Packard Children's Hospital Stanford, Palo Alto, California USA yairb@stanford.edu.
2: Departments of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, California USACenter for Fetal and Maternal Health, Lucile Packard Children's Hospital Stanford, Palo Alto, California USA.
3: Departments of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Stanford University School of Medicine, Stanford, California USACenter for Fetal and Maternal Health, Lucile Packard Children's Hospital Stanford, Palo Alto, California USA.
4: Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California USA.
5: Department of Radiology, Stanford University School of Medicine, Stanford, California USACenter for Fetal and Maternal Health, Lucile Packard Children's Hospital Stanford, Palo Alto, California USA.
6: Department of Pediatrics, Division of Medical Genetics, Stanford University School of Medicine, Stanford, California USACenter for Fetal and Maternal Health, Lucile Packard Children's Hospital Stanford, Palo Alto, California USA.
7: Department of Pediatrics, Division of Medical Genetics, Stanford University School of Medicine, Stanford, California USA.
8: Department of Pediatrics, Division of Medical Genetics, Stanford University School of Medicine, Stanford, California USADepartment of Pathology, Stanford University School of Medicine, Stanford, California USA.

Abstract

Binder phenotype, or maxillonasal dysostosis, is a distinctive pattern of facial development characterized by a short nose with a flat nasal bridge, an acute nasolabial angle, a short columella, a convex upper lip, and class III malocclusion. We report 3 cases of prenatally diagnosed Binder phenotype associated with perinatal respiratory impairment.