The Stanford Synchrotron Radiation Lightsource (SSRL), a directorate of the SLAC National Accelerator Laboratory, is an Office of Science User Facility operated for the U.S. Department of Energy by Stanford University. SSRL produces extremely bright x-rays used to study our world at the atomic and molecular level. As one of five light sources funded by the U.S. Department of Energy Office of Science, SSRL enables research that benefits every sector of the American economy and leads to major advances in energy production, environmental remediation, nanotechnology, new materials, and medicine. SSRL also provides unique educational experiences and serves as a vital training ground for students in the sciences.
Available Equipment
Users conduct experiments at SSRL's approximately 30 experimental stations, which utilize extremely bright x-rays produced by the SPEAR3 storage ring. SSRL provides access to beam lines, instrumentation, ancillary equipment supported by dedicated staff scientists and technicians.
Selected References
High-Resolution Analysis of Zn(2+) Coordination in the Alkaline Phosphatase Superfamily by EXAFS and X-ray Crystallography. Bobyr E, Lassila JK, Wiersma-Koch HI, Fenn TD, Lee JJ, Nikolic-Hughes I, Hodgson KO, Rees DC, Hedman B, Herschlag DJ. Mol Biol. 2012 Jan 6;415(1):102-17. PubMedID: 22056344.
Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I P13 Kinase Inhibitor for Treating Cancer. Burger MT, Pecchi S, Wagman A, Ni Z-J, Knapp M, Hendrickson T, Atallah G, Pfister K, Zhang Y, Bartulis S, Frazier K, Ng S, Smith A, Verhagen J, Haznedar J, Huh K, Iwanowicz E, Xin X, Menezes D, Merritt H, Lee I, Wiesmann M, Kaugman S, Crawford K, Chin M, Bussiere D, Shoemaker K, Zaror I, Maira S-M and Voliva CF. ACS Med. Chem. Lett. (2011)
Improved Molecular Replacement by Density- and Energy-guided Protein Structure Optimization. DiMaio F, Terwilliger TC, Read RJ, Wlodawer A, Oberdorfer G, Wagner U, Valkov E, Alon A, Fass D, Axelrod HL, Das D, Vorobiev SM, Iwaï H, Pokkuluri PR, Baker D. Nature. 2011 May 26;473(7348):540-3. PubMedID: 21532589.
