Edward S. Mocarski
Edward S. Mocarski, Professor, Microbiology and
Immunology, Stanford University School of Medicine, Fairchild D347, Stanford,
CA 94305-5124 Tel: (650) 723-6435 FAX: (650) 723-1606
email: mocarski@stanford.edu
Research in my laboratory focusses on one of the human herpesviruses:
cytomegalovirus (CMV). This virus is a major medical problem in immunocompromised
individuals. The virus is very large, and carries over 200 genes. We have
characterized functions involved in viral growth (regulation of gene expression,
replication, genome packaging) and pathogenesis (tissue tropism, latency).
Importantly, molecular genetic and biochemical approaches have been employed
to dissect these functions. Many current efforts have been made possible
by our development of genetic methodology to engineer precise mutations
into the viral genome. Viral functions regulating tissue tropism and latency
are currently a major focus of ongoing work. We have found that CMV resides
latent in bone marrow hematopoietic cells and have characterized viral
gene functions during latency. Areas of current interest:
1) Genetic and biochemical analysis of functions involved in regulation
of viral gene expression, including transcriptional regulatory proteins
as well as functions that regulate posttranscriptional events.
2) Analysis of the DNA replication origins employed by CMV to replicate
the viral genome during lytic and latent growth and to identify viral functions
involved in replication and alteration of the host cell.
3) Signals and mechanisms involved in replication and packaging of
herpesvirus genomes.
4) Genetic and biochemical analysis of functions involved in latency
and reactivation.
For a list of publications, please go to PubMed
and search for "Mocarski ES"
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