Dr. Brunger's goal is to understand the molecular mechanism of synaptic neurotransmission. They are interested in the structure, function, and dynamics of key players in the synaptic vesicle fusion machinery. Their lab is also working on the mechanism of action of clostridial neurotoxins that target this machinery. Other projects include protein complexes that are involved in synaptic development and the ATPases of the AAA family that are involved in protein complex disassembly and degradation. A molecular understanding of these complex protein machineries may ultimately lead to new therapeutics to treat human diseases.
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