The CSBS journal club meets monthly on the second Tuesday of every month at noon.  The theme is big data in cancer, and fellows and faculty are encouraged to submit topics and reading material for discussion.

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October 13, 2015
12:00pm-1:00pm
Location: Lorrey Lokey G1002
Christopher McFarland, CSBS Fellow
Topic: Spatial evolutionary models of tumor progression and IntraTumor Heterogeneity (ITH)
Articles: Sottoriva et al (2015) Nature Genetics and Waclaw et al (2015) Nature

November 10, 2015
12:00pm-1:00pm
Location: Lorrey Lokey G1002
Krystal Straessler, CSBS Fellow
Topic: Using single-cell RNA-seq data to study intratumoral heterogeneity
Articles: Patel et al., (2014) Science, Kim et al., (2015) Nature Communications

December 8, 2015
12:00pm-1:00pm
Location: Lorrey Lokey G1002
Mohammad Shahrokh Esfahani, CSBS Fellow
Topic: Mathematical modeling in cancer
Articles: The mathematics of cancer: integrating quantitative models (Nature Reviews 2015) and Improving Cancer Treatment via Mathematical Modeling: Surmounting the Challenges Is Worth the Effort (Cell 2015)
If time allows: Mathematical modeling of pdgf-driven glioblastoma reveals optimized radiation dosing schedules (Cell 2014)

January 12, 2016
12:00pm-1:00pm
Location: Lorrey Lokey G1002
Ryan Corces-Zimmerman, CSBS Fellow
Topic: Chromatin architecture and cancer
Articles: Insulator dysfunction and oncogene activation in IDH mutant gliomas

February 9, 2016
12:00pm-1:00pm
Location: LKSC 209
Loukia Karacosta, CSBS Fellow
Topic: Adaptive resistance and phenotypic plasticity in cancer
Articles: Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition
Other Relevant Articles: Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

March 8, 2016
12:00pm-1:00pm
Location: LKSC 209
Krystal Straessler, CSBS Fellow
Topic: Phylogenetic Reconstruction of Cancer Evolution
Articles: PhyloWGS: Reconstructing subclonal composition and evolution from whole-genome sequencing of tumors

April 5, 2016 (1st Tuesday of the month)
12:00pm-1:00pm
Location: Lorrey Lokey G1002
Ryan Corces-Zimmerman, CSBS Fellow
Topic: Dynamics of epigenetic regulation at the single-cell level
Article: Dynamics of epigenetic regulation at the single-cell level

May 10, 2016
12:00pm-1:00pm
Location: LKSC 209
Krystal Straessler, CSBS Fellow
Topic: In depth analysis of 560 breast cancer WGS
Article: Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Other Relevant Articles: The topography of mutational processes in breast cancer genomes

June 14, 2016
12:00pm-1:00pm
Location: LKSC 209
Topic and reading material TBD