NHLBI Proteomics Center for Systems Immunology

The Stanford NHLBI Proteomics Center brings together an experienced interdisciplinary group of scientists with significant track records in the areas of PAH and autoimmunity, organized around several Cores and five Projects.

Project 1 (led by Drs. Rabinovitch/Nicolls) is investigating the role of viral triggers and inflammatory cells in PAH pathogenesis by using rodent models and patient samples.

Project 2 (led by Dr. Nolan) is developing Phospho-Flow cytometry and mass spectrometry for the isotope-based analysis of signaling pathways at the single-cell level.

Project 3 (led by Dr. Robinson) is characterizing serum autoantibodies and cytokines to define the autoimmune targets associated with disease initiation and progression, with the ultimate goal of developing "clinically actionable" diagnostics for PAH.

Project 4 (led by Dr. Utz) is evaluating the contribution of cytokines, chemokines, growth factors, and signaling pathways to PAH in animals and patients by using the High-throughput Immunophenotyping using Transcription (HIT) reverse phase lysate microarray, cytokine arrays, and Intel peptide array proteomics platforms.

Project 5 (led by Dr. Kodadek) is developing peptoids as antagonists to perturb cells and as detector molecules to profile lineage-specific cell surface molecules and serum autoantibodies.