Bio
I am a physician-scientist who has trained in genome science. My research has focused on mechanisms that coordinate the activities of large number of genes in cell fate control. We made a series of discoveries that introduced the important and pervasive roles of long noncoding RNAs in biological regulation. My group has substantial experience in epigenetics and RNA biology, including invention of new methods for epigenomic profiling, map RNA occupancy on chromatin, and define RNA structures genome-wide. My group pioneered methods to identify key regulators of large-scale transcriptional programs; these methods have been highly fruitful for studies of development, cancer, and aging. The long term goal of my laboratory is to decipher the regulatory information in the human genome for disease diagnosis and therapy.
Clinical Focus
- Cancer > Cutaneous (Dermatologic) Oncology
- Dermatology
- General Dermatology
Academic Appointments
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Professor, Dermatology
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Professor, Genetics
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Member, Bio-X
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Member, Stanford Cancer Institute
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Faculty Fellow, Stanford ChEM-H
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Member, Wu Tsai Neurosciences Institute
Administrative Appointments
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Member, Stanford Diabetes Research Center (2018 - Present)
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Director, NIH Center of Excellence in Genomic Science: Center for Personal Dynamic Regulome (2014 - 2019)
Honors & Awards
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Investigator, Howard Hughes Medical Institute (2018)
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NAS Award in Molecular Biology, National Academy of Science (2018)
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Member, National Academy of Medicine (2017)
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Outstanding Investigator Award, National Cancer Institute (2016)
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Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Institute (2015)
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Judson Daland Prize, American Philosophical Society (2014)
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Montagna Lecture, Society for Investigative Dermatology (2012)
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Salvador E. Luria Lecture, Massachusetts Institute of Technology (2012)
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Alfred Marchionini Research Prize, Alfred Marchionini Foundation (2011)
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CE.R.I.E.S. Award, Chanel Research and Technology (2010)
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Early Career Scientist, Howard Hughes Medical Institute (2009-2015)
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Elected Member, American Society for Clinical Investigation (2009)
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Senior Scholar Award in Aging, Ellison Medical Foundation (2009)
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Vilcek Prize for Creative Promise, Vilcek Foundation (2009)
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New Faculty Award, California Institute for Regenerative Medicine (2008-2013)
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Research Scholar Award, American Cancer Society (2007-2010)
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Scholar Award, Damon Runyon Cancer Research Foundation (2006-2008)
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Clinical Scientist Career Development Award (K08), NIH (2004-2009)
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Physician-Scientist Career Development Award, Dermatology Foundation (2004)
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Young Investigator Award, American Academy of Dermatology (2003)
Boards, Advisory Committees, Professional Organizations
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Editorial Board, Molecular Cell (2014 - Present)
Professional Education
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Internship:Santa Clara Valley Medical Center Radiology Residency (2001) CA
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Fellowship:Stanford University School of Medicine Registrar (2004) CA
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Residency:Stanford University School of Medicine Registrar (2003) CA
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Board Certification: Dermatology, American Board of Dermatology (2004)
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Medical Education:Harvard Medical School (2000) MA
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Ph.D., MIT, Biology (1998)
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A.B., Harvard, Biochemistry (1994)