Small Molecules

Pharmacokinetics is the study of the time course of a new chemical entity introduced into the body by different routes of administration e.g. intravenous, oral, subcutaneous etc. It is important to quantitatively measure drug concentrations at site of action to understand drug effect in the body. Custom LC-MS/MS methods are designed to measure concentrations of new chemical entities in plasma or other biological matrices. LC - triple quadrupole mass spectrometers are used. General PK calculations can be performed.

Full scan and fragmentation pattern of compounds of interest is performed to assist with structure characterization/elucidation. Ion trap mass spectrometers are used. Data analysis and data report is prepared upon completion of experiment.

Non targeted metabolomics analysis is performed using extracts from biological cell, tissue, organ or organism. Ion trap high resolution mass spectrometer combined with UPLC chromatography system is used. In some cases, when fragmentation is required for better interpretation, low resolution ion trap mass spectrometer instrument could be used.  Metabolite identification is performed by interpreting high resolution MS data and low resolution MS/MS fragmentation data (if applicable), searching against databases and comparing with authentic compounds.