Maddalena Adorno
1. Position in the laboratory
Instructor
madorno@stanford.edu
2. Previous affiliations:
University of Padova, Italy (PhD school in Biosciences)
3. Current Projects:
Role of Usp16 in Down Syndrome
Regulation of Breast Cancer Protection
Oxidative stress in Down syndrome and Neurodegenerative diseases
Modeling of human pancreatic cancer
4. Interesting facts and hobbies:
Photography, Cooking, Reading and lots of Bikram
5. Publications:
Usp16 contributes to somatic stem-cell defects in Down's syndrome. Adorno M, Sikandar S, Mitra SS, Kuo A, Nicolis Di Robilant B, Haro-Acosta V, Ouadah Y, Quarta M, Rodriguez J, Qian D, Reddy VM, Cheshier S, Garner CC, Clarke MF.Nature. 2013 Sep 19;501(7467):380-4. doi: 10.1038/nature12530. Epub 2013 Sep 11.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.Willingham SB, Volkmer JP, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, Wang J, Contreras-Trujillo H, Martin R, Cohen JD, Lovelace P, Scheeren FA, Chao MP, Weiskopf K, Tang C, Volkmer AK, Naik TJ, Storm TA, Mosley AR, Edris B, Schmid SM, Sun CK, Chua MS, Murillo O, Rajendran P, Cha AC, Chin RK, Kim D, Adorno M, Raveh T, Tseng D, Jaiswal S, Enger PØ, Steinberg GK, Li G, So SK, Majeti R, Harsh GR, van de Rijn M, Teng NN, Sunwoo JB, Alizadeh AA, Clarke MF, Weissman IL., Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6662-7. doi: 10.1073/pnas.1121623109. Epub 2012 Mar
MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. Ooi AG, Sahoo D, Adorno M, Wang Y, Weissman IL, Park CY. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21505-10. doi: 10.1073/pnas.1016218107. Epub 2010 Nov 30.
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models.Liu H, Patel MR, Prescher JA, Patsialou A, Qian D, Lin J, Wen S, Chang YF, Bachmann MH, Shimono Y, Dalerba P, Adorno M, Lobo N, Bueno J, Dirbas FM, Goswami S, Somlo G, Condeelis J, Contag CH, Gambhir SS, Clarke MF., Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18115-20. doi: 10.1073/pnas.1006732107. Epub 2010 Oct 4.
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Bobisse S, Rondina MB, Guzzardo V, Parenti AR, Rosato A, Bicciato S, Balmain A, Piccolo S., Cell. 2009 Apr 3;137(1):87-98. doi: 10.1016/j.cell.2009.01.039.
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S., Cell. 2009 Jan 9;136(1):123-35. doi: 10.1016/j.cell.2008.10.051.
MicroRNA control of Nodal signalling. Martello G, Zacchigna L, Inui M, Montagner M, Adorno M, Mamidi A, Morsut L, Soligo S, Tran U, Dupont S, Cordenonsi M, Wessely O, Piccolo S., Nature. 2007 Sep 13;449(7159):183-8. Epub 2007 Aug 29.
Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation. Cordenonsi M, Montagner M, Adorno M, Zacchigna L, Martello G, Mamidi A, Soligo S, Dupont S, Piccolo S., Science. 2007 Feb 9;315(5813):840-3. Epub 2007 Jan 18.
Emilin1 links TGF-beta maturation to blood pressure homeostasis. Zacchigna L, Vecchione C, Notte A, Cordenonsi M, Dupont S, Maretto S, Cifelli G, Ferrari A, Maffei A, Fabbro C, Braghetta P, Marino G, Selvetella G, Aretini A, Colonnese C, Bettarini U, Russo G, Soligo S, Adorno M, Bonaldo P, Volpin D, Piccolo S, Lembo G, Bressan GM. Cell. 2006 Mar 10;124(5):929-42.
Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M, Piccolo S., Cell. 2005 Apr 8;121(1):87-99.
Convergence of p53 and TGF-beta signaling networks. Dupont S, Zacchigna L, Adorno M, Soligo S, Volpin D, Piccolo S, Cordenonsi M.,Cancer Lett. 2004 Sep 30;213(2):129-38. Review.
