The Stanford Center for Cancer Systems Biology (CCSB) is one of twelve National Centers for Systems Biology funded by the National Institute of Health and National Cancer Institute's Integrative Cancer Biology Program. The Center is located at Stanford University School of Medicine and represents a multi-disciplinary collaboration. The Stanford CCSB aims to discover molecular mechanisms underlying cancer progression by studying cancer as a complex biological system that is driven, in part, by impaired differentiation.

Our biological projects are integrated with novel computational techniques, designed to dissect processes and causal factors underlying impaired differentiation as a driver of cancer progression in several hematologic malignancies. These computational approaches are applied to the study of differentiation in AML, Follicular Lymphoma and T-ALL. Our integrative approach will enable us to ascertain differences between these hematologic malignancies, and commonalities, which may generalize to other cancers.

Mission Statement

The overarching goal of the Stanford CCSB is to provide a better understanding of the differentiation and self-renewal properties of cancer that will enable us to identify molecular therapeutic targets and strategies to eradicate this disease, or at least, maintain it in a nonlethal state.

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