Beyond making available state-of-the-art, user-friendly facilities and services, the laboratory enables education, methods development, and new applications development, designed to meet the rapidly evolving needs of researchers.
Description of Services
Typical applications and links to sample preparation guidelines are provided for each type of analysis. Please contact us regarding special projects or samples that fall outside the given categories.
- Pure synthetic and small molecules
- Peptides and proteins
- LC-MS
- Assays & Quantitation
- Support for Drug Discovery
- Proteomics: protein ID, peptide mapping
- Metabolomics
- Data analysis & Custom projects
- Open access LC-MS and GC-MS
Current Instrumentation
- Thermo LTQ-Orbitrap Velos nanoUPLC-MS
- Thermo LTQ XL ion trap HPLC-MS
- Thermo LCQ Deca XP+ ion trap DESI-MS
- Thermo Exactive benchtop Orbitrap UPLC-MS
- Micromass Q-Tof hybrid quadrupole-time of flight LC-MS
- Thermo Vantage triple quadrupole UPLC-MS
- Micromass Quattro Premier triple quadrupole HPLC-MS
- Micromass ZQ single quadrupole HPLC-MS (open access)
- Agilent (HP) 7890/5975 GC-MS (open access)
- Agilent (HP) 7890/5975 GC-MS
- Agilent (HP) 6890/5973 GC-MS
- Advion NanoMate Triversa nano-electrospray robot
- Waters Acquity UPLC, nanoUPLC
- Eksigent NanoLC-2D capillary HPLC
Selected References
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. Science. 2008 Sep 12;321(5895):1493-5. PubMedID: 18787169; PMCID: PMC2741612
Neural Precursor Cell-expressed Developmentally Down-regulated Protein 4-2 (Nedd4-2) Regulation by 14-3-3 Protein Binding at Canonical Serum and Glucocorticoid Kinase 1 (SGK1) Phosphorylation Sites. Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR and Bhalla V. The Journal of Biological Chemistry. October 28, 2011; 286, (43): 37830–37840. PubMedID: 21900244.
Colonic Contribution to Uremic Solutes. Aronov PA, Luo F J-G, Plummer NS, Quan Z, Holmes S, Hostetter TH, and Meyer TW. JASN. September 1, 2011; 22 (9): 1769-1776. PubMedID: 21784895
Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae. Tsvetanova NG, Klass DM, Salzman J, Brown PO. PLoS ONE. Sep 10, 2010; 5(9): e12671. doi:10.1371/journal.pone.0012671 PubMedID: 20844764; PMCID: PMC2937035
