Calvin Kuo

Publications

• Toward recreating colon cancer in human organoids.
  Salahudeen, A. A., & Kuo, C. J. (2015). Toward recreating colon cancer in human organoids. Nature medicine, 21(3), 215-216.
• Ascl2 reinforces intestinal stem cell identity.
  Yan, K. S., & Kuo, C. J. (2015). Ascl2 reinforces intestinal stem cell identity. Cell stem cell, 16(2), 105-106.
• Identification and specification of the mouse skeletal stem cell.
  Chan, C. Kf., Seo, E. Y., Chen, J. Y., Lo, D., McArdle, A., & Longaker, M. T. (2015). Identification and specification of the mouse skeletal stem cell. Cell, 160(1-2), 285-298.
• Through-skull fluorescence imaging of the brain in a new near-infrared window Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., & Dai, H. (2014). Through-skull fluorescence imaging of the brain in a new near-infrared window. NATURE PHOTONICS, 8(9), 723-730.
  
• Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture Li, X., Nadauld, L., Ootani, A., Corney, D. C., Pai, R. K., & Kuo, C. J. (2014). Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. NATURE MEDICINE, 20(7), 769-777.
  
• Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer. Nadauld, L. D., Garcia, S., Natsoulis, G., Bell, J. M., Miotke, L., & Ji, H. P. (2014). Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer. Genome biology, 15(8), 428.
  
• Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling Lim, X., Tan, S. H., Koh, W. L. C., Chau, R. M. W., Yan, K. S., & Nusse, R. (2013). Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling. SCIENCE, 342(6163), 1226-1230.
  
• A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Wei, K., Piecewicz, S. M., McGinnis, L. M., Taniguchi, C. M., Wiegand, S. J., & Kuo, C. J. (2013). A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nature medicine, 19(10), 1331-1337.
  
• A liver Hif-2 alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition Wei, K., Piecewicz, S. M., McGinnis, L. M., Taniguchi, C. M., Wiegand, S. J., & Kuo, C. J. (2013). A liver Hif-2 alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. NATURE MEDICINE, 19(10), 1331-?.
  
• Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Taniguchi, C. M., Finger, E. C., Krieg, A. J., Wu, C., Diep, A. N., & Giaccia, A. J. (2013). Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Nature medicine, 19(10), 1325-1330.
  
• Restriction of intestinal stem cell expansion and the regenerative response by YAP Barry, E. R., Morikawa, T., Butler, B. L., Shrestha, K., de la Rosa, R., & Camargo, F. D. (2013). Restriction of intestinal stem cell expansion and the regenerative response by YAP. NATURE, 493(7430), 106-?.
  
• beta-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., & Hahn, W. C. (2012). beta-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis. CELL, 151(7), 1457-1473.
  
• The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations Yan, K. S., Chia, L. A., Li, X., Ootani, A., Su, J., & Kuo, C. J. (2012). The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(2), 466-471.
  
• Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124 Kuhnert, F., Mancuso, M. R., Shamloo, A., Wang, H.-T., Choksi, V., & Kuo, C. J. (2010). Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124. SCIENCE, 330(6006), 985-989.
  
• Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Ootani, A., Li, X., Sangiorgi, E., Ho, Q. T., Ueno, H., & Kuo, C. J. (2009). Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nature medicine, 15(6), 701-706.
  
• Developmental and pathological angiogenesis in the central nervous system. Vallon, M., Chang, J., Zhang, H., & Kuo, C. J. (2014). Developmental and pathological angiogenesis in the central nervous system. Cellular and molecular life sciences , 71(18), 3489-3506.
  
• Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids Dimarco, R. L., Su, J., Yan, K. S., Dewi, R., Kuo, C. J., & Heilshorn, S. C. (2014). Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids. INTEGRATIVE BIOLOGY, 6(2), 127-142.
  
• Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing b-Catenin Yucel, G., Van Arnam, J., Means, P. C., Huntzicker, E., Altindag, B., & Oro, A. E. (2014). Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing b-Catenin. STEM CELLS, 32(1), 85-92.
  
• A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells Magness, S. T., Puthoff, B. J., Crissey, M. A., Dunn, J., Henning, S. J., & Wong, M. H. (2013). A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 305(8), G542-G551.
  
• A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells Magness, S. T., Puthoff, B. J., Crissey, M. A., Dunn, J., Henning, S. J., & Wong, M. H. (2013). A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 305(8), G542-G551.
  
• The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO Rankin, E. B., Wu, C., Khatri, R., Wilson, T. Ls., Andersen, R., & Giaccia, A. J. (2012). The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO. CELL, 149(1), 63-74.
  
• PDGF-B exploits stromal EPO McGinnis, L. M., & Kuo, C. J. (2012). PDGF-B exploits stromal EPO. NATURE MEDICINE, 18(1), 22-24.
  
• Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling Shkreli, M., Sarin, K. Y., Pech, M. F., Papeta, N., Chang, W., & Artandi, S. E. (2012). Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. NATURE MEDICINE, 18(1), 111-119.
  
• Endochondral ossification is required for haematopoietic stem-cell niche formation Chan, C. Kf., Chen, C.-C., Luppen, C. A., Kim, J.-B., DeBoer, A. T., & Weissman, I. L. (2009). Endochondral ossification is required for haematopoietic stem-cell niche formation. NATURE, 457(7228), 490-U9.
  
• Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126 Kuhnert, F., Mancuso, M. R., Hampton, J., Stankunas, K., Asano, T., & Kuo, C. J. (2008). Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. DEVELOPMENT, 135(24), 3989-3993.
  
• Soluble receptor-mediated selective inhibition of VEGFR and PDGFR beta signaling during physiologic and tumor angiogenesis Kuhnert, F., Tam, B. Yy., Sennino, B., Gray, J. T., Yuan, J., & Kuo, C. J. (2008). Soluble receptor-mediated selective inhibition of VEGFR and PDGFR beta signaling during physiologic and tumor angiogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(29), 10185-10190.
  
• Recombinant adenovirus as a methodology for exploration of physiologic functions of growth factor pathways Wei, K., Kuhnert, F., & Kuo, C. J. (2008). Recombinant adenovirus as a methodology for exploration of physiologic functions of growth factor pathways. JOURNAL OF MOLECULAR MEDICINE-JMM, 86(2), 161-169.
  
• Augmented Wnt signaling in a mammalian model of accelerated aging Liu, H., Fergusson, M. M., Castilho, R. M., Liu, J., Cao, L., & Finkel, T. (2007). Augmented Wnt signaling in a mammalian model of accelerated aging. SCIENCE, 317(5839), 803-806.
  
• Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., & Rando, T. A. (2007). Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. SCIENCE, 317(5839), 807-810.
  
• VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis Tam, B. Yy., Wei, K., Rudge, J. S., Hoffman, J., Holash, J., & Kuo, C. J. (2006). VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. NATURE MEDICINE, 12(7), 793-800.
  
• Apc tumor suppressor gene is the "zonation-keeper" of mouse liver Benhamouche, S., Decaens, T., Godard, C., Chambrey, R., Rickman, D. S., & Colnot, S. (2006). Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. DEVELOPMENTAL CELL, 10(6), 759-770.
  
• Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1 Kuhnert, F., DAVIS, C. R., Wang, H. T., Chu, P., Lee, M., & Kuo, C. J. (2004). Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(1), 266-271.
  
• Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer Kuo, C. J., Farnebo, F., Yu, E. Y., Christofferson, R., Swearingen, R. A., & Mulligan, R. C. (2001). Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(8), 4605-4610.
  
• RAPAMYCIN SELECTIVELY INHIBITS INTERLEUKIN-2 ACTIVATION OF P70 S6 KINASE Kuo, C. J., Chung, J. K., Fiorentino, D. F., Flanagan, W. M., Blenis, J., & Crabtree, G. R. (1992). RAPAMYCIN SELECTIVELY INHIBITS INTERLEUKIN-2 ACTIVATION OF P70 S6 KINASE. NATURE, 358(6381), 70-73.
  
• A TRANSCRIPTIONAL HIERARCHY INVOLVED IN MAMMALIAN CELL-TYPE SPECIFICATION Kuo, C. J., Conley, P. B., Chen, L., Sladek, F. M., Darnell, J. E., & Crabtree, G. R. (1992). A TRANSCRIPTIONAL HIERARCHY INVOLVED IN MAMMALIAN CELL-TYPE SPECIFICATION. NATURE, 355(6359), 457-461.