Faculty

The Cyert lab is identifying signaling networks for calcineurin, the conserved Ca²⁺/calmodulin-dependent phosphatase and target of immunosuppressants FK506 and cyclosporin A, in yeast and mammals. Cell biological investigations of target dephosphorylation reveal calcineurin’s many physiological functions. The role of short linear peptide motifs, or SLiMs, in substrate recognition and network evolution, as well as in regulation of calcineurin activity is also being examined.