Nodal Marginal Zone B Cell Lymphoma
Supplemental Studies
Immunohistology and Flow Cytometry
- B lineage 100%
- Immunoglobulin light and heavy chains variably detectable
- More frequently detectable in plasmacytoid cases
- IgD reported in some cases
- CD23 8%
- CD5 negative
- CD43 35%
- bcl1 negative
- CD10 2%
- bcl2 65-90%
- bcl6 negative
- Cases with transformation to diffuse large cell lymphoma maintain CD5 and CD10 negativity
- CD138 can be extensive if plasmacytoid differentiation is prominent
