Energy regulation: HIF MXIes it up with the C-MYC powerhouse

Patrick D Sutphin; Amato J Giaccia; Denise A Chan

doi:10.1016/j.devcel.2007.05.006

Energy regulation: HIF MXIes it up with the C-MYC powerhouse

Dev Cell. 2007 Jun;12(6):845-6. doi: 10.1016/j.devcel.2007.05.006.

Authors

Patrick D Sutphin¹, Amato J Giaccia, Denise A Chan

Affiliation

¹ Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.

PMID: 17543856
DOI: 10.1016/j.devcel.2007.05.006

Abstract

The phenomenon of aerobic glycolysis observed in cancer cells has remained unexplained. In the May 2007 issue of Cancer Cell, Zhang and colleagues determine that the hypoxia-inducible factor family of transcriptional factors regulate mitochondrial biogenesis through inhibition of C-MYC.

Publication types

Review

MeSH terms

Basic Helix-Loop-Helix Transcription Factors / metabolism*
Energy Metabolism*
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
Mitochondria / metabolism*
Neoplasms / genetics
Neoplasms / metabolism*
Neoplasms / pathology
Oxygen / metabolism
Proto-Oncogene Proteins c-myc / antagonists & inhibitors*
Proto-Oncogene Proteins c-myc / physiology
Transcription, Genetic / physiology
Tumor Suppressor Proteins / metabolism*
Von Hippel-Lindau Tumor Suppressor Protein / metabolism

Substances

Basic Helix-Loop-Helix Transcription Factors
HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit
MXI1 protein, human
Proto-Oncogene Proteins c-myc
Tumor Suppressor Proteins
Von Hippel-Lindau Tumor Suppressor Protein
VHL protein, human
Oxygen