Dumontier Lab

The Dumontier laboratory for biomedical knowledge discovery develops computational methods to better understand how living systems respond to chemical agents. We use semantic technologies to integrate and analyze large biomedical data and enable knowledge-based discoveries in biology, biochemistry and medicine. Our major research interests include i) drug repositioning using large scale animal model data, ii) elucidating the mechanism by which complex phenotypes (e.g. side effects) arise from consumption of pharmaceutical products, iii) determining the extent to which drug metabolic products contribute to toxicity, iv) optimizing novel drug therapeutic regimes so as to minimize undesireable side effects and v) understanding the systemic basis of an altered response due to genetic variation. We develop novel methods to accurately capture, publish, discover and re-use biomedical data, ontologies and services using formal knowledge representation and automated reasoning.