Our Pioneering Research

Our Center brings together top-ranked scientists, physician-scientists, clinical caregivers and specialists, as well as world-class research teams with the goals of making long lasting changes in the field of allergy and asthma research and developing a cure for allergies and asthma.

Laboratory Research

Advancing the scientific understanding of immune disorders, asthma and allergies through innovative research. We have discovered new treatments and more accurate diagnostic and predictive tests.

Read about new blood tests

Computational Biology Research

Collaborating to create and leverage a database of research findings from leading, like-minded institutions around the world.

Clinical Trials

Translating research discoveries in immunology into treatments for patients around the world. We aim to provide long-lasting, safe, individualized treatments for patients of all ages. Learn more.

We use our innovative measurement tools and scientific knowledge in immunology and genetics to discover the causes of allergies and asthma and develop strategies to prevent them.

Access to our groundbreaking research findings and tests are available to all sites and patients within our worldwide alliance.

Recent Peer-Reviewed Research Publications

2018 Publications

Chinthrajah RS, Purington N, Andorf S, Rosa JS, Mukai K, Hamilton R, Smith BM, Gupta R, Galli SJ, Desai M, Nadeau KC. Development of a Tool Predicting Severity of Allergic Reaction During Peanut Challenge. Ann Allergy Asthma Immunol. 2018 Apr 27. [Epub ahead of print]
Chinthrajah RS, Purington N, Sampath V, Andorf S, Manohar M, Prunicki M, Zhou X, Tupa D, Nadeau KC. High dimensional immune biomarkers demonstrate differences in phenotypes and endotypes in food allergy and asthma. Ann Allergy Asthma Immunol. 2018 Apr 26. [Epub ahead of print]
Yu M, Mukai K, Tsai M, Galli SJ. Thirdhand smoke component can exacerbate a mouse asthma model via mast cells. J Allergy Clin Immunol. 2018 Apr 17. [Epub ahead of print]
Zhang W, Sindher S, Sampath V, Nadeau KC. Comparison of Sublingual Immunotherapy and Oral Immunotherapy in Peanut Allergy. Allergo J Int. Accepted. April 2018. In press.
Zhang W, Lin C, Sampath V, Nadeau K. Impact of allergen immunotherapy in allergic asthma. Immunotherapy. 2018 Mar 23. [Epub ahead of print]
Sampath V, Sindher SB, Zhang W, Nadeau KC. New Treatment Directions in Food Allergy. Ann Allergy Asthma Immunol. 2018 Mar;120(3):254-262.
Mukai K, Tsai M, Saito H, Galli SJ. Mast cells as sources of cytokines, chemokines, and growth factors. Immunol Rev. 2018 Mar;282(1):121-150.
Sindher SB, Long A, Acharya S, Sampath V, Nadeau KC. The Use of Biomarkers to Predict Aero-Allergen and Food Immunotherapy Responses. Clin Rev Allergy Immunol. 2018 Feb 17. [Epub ahead of print]
Andorf S, Purington N, Block WM, Long AJ, Tupa D, Brittain E, Spergel AR, Desai M, Galli SJ, Nadeau KC, Chinthrajah RS. Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial. Lancet Gastroenterol Hepatol. 2018 Feb;3(2):85-94.
Prunicki M, Stell L, Dinakarpandian D, De Planell-Saguerd M, Lucas RW, Hammond SK, Balmes JR, Zhou X, Paglino T, Sabatti C, Miller RL, Nadeau KC. Exposure to NO2, CO, and PM2.5 Is Linked to Regional DNA Methylation Differences in Asthma. Clin Epigenetics. 2018 Jan 5;10:2.
Dhondalay GK, Rael E, Acharya, S, Zhang W, Sampath V, Galli SJ, Tibshirani, R, Boyd SD, Maecker, H, Nadeau KC, Andorf S. Food allergy and omics. 2018 Jan;141:20-29.
Pellerin L, Jenks JA, Chinthrajah S, Dominguez T, Block W, Zhou X, Noshirvan A, Gregori S, Roncarolo MG, Nadeau KC, Bacchetta R. Peanut-specific Tr1 cells induced in vitro from allergic individuals are functionally impaired. J Allergy Clin Immunol. 2018 Jan;141(1):202-213.e8.
Galli SJ, Gaudenzio N. Human mast cells as antigen-presenting cells: when is this role important in vivo? J Allergy Clin Immunol. 2018 Jan;141(1):92-93.

2017 Publications

Andorf S, Manohar M, Dominguez T, Block W, Tupa D, Kshirsagar RA, Sampath V,Chinthrajah RS, Nadeau KC. Feasibility of sustained response through long-term dosing in food allergy immunotherapy. Allergy Asthma Clin Immunol. 2017 Dec 21;13:52.
Andorf S, Manohar M, Dominguez T, Block W, Tupa D, Kshirsagar RA, Sampath V, Chinthrajah RS, Nadeau KC. Observational long-term follow-up study of rapid food oral immunotherapy with omalizumab. Allergy Asthma Clin Immunol. 2017 Dec 21;13:51.
Tsai CT, Mukai K, Robinson PV, Gray MA, Waschmann MB, Lyu SC, Tsai M, Chinthrajah RS, Nadeau KC, Bertozzi CR, Galli SJ. Isotype-Specific Agglutination-PCR (ISAP): a sensitive and multiplex method for measuring allergen-specific IgE. J Allergy Clin Immunol. 2017 Dec 14. [Epub ahead of print]
Sampson HA, Shreffler WG, Yang WH, Sussman GL, Brown-Whitehorn TF, Nadeau KC, Cheema AS, Leonard SA, Pongracic JA, Sauvage-Delebarre C, Assa'ad AH, de Blay F, Bird JA, Tilles SA, Boralevi F, Bourrier T, Hébert J, Green TD, Gerth van Wijk R, Knulst AC, Kanny G, Schneider LC, Kowalski ML, Dupont C. Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity: A Randomized Clinical Trial. JAMA. 2017 Nov 14;318(18):1798-1809.
Lin C, Lee IT, Sampath V, Dinakar C, DeKruyff RH, Schneider LC, Nadeau KC. Combining anti-IgE with oral immunotherapy. Pediatr Allergy Immunol. 2017 Nov;28(7):619-627.
Elizur A, Bollyky JB, Block WM. Elimination diet and the development of multiple tree-nut allergies. Pediatr Res. 2017 Oct;82(4):671-677
Frischmeyer-Guerrerio PA, Masilamani M, Gu W, Brittain E, Wood R, Kim J, Nadeau K, Jarvinen KM, Grishin A, Lindblad R, Sampson HA. Mechanistic Correlates of Clinical Responses to Omalizumab in the Setting of Oral Immunotherapy for Milk Allergy. J Allergy Clin Immunol. 2017 Oct;140(4):1043-1053.e8.
Andorf S, Borres MP, Block W, Tupa D, Bollyky JB, Sampath V, Elizur A, Lidholm, J, Jones JE, Galli SJ, Chinthrajah RS, Nadeau KC. Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children. J Allergy Clin Immunol Pract. 2017 Sep - Oct;5(5):1325-1334.e4.
Pajno GB, Fernandez-Rivas M, Arasi S, Roberts G, Akdis CA, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, Ebisawa M, Eigenmann P, Knol E, Nadeau KC, Poulsen LK, van Ree R, Santos AF, du Toit G, Dhami S, Nurmatov U, Boloh Y, Makela M, O'Mahony L, Papadopoulos N, Sackesen C, Agache I, Angier E, Halken S, Jutel M, Lau S, Pfaar O, Ryan D, Sturm G, Varga EM, van Wijk RG, Sheikh A, Muraro A; EAACI Allergen Immunotherapy Guidelines Group. EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy. Allergy. 2017 Sep 27. [Epub ahead of print].
Boyd SD, Hoh RA, Nadeau KC, Galli SJ. Immune monitoring for precision medicine in allergy and asthma. Curr Opin Immunol. 2017 Sep 6;48:82-91.
Reber LL, Hernandez JD, Galli SJ. The pathophysiology of anaphylaxis. J Allergy Clin Immunol. 2017 Aug;140(2):335-348.
Nurmatov U, Dhami S, Arasi S, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O'Mahony L, Papadopoulos N, Poulsen LK, Sackesen C, Sampson H, Santos A, van Ree R, Timmermans F, Sheikh A. Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis. Allergy. 2017 Aug;72(8):1133-1147.
Chang HY, Nadeau KC. IL-4Rα Inhibitor for Atopic Disease. Cell. 2017 Jul 13;170(2):222.
Muraro A, Lemanske RF Jr, Castells M, Torres MJ, Khan D, Simon HU, Bindslev-Jensen C, Burks W, Poulsen LK, Sampson HA, Worm M, Nadeau KC. Precision Medicine in Allergic Disease - Food Allergy, Drug Allergy, and Anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. Allergy. 2017 Jul;72(7):1006-1021.
Nygaard UC, Li Z, Palys T, Jackson B, Subbiah M, Malipatlolla M, Sampath V, Maecker H, Karagas MR, Nadeau KC. Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures. PLoS One. 2017 Jun 29;12(6):e0179606.
Park HK, Cheng KC, Tetteh AO, Hildemann LM, Nadeau KC. Effectiveness of Air Purifier on Health Outcomes and Indoor Particles in Homes of Children with Allergic Diseases in Fresno: A Pilot Study. J Asthma. 2017 May;54(4):341-346.
Galli SJ. Mast Cells and KIT as Potential Therapeutic Targets in Severe Asthma. N Engl J Med. 2017 May 18;376(20):1983-1984.
Lee EY, Lin J, Noth EM, Hammond SK, Nadeau KC, Eisen EA, Balmes JR. Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study. J Occup Environ Med. 2017 May;59(5):446-452.
Otani IM, Nadeau KC. Biologic Therapies for Immunoglobulin E-mediated Food allergy and Eosinophilic Esophagitis. Immunol Allergy Clin North Am. 2017 May;37(2):369-396.
Mukai K, Karasuyama H, Kabashima K, Kubo M, Galli SJ. Differences in the Importance of Mast Cells, Basophils, IgE, and IgG versus That of CD4(+) T Cells and ILC2 Cells in Primary and Secondary Immunity to Strongyloides venezuelensis. Infect Immun. 2017 Apr 21;85(5).
Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect. 2017 Apr;125(4):511-526.
Freeland DMH, Manohar M, Andorf S, Hobson BD, Zhang W, Nadeau KC. Oral immunotherapy for food allergy. Semin Immunol. 2017 Apr;30:36-44.
MacGinnitie AJ, Rachid R, Gragg H, Little SV, Lakin P, Cianferoni A, Heimall J, Makhija M, Robison R, Chinthrajah RS, Lee J, Lebovidge J, Dominguez T, Rooney C, Lewis MO, Koss J, Burke-Roberts E, Chin K, Logvinenko T, Pongracic JA, Umetsu DT, Spergel J, Nadeau KC, Schneider LC. Omalizumab facilitates rapid oral desensitization for peanut allergy. J Allergy Clin Immunol. 2017 Mar;139(3):873-881.e8.
Ahuja SK, Manoharan MS, Harper NL, Jimenez F, Hobson BD, Martinez H, Ingale P, Liu YG, Carrillo A, Lou Z, Kellog DL, Ahuja SS, Rather CG, Esch RE, Ramirez DA, Clark RA, Nadeau K, Andrews CP, Jacobs RL, He W. Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge. J Allergy Clin Immunol. 2017 Mar;139(3):844-854.
Mukai K, Gaudenzio N, Gupta S, Vivanco N, Bendall SC, Maecker HT, Chinthrajah RS, Tsai M, Nadeau KC, Galli SJ. Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis. J Allergy Clin Immunol. 2017 Mar;139(3):889-899.e11.
Mukai K, Chinthrajah RS, Nadeau KC, Tsai M, Gaudenzio N, Galli SJ. A new fluorescent-avidin-based method for quantifying basophil activation in whole blood. J Allergy Clin Immunol. 2017 Mar;139(3):889-899.e11.
Balbino B, Sibilano R, Starkl P, Marichal T, Gaudenzio N, Karasuyama H, Bruhns P, Tsai M, Reber LL, Galli SJ. Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis. J Allergy Clin Immunol. 2017 Feb;139(2):584-596.e10.
Zhang YZ, Du WX, Fan Y, Yi J, Lyu SC, Nadeau KC, Thomas AL, McHugh T. Purification and Characterization of a Black Walnut (Juglans nigra) Allergen, Jug n 4. J Agric Food Chem. 2017 Jan 18;65(2):454-462.
Beutier H, Gillis CM, Iannascoli B, Godon O, England P, Sibilano R, Reber LL, Galli SJ, Cragg MS, Van Rooijen N, Mancardi DA, Bruhns P, Jönsson F. IgG subclasses determine pathways of anaphylaxis in mice. J Allergy Clin Immunol. 2017 Jan;139(1):269-280.e7.
Gebe JA, Yadava K, Ruppert SM, Marshall P, Hill P, Falk BA, Sweere JM, Han H, Kaber G, Medina C, Mikecz K, Ziegler SF, Balaji S, Keswani SG, de Jesus Perez VA, Butte MJ, Nadeau K, Altemeier WA, Fanger N, Bollyky PL. Modified High Molecular Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance. Am J Respir Cell Mol Biol. 2017 Jan;56(1):109-120.
Sampath V, Tupa D, Graham MT, Chatila TA, Spergel JM, Nadeau KC. Deciphering the black box of food allergy mechanisms. Ann Allergy Asthma Immunol. 2017 Jan;118(1):21-27.

2016 Publications

Sibilano R, Gaudenzio N, DeGorter MK, Reber LL, Hernandez JD, Starkl PM, Zurek OW, Tsai M, Zahner S, Montgomery SB, Roers A, Kronenberg M, Yu M, Galli SJ. A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice. Nat Commun. 2016 Dec 16;7:13696.
Yu W, Freeland DM, Nadeau KC. Food allergy: immune mechanisms, diagnosis and immunotherapy. Nat Rev Immunol. 2016 Dec;16(12):751-765.
Zhang Y, Du WX, Fan Y, Yi J, Lyu SC, Nadeau KC, McHugh TH. Identification, characterization, and initial epitope mapping of pine nut allergen Pin k 2. Food Research International. 2016 Dec;90:268-274.
Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, Abraham RS, Joshi AY, Boyce TG, Butte MJ, Nadeau KC, Balboni I, Sullivan KE, Akhter J, Adeli M, El-Feky RA, El-Ghoneimy DH, Dbaibo G, Wakim R, Azzari C, Palma P, Cancrini C, Capuder K, Condino-Neto A, Costa-Carvalho BT, Oliveira JB, Roifman C, Buchbinder D, Kumanovics A, Franco JL, Niehues T, Schuetz C, Kuijpers T, Yee C, Chou J, Masaad MJ, Geha R, Uzel G, Gelman R, Holland SM, Recher M, Utz PJ, Browne SK, Notarangelo LD. Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 2016 Nov 1;126(11).
Bunning BJ, DeKruyff RH, Nadeau KC. Epigenetic Changes During Food-Specific Immunotherapy. Curr Allergy Asthma Rep. 2016 Nov;16(12):87.
Yip KH, Kolesnikoff N, Hauschild N, Biggs L, Lopez AF, Galli SJ, Kumar S, Grimbaldeston MA. The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation. Nat Commun. 2016 Oct 27;7:13198
Hussey Freeland DM, Fan-Minogue H, Spergel JM, Chatila TA, Nadeau KC. Advances in food allergy oral immunotherapy: toward tolerance. Curr Opin Immunol. 2016 Oct;42:119-123
Graham MT, Andorf S, Spergel JM, Chatila TA, Nadeau KC. Temporal Regulation by Innate Type 2 Cytokines in Food Allergies. Curr Allergy Asthma Rep. 2016 Oct;16(10):75.
Mukai K, Tsai M, Starkl P, Marichal T, Galli SJ. IgE and mast cells in host defense against parasites and venoms. Semin Immunopathol. 2016 Sep;38(5):581-603.
Rael E. Allergen Immunotherapy . Prim Care. 2016 Sep;43(3):487-94.
Dhami S, Nurmatov U, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O'Mahony L, Papadopoulos N, Poulsen L, Sackesen C, Sampson H, Santos A, van Ree R, Timmermans F, Sheikh A. Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review. Clin Transl Allergy. 2016 Jul 5;6:24.
Ng E, Nadeau KC, Wang SX. Giant magnetoresistive sensor array for sensitive and specific multiplexed food allergen detection. Biosens Bioelectron. 2016 Jun 15;15;80:359-65.
Farzan SF, Li Z, Korrick SA, Spiegelman D, Enelow R, Nadeau K, Baker E, Karagas MR. Infant Infections and Respiratory Symptoms in Relation to in Utero Arsenic Exposure in a U.S. Cohort. Environ Health Perspect. 2016 Jun;124(6):840-7.
Zhang Y, Lee B, Du WX, Lyu SC, Nadeau KC, Grauke LJ, Zhang Y, Wang S, Fan Y, Yi J, McHugh TH. Identification and Characterization of a New Pecan [Carya illinoinensis (Wangenh.) K. Koch] Allergen, Car i 2. J Agric Food Chem. 2016 May 25;64(20):4146-51
Pennington LF, Tarchevskaya S, Brigger D, Sathiyamoorthy K, Graham MT, Nadeau KC, Eggel A, Jardetzky TS. Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange. Nat Commun. 2016 May 19;7:11610.
Galli SJ. Toward precision medicine and health: Opportunities and challenges in allergic diseases. J Allergy Clin Immunol. 2016 May;137(5):1289-300.
Wood RA, Kim JS, Lindblad R, Nadeau K, Henning AK, Dawson P, Plaut M, Sampson HA. A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy. J Allergy Clin Immunol. 2016 Apr;137(4):1103-10.e1-11.
Chinthrajah RS, Hernandez JD, Boyd SD, Galli SJ, Nadeau KC. Molecular and cellular mechanisms of food allergy and food tolerance. J Allergy Clin Immunol. 2016 Apr;137(4):984-97.
Ryan JF, Hovde R, Glanville J, Lyu S-C, Ji X, Gupta S, Tibshirani RJ, Jay DC, Boyd SD, Chinthrajah RS, Davis MM, Galli SJ, Maecker HT, Nadeau KC. Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1286-95.
Bauer RN, Chinthrajah RS, Andorf S, Hobson B, Miller RL, Nadeau KC. T-Cell Immunophenotyping of Second-Hand Smoke-related Asthma. Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S95.
Chang, A, Block W, Bollyky JB, Chinthrajah RS, Nadeau KC, Elizur A. Exploring Correlations Between Cross-Reactive Tree Nuts in Multiple Food Allergic Patients. J Allergy Clin Immunol. 2016 Feb;137(2):AB200.
Singh S, Kshirsagar RA , Dominguez TLR, Tupa D, Block W, Chinthrajah RS, Nadeau KC. Long-Term Follow-up of Oral Immunotherapy for Multiple Food Allergies. J Allergy Clin Immunol, 2016 Feb;137(2):AB132.
Elizur A, Bollyky JB, Block W, Nadeau KC. Different Triggers for the Diagnosis of Individual Food Allergies in Multiple Food Allergic Patients. J Allergy Clin Immunol, 2016 Feb;137(2):AB156.
Prunicki M, Zhou X, de Planell-Saguer M, Miller R, Nadeau KC. Identification of Tr1 Cells and Other CD4+ T Cell Subsets in Humans Using Mass Cytometry: A Tool for Understanding Asthma. J Allergy Clin Immuol, 2016 Feb;137(2):AB410.
Slatkin SC, Tupa D, Nadeau KC, Chinthrajah RS. Fraction of Exhaled Nitric Oxide (FeNO) and Abdominal Pain and/or Vomiting in Reaction to Oral Food Challenge. J Allergy Clin Immunol, 2016 Feb;137(2):AB135.
De Schryver S, Dery A, Clarke AE, Nadeau KC, Harada L, Greenwood C, Weatherall K, Daley D, Asai Y, Bamforth F, Ben-Shoshan M. START: Susceptibility to Food Allergies in a Registry of Twins. J Allergy Clin Immunol, 2016 Feb;137(2):AB152
Zhang Y, Du WX, Fan Y, Nadeau KC, McHugh TH. Prediction and Identification of Korean Pine (Pinus koraiensis) Vicilin As a Food. J Allergy Clin Immunol, 2016 Feb;137(2):AB267.
Noshirvan A, Petroni DH, Tsai M, Galli SJ, Chintrajah RS, Nadeau KC. Trends in Adverse Reactions Requiring Epinephrine in the Build-up Phase of Oral Immunotherapy. J Allergy Clin Immunol, 2016 Feb;137(2):AB131.
Galli SJ. The Mast Cell-IgE Paradox: From Homeostasis to Anaphylaxis. Am J Pathol. 2016 Feb;186(2):212-24.
Ma J, Strub P, Lv N, Xiao L, Camargo CA Jr, Buist AS, Lavori PW, Wilson SR, Nadeau KC, Rosas LG. Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma. Eur Respir J. 2016 Jan;47(1):122-32.
Hoh RA, Joshi SA, Liu Y, Wang C, Roskin KM, Lee JY, Pham T, Looney TJ, Jackson KJ, Dixit VP, King J, Lyu SC, Jenks J, Hamilton RG, Nadeau KC, Boyd SD. Single B-cell deconvolution of peanut-specific antibody responses in allergic patients. J Allergy Clin Immunol. 2016 Jan;137(1):157-67.
Galli SJ, Starkl P, Marichal T, Tsai M. Mast cells and IgE in defense against venoms: Possible "good side" of allergy?Allergol Int. 2016 Jan;65(1):3-15.
Cheng K-C, Zheng D, Tetteh AO, Park H-K, Nadeau KC & Hildemann LM. Personal exposure to airborne particulate matter due to residential dryer lint cleaning. Building and Environment. 2016. 98:145-149.
Cheng K-C, Park H-K, Tetteh AO, Zheng D, Ouellette NT, Nadeau KC & Hildemann LM. Mixing and sink effects of air purifiers on indoor PM2.5 concentrations: A pilot study of eight residential homes in Fresno, California. Aerosol Science and Technology. 2016. 50(8):835-845.

2015 Publications

Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA Jr, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC. Future Research Directions in Asthma: An NHLBI Working Group Report. Am J Respir Crit Care Med. 2015 Dec 1;192(11):1366-72.
Chinthrajah RS, Tupa D, Prince BT, Block WM, Rosa JS, Singh AM, Nadeau K. Diagnosis of Food Allergy. Pediatr Clin North Am. 2015 Dec;62(6):1393-408.
Prince BT, Mandel MJ, Nadeau K, Singh AM. Gut Microbiome and the Development of Food Allergy and Allergic Disease. Pediatr Clin North Am. 2015 Dec;62(6):1479-92.
Geifman N, Bollyky J, Bhattacharya S, Butte AJ. Opening clinical trial data:are the voluntary data-sharing portals enough? BMC Med. 2015 Nov 11;13:280.
Walter JE, Rosen LB, Csomos K, et al. Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 2015 Nov 2;125(11):4135-48.
Bégin P, Schulze J, Baron U, Olek S, Bauer RN, Passerini L, Baccheta R, Nadeau KC. Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region. Clin Transl Allergy. 2015 Oct 20;5:35.
Vercelli D, Galli SJ. Editorial overview: Allergy and hypersensitivity: New developments in allergy and type 2 immunity: never a dull moment. Curr Opin Immunol. 2015 Oct;36:ix-xi.
Roskin KM, Simchoni N, Liu Y, Lee JY, Seo K, Hoh RA, Pham T, Park JH, Furman D, Dekker CL, Davis MM, James JA, Nadeau KC, Cunningham-Rundles C, Boyd SD. IgH sequences in common variable immune deficiency reveal altered B cell development and selection. Sci Transl Med. 2015 Aug 26;7(302):302ra135
Lambrecht BN, Galli SJ. SnapShot: Integrated Type 2 Immune Responses. Immunity. 2015 Aug 18; 43(2):408-408.
Quake C, Nadeau KC. The role of epigenetic mediation and the future of food allergy research. Semin Cell Dev Biol. 2015 Jul;43:125-30.
Sabounchi S, Bollyky J, Nadeau K. Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases. Curr Allergy Asthma Rep. 2015 Jun;15(6):533.
Bégin P, Nadeau KC. Changes in peanut-specific T-cell clonotype with oral immunotherapy. J Allergy Clin Immunol. 2015 Jun;135(6):1636-8.
Reber LL, Sibilano R, Mukai K, Galli SJ. Potential effector and immunoregulatory functions of mast cells in mucosal immunity. Mucosal Immunol. 2015 May; 8(3):444-63.
Mathieu AL, Verronese E, Rice GI, Fouyssac F, Bertrand Y, Picard C, Chansel M, Walter JE, Notarangelo LD, Butte MJ, Nadeau KC, Csomos K, Chen DJ, Chen K, Delgado A, Rigal C, Bardin C, Schuetz C, Moshous D, Reumaux H, Plenat F, Phan A, Zabot MT, Balme B, Viel S, Bienvenu J, Cochat P, van der Burg M, Caux C, Kemp EH, Rouvet I, Malcus C, Méritet JF, Lim A, Crow YJ, Fabien N, Ménétrier-Caux C, De Villartay JP, Walzer T, Belot A. PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity. J Allergy Clin Immunol. 2015 Apr 1; S0091-6749(15)00185-2.
Hong X, Hao K, Ladd-Acosta C, Hansen KD, Tsai HJ, Liu X, Xu X, Thornton TA, Caruso D, Keet CA, Sun Y, Wang G, Luo W, Kumar R, Fuleihan R, Singh AM, Kim JS, Story RE, Gupta RS, Gao P, Chen Z, Walker SO, Bartell TR, Beaty TH, Fallin MD, Schleimer R, Holt PG, Nadeau KC, Wood RA, Pongracic JA, Weeks DE, Wang X. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat Commun. 2015 Feb 24;6:6304.
Bauer RN, Manohar M, Singh AM, Jay DC, Nadeau KC. The future of biologics: Applications for food allergy. J Allergy Clin Immunol. 2015 Feb;135(2):312-323.
Pajno GB, Nadeau KC, Passalacqua G, Caminiti L, Hobson B, Jay DC, Arasi S, Chiera F, Salzano G. The evolution of allergen and non-specific immunotherapy: past achievements, current applications and future outlook. Expert Rev Clin Immunol. 2015 Jan;11(1):141-54.
Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth B, Mann J, Pratt B, Balmes J, Hammond K, Eisen E, Nadeau KC. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clin Exp Allergy. 2015 Jan;45(1):238-48.

2014 Publications

Graham MT, Nadeau KC. Lessons learned from mice and man: mimicking human allergy through mouse models. Clin Immunol. 2014 Nov;155(1):1-16.
Sleiman P, Wang ML, Cianferoni A, Aceves S, Gonsalves N, Nadeau KC, Bredenoord A, Furuta G, Spergel J, and Hakonarson H. GWAS identifies four novel eosinophilic esophagitis loci. Nature Communications. 2014 Nov 19;5:5593. *Participated in enrolling patients, provided technical support and material support.
Arasi S, Klingbeil E, Dominguez T, and Nadeau KC. Two year long term data on Quality of Life in Multiple Food Allergy Oral Immunotherapy. Allergy, Asthma, and Clinical Immunology. 2014 Nov; 10:57
Jay D, Manohar M, and Nadeau KC. Immune Mechanisms of Sublingual Immunotherapy. Current Allergy and Asthma Reports. 2014 Nov;14(11):473.
Lv N, Xiao L, Camargo C, Wilson S, Buist S, Strub P, Nadeau K, and Ma J. Abdominal and General Adiposity and Level of Asthma Control in Adults with Uncontrolled Asthma. Annals of the American Thoracic Society. 2014 Oct;11(8):1218-24. *Participated in acquisition of data, technical support, material support, and analysis and interpretation of data.
Luskin AT, Chipps BE, Rasouliyan L, Miller DP, Haselkorn T, Dorenbaum A. Impact of asthma exacerbations and asthma triggers on asthma-related quality of life in patients with severe or difficult-to-treat asthma. J Allergy Clin Immunol Pract. 2014 Sep-Oct; 2(5):544-52. [Epub 2014 Jul 3]
Rothenberg ME, Wen T, Greenberg A, Alpan O, Enav B, Hirano I, Nadeau KC, Kaiser S, Peters T, Perez A, Jones I, Arm JP, Strieter RM, Sabo R, Gunawardena KA. Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Sep 13. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Alexander ES, Martin LJ, Collins MH, Kottyan LC, Sucharew H, He H, Mukkada VA, Succop PA, Abonia JP, Foote H, Eby MD, Grotjan TM, Greenler AJ, Dellon ES, Demain JG, Furuta GT, Gurian LE, Harley JB, Hopp RJ, Kagalwalla A, Kaul A, Nadeau KC, Noel RJ, Putnam PE, von Tiehl KF, Rothenberg ME. Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Sep 1. *Participated in enrolling patients in the study and acquisition of data.
Sampson H, Aceves S, Bock A, James J, Jones S, Lang D, Nadeau KC, Nowak-Wegrzyn A, Oppenheimer J, Perry T, Randolph C, Sicherer S, Simon R, Vickery B, and Wood R. Food Allergy: A practice parameter update-2014. J. of Allergy and Clinical Immunology. 2014 Aug. E publication. *Participated in design of parameters, material support, and review of data.
Manohar M and Nadeau KC. The Potential of anti-IgE in Food Allergy Therapy. Current Treatment Options in Allergy. 2014 Jun 1;1(2):145-156
Padula AM, Balmes JR, Eisen EA, Mann J, Noth EM, Lurmann FW, Pratt B, Tager IB, Nadeau K, Hammond SK. Ambient polycyclic aromatic hydrocarbons and pulmonary function in children. J Expo Sci Environ Epidemiol. 2014 Jun 18. *Participated in conception and design, enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
McKenzie RB, Berquist WE, Nadeau KC, Louie CY, Chen SF, Sibley RK, Glader BE, Wong WB, Hofmann LV, Esquivel CO, Cox KL. Novel protocol including liver biopsy to identify and treat CD8+ T-cell predominant acute hepatitis and liver failure. Pediatr Transplant. 2014 Jun 14. *Participated in conception and design, enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Begin P, Chinthrajah RS, Nadeau KC. Oral immunotherapy for the treatment of food allergy. Hum Vaccin Immunother. 2014 Jun 5;10(8).
Begin P and Nadeau KC. Epigenetic regulation of asthma and allergic disease. Allergy, Asthma, and Clinical Immunology. 2014 May 28;10 (1):27.
Otani IM, Bégin P, Kearney C, Dominguez TL, Mehrotra A, Bacal LR, Wilson S, Nadeau KC. Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects. Allergy Asthma Clin Immunol. 2014 May 12;10(1):25.
Jones PP, Nadeau KC. Introduction to the special issue on Stanford Immunology. Immunol Res. 2014 May;58(2-3):161-3.
Pellerin L, Jenks JA, Bégin P, Bacchetta R, Nadeau KC. Regulatory T cells and their roles in immune dysregulation and allergy. Immunol Res. 2014 May;58(2-3):358-68.
Klingbeil EC, Hew KM, Nygaard UC, Nadeau KC. Polycyclic aromatic hydrocarbons, tobacco smoke, and epigenetic remodeling in asthma. Immunol Res. 2014 May;58(2-3):369-73.
Bégin P, Dominguez T, Wilson SP, Bacal L, Mehrotra A, Kausch B, Trela A, Tavassoli M, Hoyte E, O'Riordan G, Blakemore A, Seki S, Hamilton RG, Nadeau KC. Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab. Allergy, Asthma, and Clinical Immunology. 2014 Feb 20;10(1):7.
Syed A, Garcia M, Kohli A, Maecker H, Tsai M, Galli S, and Nadeau KC. Peanut oral immunotherapy results in increased antigen-induced Treg function and hypomethylation of FOXP3. The Journal of Allergy and Clinical Immunology. 2014 Feb;133(2):500-10.
Kanai T, Jenks J, Seki S, Bacchetta R, and Nadeau KC. Identification of STAT5A and STAT5B Target Genes in Human T cells. PLoS One. 2014 Jan 30;9(1):e86790.
Bégin P, Winterroth LC, Dominguez T, Wilson SP, Bacal L, Mehrotra A, Kausch B, Trela A, Hoyte E, O'Riordan G, Seki S, Blakemore A, Woch M, Hamilton RG, Nadeau KC. Safety and feasibility of oral immunotherapy to multiple allergens for food allergy. Allergy, Asthma, and Clinical Immunology. 2014 Jan 15;10(1):1.

2013 Publications

Liu, J, Zhang, L, Winterroth, L, Garcia, M, Weiman, S, Wong, J, Sunwoo, J, and Nadeau, KC. Epigenetically-mediated pathogenic effects of phenanthrene on regulatory T cells. J Toxicol. 2013; 967-981.
Reber LL, Marichal T, Mukai K, Kita Y, Tokuoka SM, Roers A, Hartmann K, Karasuyama H, Nadeau KC, Tsai M, Galli SJ. Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice. J Allergy Clin Immunol. 2013 Oct;132(4):881-8. *Participated in obtaining funding, analysis and interpretation of data.
Syed A, Kohli A, and Nadeau KC. Food allergy diagnosis and therapy: where are we now? Immunotherapy. 2013 Sep; 5(9):931-44.
Chen R, Giliani S, Lanzi G, Mias GI, Lonardi S, Dobbs K, Manis J, Im H, Gallagher JE, Phanstiel DH, Euskirchen G, Lacroute P, Bettinger K, Moratto D, Weinacht K, Montin D, Gallo E, Mangili G, Porta F, Notarangelo LD, Pedretti S, Al-Herz W, Alfahdli W, Comeau AM, Traister RS, Pai SY, Carella G, Facchetti F, Nadeau KC, Snyder M, Notarangelo LD. Whole-exome sequencing identifies tetratricopeptide repeat domain 7A (TTC7A) mutations for combined immunodeficiency with intestinal atresias. J Allergy Clin Immunol. 2013 Sep;132(3):656-664. *Participated in acquisition of data, and analysis and interpretation of data.
Syed, A, Hew K, Kohli A, Knowlton G, Nadeau KC. Air Pollution and Epigenetics. Journal of Environmental Protection. 2013 Aug; 4:8A, 114-122.
Jenks JA, Seki S, Kanai T, Huang J, Morgan AA, Scalco RC, Nath R, Bucayu R, Wit JM, Al-Herz W, Ramadan D, Jorge AA, Bacchetta R, Hwa V, Rosenfeld R, Nadeau KC. Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells. Clin Immunol. 2013 Aug;148(2):227-36.
Dominguez TL, Bégin P, Nadeau KC. The use of epinephrine in acute allergic reaction to food. Pediatric Annals. 2013 Jul;42(7):293-5.
Bégin P, Nadeau KC. Diagnosis of food allergy. Pediatr Ann. 2013 Jun 1;42(6):102-9.
Iyengar SR, Hoyte EG, Loza A, Bonaccorso S, Chiang D, Umetsu DT, Nadeau KC. Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: a randomized, placebo-controlled clinical trial. Int Arch Allergy Immunol. Jun 2013;162(1):89-93
Ma J, Strub P, Lavori PW, Buist AS, Camargo CA Jr, Nadeau KC, Wilson SR, Xiao L. DASH for asthma: A pilot study of the DASH diet in not-well-controlled adult asthma. Contemporary Clinical Trials. 2013 May 3. *Participated in acquisition of data, analysis and interpretation of data, technical, and material support.
Le-Carlson M, Seki S, Abarbanel D, Quiros A, Cox K, and Nadeau KC. Markers of antigen presentation and activation on eosinophils and T-cells in the esophageal tissue of patients with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):257-62.
Abarbanel DN, Seki SM, Davies Y, Marlen N, Benavides JA, Cox K, Nadeau KC, Cox KL. Immunomodulatory Effect of Vancomycin on Treg in Pediatric Inflammatory Bowel Disease and Primary Sclerosing Cholangitis. J Clin Immunol. 2013 Feb;33(2):397-406. *Participated in acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision of the manuscript for important intellectual content, technical support, material support, and statistical analysis.

2012 Publications

Runyon RS, Cachola LM, Rajeshuni N, Hunter T, Garcia M, Ahn R, Lurmann F, Krasnow R, Jack LM, Miller RL, Swan GE, Kohli A, Jacobson AC, and Nadeau KC. Asthma discordance in twins is linked to epigenetic modifications of T cells. PLoS One. 2012;7(11): p. 487-496.
Kanai T, Jenks J, Nadeau KC. The STAT5b pathway defect and Autoimmunity. Frontiers in Immunology. 2012; 3:234.
Kohli, A, Garcia, M, Miller, R, Maher, C, Humblet, O, Hammond, K, and Nadeau, KC. Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children. J. of Clinical Epigenetics. 2012 Sep 25;4(1):17. 2012.
Swamy RS, Reshamwala N, Hunter T, Vissamsetti S, Santos CB, Baroody FM, Hwang PH, Hoyte EG, Garcia MA, Nadeau KC. Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy. J Allergy Clin Immunol. 2012 Jul;130(1):215-224. (Recommended by Faculty 1000)
Yu GP, Weldon B, Neale-May S, Nadeau KC. The Safety of Peanut Oral Immunotherapy in Peanut-Allergic Subjects in a Single-Center Trial. Int Arch Allergy Immunol. 2012 Jun 1;159(2):179-182.
Gernez Y, Tirouvanziam R, Reshamwala N, Yu G, Weldon BC, Galli SJ, Herzenberg LA, Nadeau KC. Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients. J Clin Immunol. 2012 Jun;32(3):565-73.
Bedoret D, Singh AK, Shaw V, Hoyte EG, Hamilton R, DeKruyff RH, Schneider LC, Nadeau KC (co-senior author), Umetsu DT. Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab. Mucosal Immunol. 2012 May;5(3):267-76.
Morgan AA, Pyrgos VJ, Nadeau KC, Williamson PR, Butte AJ. Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction. J Am Med Inform Assoc. 2012 Mar-Apr;19(2):284-8. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012 Mar 16;148(6):1293-307. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Recher M, Burns S, de la Fuente MA, Volpi S, Dahlberg C, Walter J, Moffitt K, Matthew D, Honke N, Lang, P, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau KC, Bouma G, Delmonte O, Frugoni F, Fomin A, Buchbinder D, Lundequist E-M, Massaad MJ, Tsokos G, Hartwig J, Manis J, Terhorst C, Geha R, Snapper S, Lang K, Malley R, Westerberg L, Thrasher A, Notarangelo L. B-cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22;119(12):2819-28. *Participated in enrolling patients in the study, and analysis and interpretation of data.
Pedroza L, Kumar V, Mace E, Nadeau KC, Perez E, Ruuskanen O, Orange J. AIRE contributes to Dectin-1-induced TNF-a production 1 and complexes with CARD9, Syk, and Dectin-1. J Allergy Clin Immunol. 2012 Feb;129(2):464-72. *Participated in enrolling patients in the study and analysis and interpretation of data.
Nadeau KC, Kohli A, Iyengar S, DeKruyff RH, Umetsu DT. Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy. Immunol Allergy Clin North Am. 2012 Feb;32(1):111-33.

Seed Grant Recipients

2015

Dr. Ruchi Gupta
Dr. Mubeccal Akdis

2016

Dr. Jayakar Nayak
Dr. Julie Parsonnet

2017

Dr. Stephen Luby
Dr. Justin Sonnenberg and Dr. Christopher Gardner

2018

Dr. Hans Oettgen
Dr. Gary Darmstadt

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