2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Support Documents

You will need Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more.

EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments, Volume 1 (PDF) (2012) (344 pp, 3.8M)
This document comprises the first of two EPA reports (U.S. EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments Volumes 1 and 2 [Reanalysis Volumes 1 and 2]) that, together, will respond to the recommendations and comments on 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) dose-response assessment included in the 2006 NAS report, Health Risks from Dioxin and Related Compounds: Evaluation of the EPA Reassessment. This document, Reanalysis Volume 1, includes (1) a systematic evaluation of the peer-reviewed epidemiologic studies and rodent bioassays relevant to TCDD dose-response analysis; (2) dose-response analyses using a TCDD physiologically based pharmacokinetic model that simulates TCDD blood concentrations following oral intake; and (3) an oral reference dose (RfD) for TCDD.
- Appendices for Toxicological Review of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (PDF) (1521 pp, 13.5M) (Appendices only)
- Supporting Reference: Recommended Toxicity Equivalence Factors (TEFs) for Human Health Risk Assessments of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Dioxin-Like Compounds (December 2010)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) IRIS Assessment Summary (2012)
EPA's Dioxin Website