Plasma Cell Myeloma

Clinical

15% of all hematologic malignancies
Median age 69 years
Median survival 3 years
- May present with / cause bone pain, pathologic fractures, renal failure, hypercalcemia, recurrent infections due to hypogammaglobulinemia
Non-secretory variant (1%)
- No M protein
- Less renal damage
Asymptomatic/smoldering myeloma
- Minority of patients
- Initially 10 % annual progression to myeloma
Plasma cell leukemia
- >20% circulating plasma cells
- Poor survival