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Manufacturers have developed “engineered sharps”. These are commonly used items (e.g. scalpels, syringes, needles) that have various mechanical devises to vastly decrease the occurrence of injuries due to sharps. CAL-OSHA requires any laboratory using human or primate blood, blood products, cell lines, tissues or other potentially infectious materials to use needleless systems/and or engineered sharps. If a PI/supervisor decides that a non-compliant sharp is necessary for a certain procedure, the reason must be documented in Plant Biosafety of the Local Exposure Control Plan (ECP).