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Frank M. Longo, MD, PhD
Memory disorders specialist
Practice Areas
Professional Education
- Board Certification: Neurology, American Board of Psychiatry and Neurology (1989)
- Residency: UCSF Medical Center (1987) CA
- Internship: New York VA Medical Center (1984) NY
- Ph.D., UC San Diego, Neuroscience (1983)
- Medical Education: UCSD School of Medicine (1981) CA
- M.D., UC San Diego, Medicine (1981)
- BA, UC San Diego, Biology (1977)
Honors & Awards
- First Place in Neuroscience, National Student Research Forum (1979)
- Edwin Boldrey Award for Basic Science Research, San Francisco Neurological Society (1990)
- Beeson Award, American Federation for Aging Research (1995)
- Associate Editor, Annals of Neurology (1994-1997)
- Outstanding Alumnus Award, UC San Diego (2000)
- Stanford University Fellow, Stanford University (2006-2008)
Administrative Appointments
- Chief, Neurology and Rehab Services, SF, VAMC (1995 - 2001)
- Assoc. Professor and Vice Chair, UC San Francisco (1996 - 1999)
- Assoc. Chief of Staff for Research and Dev., SF, VAMC (1997 - 2001)
- Professor and Vice Chair, UC San Francisco (1999 - 2001)
- Professor and Chair, Department of Neurology, University of North Carolina, Chapel Hill (2001 - 2005)
- Professor and Chair, Department of Neurology and Neurological Sciences, Stanford University (2006 - Present)
Publications
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B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke
Doyle, K. P., Quach, L. N., Sole, M., Axtell, R. C., Nguyen, T.-V. V., & Buckwalter, M. S. (2015). B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke. JOURNAL OF NEUROSCIENCE, 35(5), 2133-2145. -
PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease Using N-(2,5-Dimethoxybenzyl)-2-F-18-Fluoro-N-(2-Phenoxyphenyl)Acetamide
James, M. L., Belichenko, N. P., Nguyen, T.-V. V., Andrews, L. E., Ding, Z., & Chin, F. T. (2015). PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease Using N-(2,5-Dimethoxybenzyl)-2-F-18-Fluoro-N-(2-Phenoxyphenyl)Acetamide. JOURNAL OF NUCLEAR MEDICINE, 56(2), 311-316. -
Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury.
Xu, B., Park, D., Ohtake, Y., Li, H., Hayat, U., & Li, S. (2015). Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury. Neurobiology of disease, 73, 36-48. -
A strategy for analyzing bond strength and interaction kinetics between Pleckstrin homology domains and PI(4,5)P2 phospholipids using force distance spectroscopy and surface plasmon resonance
Malkovskiy, A. V., Wagh, D. A., LONGO, F. M., & Rajadas, J. (2015). A strategy for analyzing bond strength and interaction kinetics between Pleckstrin homology domains and PI(4,5)P2 phospholipids using force distance spectroscopy and surface plasmon resonance. ANALYST, 140(13), 4558-4565.
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Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR.
Friesland, A., Weng, Z., Duenas, M., Massa, S. M., Longo, F. M., & Lu, Q. (2014). Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR. Neurotoxicology, 45, 81-90.
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Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus.
Grabenstatter, H. L., Carlsen, J., Raol, Y. H., Yang, T., HUND, D., & Brooks-Kayal, A. R. (2014). Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. Journal of neuroscience research, 92(10), 1307-1318.
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A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome.
Kron, M., Lang, M., Adams, I. T., Sceniak, M., Longo, F., & Katz, D. M. (2014). A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome. Disease models & mechanisms, 7(9), 1047-1055.
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A Small Molecule p75(NTR) Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression
Simmons, D. A., Knowles, J. K., Belichenko, N. P., Banerjee, G., Finkle, C., & Longo, F. M. (2014). A Small Molecule p75(NTR) Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression. PLOS ONE, 9(8).
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Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., & Wyss-Coray, T. (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. NATURE MEDICINE, 20(6), 659-663.
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Small Molecule p75(NTR) Ligands Reduce Pathological Phosphorylation and Misfolding of Tau, Inflammatory Changes, Cholinergic Degeneration, and Cognitive Deficits in A beta PPL/S Transgenic Mice
Nguyen, T.-V. V., Shen, L., Vander Griend, L., Quach, L. N., Belichenko, N. P., & Longo, F. M. (2014). Small Molecule p75(NTR) Ligands Reduce Pathological Phosphorylation and Misfolding of Tau, Inflammatory Changes, Cholinergic Degeneration, and Cognitive Deficits in A beta PPL/S Transgenic Mice. JOURNAL OF ALZHEIMERS DISEASE, 42(2), 459-483.
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Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75(NTR.)
Friesland, A., Weng, Z., Duenas, M., Massa, S. M., Longo, F. M., & Lu, Q. (2014). Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75(NTR.). Neurotoxicology.
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Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75(NTR.)
Friesland, A., Weng, Z., Duenas, M., Massa, S. M., Longo, F. M., & Lu, Q. (2014). Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75(NTR.). Neurotoxicology.
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Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AßPP(L/S) transgenic mice.
Nguyen, T.-V. V., Shen, L., Vander Griend, L., Quach, L. N., Belichenko, N. P., & Longo, F. M. (2014). Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AßPP(L/S) transgenic mice. Journal of Alzheimer's disease : JAD, 42(2), 459-483.
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A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease
Simmons, D. A., Belichenko, N. P., Yang, T., Condon, C., Monbureau, M., & Longo, F. M. (2013). A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease. JOURNAL OF NEUROSCIENCE, 33(48), 18712-18727.
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A Small Molecule p75(NTR) Ligand Protects Neurogenesis After Traumatic Brain Injury
Shi, J., Longo, F. M., & Massa, S. M. (2013). A Small Molecule p75(NTR) Ligand Protects Neurogenesis After Traumatic Brain Injury. STEM CELLS, 31(11), 2561-2574.
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A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model
Knowles, J. K., Simmons, D. A., Nguyen, T.-V. V., Vander Griend, L., Xie, Y., & Longo, F. M. (2013). A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. NEUROBIOLOGY OF AGING, 34(8), 2052-2063.
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Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease
Longo, F. M., & Massa, S. M. (2013). Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. NATURE REVIEWS DRUG DISCOVERY, 12(7), 507-525.
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Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury
Tep, C., Lim, T. H., Ko, P. O., Getahun, S., Ryu, J. C., & Yoon, S. O. (2013). Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury. JOURNAL OF NEUROSCIENCE, 33(2), 397-410.
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Optimizing the use of CROs by academia and small companies.
Lane, R. F., Friedman, L. G., Keith, C., Braithwaite, S. P., Frearson, J. A., & Fillit, H. M. (2013). Optimizing the use of CROs by academia and small companies. Nature reviews. Drug discovery, 12(7), 487-8.
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Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic-Ischemic Stroke
Han, J., Pollak, J., Yang, T., Siddiqui, M. R., Doyle, K. P., & Buckwalter, M. S. (2012). Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic-Ischemic Stroke. STROKE, 43(7), 1918-1924.
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Suppression of Immunodeficiency Virus-Associated Neural Damage by the p75 Neurotrophin Receptor Ligand, LM11A-31, in an In Vitro Feline Model
Meeker, R. B., Poulton, W., Feng, W.-H., Hudson, L., & Longo, F. M. (2012). Suppression of Immunodeficiency Virus-Associated Neural Damage by the p75 Neurotrophin Receptor Ligand, LM11A-31, in an In Vitro Feline Model. JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 7(2), 388-400.
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Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function
Faizi, M., Bader, P. L., Saw, N., Nguyen, T.-V. V., Beraki, S., & Shamloo, M. (2012). Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function. BRAIN AND BEHAVIOR, 2(2), 142-154.
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A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome
Schmid, D. A., Yang, T., Ogier, M., Adams, I., Mirakhur, Y., & Katz, D. M. (2012). A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome. JOURNAL OF NEUROSCIENCE, 32(5), 1803-1810.
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Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors
Fisher, D., Xing, B., Dill, J., Li, H., Hoang, H. H., & Li, S. (2011). Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors. JOURNAL OF NEUROSCIENCE, 31(40), 14051-14066.
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LAR IS A FUNCTIONAL RECEPTOR FOR CSPG AXON GROWTH INHIBITORS
Li, S., Fisher, D., Xing, B., Li, H., Hoang, H., & Silver, J. (2011). LAR IS A FUNCTIONAL RECEPTOR FOR CSPG AXON GROWTH INHIBITORS. JOURNAL OF NEUROTRAUMA, 28(6), A2-A3.
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The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis
Bernabeu, R. O., & Longo, F. M. (2010). The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis. BMC NEUROSCIENCE, 11.
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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
Massa, S. M., Yang, T., Xie, Y., Shi, J., Bilgen, M., & Longo, F. M. (2010). Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. JOURNAL OF CLINICAL INVESTIGATION, 120(5), 1774-1785.
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The p75 Neurotrophin Receptor Promotes Amyloid-beta(1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo
Knowles, J. K., Rajadas, J., Nguyen, T.-V. V., Yang, T., LeMieux, M. C., & Longo, F. M. (2009). The p75 Neurotrophin Receptor Promotes Amyloid-beta(1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo. JOURNAL OF NEUROSCIENCE, 29(34), 10627-10637.
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Signaling Through Rho GTPase Pathway as Viable Drug Target
Lu, Q., Longo, F. M., Zhou, H., Massa, S. M., & Chen, Y.-H. (2009). Signaling Through Rho GTPase Pathway as Viable Drug Target. CURRENT MEDICINAL CHEMISTRY, 16(11), 1355-1365.
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Small Molecule, Non-Peptide p75(NTR) Ligands Inhibit A beta-Induced Neurodegeneration and Synaptic Impairment
Yang, T., Knowles, J. K., Lu, Q., Zhang, H., Arancio, O., & Longo, F. M. (2008). Small Molecule, Non-Peptide p75(NTR) Ligands Inhibit A beta-Induced Neurodegeneration and Synaptic Impairment. PLOS ONE, 3(11).
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A common motif targets huntingtin and the androgen receptor to the proteasome
Chandra, S., Shao, J., Li, J. X., Li, M., Longo, F. M., & Diamond, M. I. (2008). A common motif targets huntingtin and the androgen receptor to the proteasome. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(35), 23950-23955.
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Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants
James, S. E., Burden, H., Burgess, R., Xie, Y., Yang, T., & Lu, Q. (2008). Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants. NEUROTOXICOLOGY, 29(4), 605-612.
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Small Molecule Modulation of p75 Neurotrophin Receptor Functions
Longo, F. M., & Massa, S. M. (2008). Small Molecule Modulation of p75 Neurotrophin Receptor Functions. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 7(1), 63-70.
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E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner
Oblander, S. A., Ensslen-Craig, S. E., Longo, F. M., & Brady-Kalnay, S. M. (2007). E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner. MOLECULAR AND CELLULAR NEUROSCIENCE, 34(3), 481-492.
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Small molecule neurotrophin receptor ligands: Novel strategies for targeting Alzheimer's disease mechanisms
Longo, F. M., Yang, T., Knowles, J. K., Xie, Y., Moore, L. A., & Massa, S. M. (2007). Small molecule neurotrophin receptor ligands: Novel strategies for targeting Alzheimer's disease mechanisms. CURRENT ALZHEIMER RESEARCH, 4(5), 503-506.
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LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways
Yang, T., Massa, S. M., & Longo, F. M. (2006). LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways. JOURNAL OF NEUROBIOLOGY, 66(13), 1420-1436.
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Modulation of p75(NTR)-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain
Pehar, M., Cassina, P., Vargas, M. R., Xie, Y., Beckman, J. S., & Barbeito, L. (2006). Modulation of p75(NTR)-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain. EUROPEAN JOURNAL OF NEUROSCIENCE, 24(6), 1575-1580.
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Protein-tyrosine phosphatase (PTP) wedge domain peptides - A novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function
Xie, Y., Massa, S. M., Ensslen-Craig, S. E., Major, D. L., Yang, T., & Longo, F. M. (2006). Protein-tyrosine phosphatase (PTP) wedge domain peptides - A novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(24), 16482-16492.
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Small, nonpeptide p75(NTR) ligands induce survival signaling and inhibit proNGF-induced death
Massa, S. M., Xie, Y., Yang, T., Harrington, A. W., Kim, M. L., & Longo, F. M. (2006). Small, nonpeptide p75(NTR) ligands induce survival signaling and inhibit proNGF-induced death. JOURNAL OF NEUROSCIENCE, 26(20), 5288-5300.
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Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons
Bernabeu, R., Yang, T., Xie, Y. M., Mehta, B., Ma, S. Y., & Longo, F. M. (2006). Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons. MOLECULAR AND CELLULAR NEUROSCIENCE, 31(4), 723-738.
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Small molecule approaches for promoting neurogenesis.
Longo, F. M., Yang, T., Xie, Y., & Massa, S. M. (2006). Small molecule approaches for promoting neurogenesis. Current Alzheimer research, 3(1), 5-10.
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Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth
Yang, T., Yin, W. N., Derevyanny, V. D., Moore, L. A., & Longo, F. M. (2005). Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth. EUROPEAN JOURNAL OF NEUROSCIENCE, 22(9), 2159-2170.
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Neurotrophin receptor-based strategies for Alzheimer's disease.
Longo, F. M., & Massa, S. M. (2005). Neurotrophin receptor-based strategies for Alzheimer's disease. Current Alzheimer research, 2(2), 167-169.
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Neurotrophin Small Molecule Mimetics: Candidate Therapeutic Agents for Neurological Disorders
Longo FM, Xie Y, & Massa SM. (2005). Neurotrophin Small Molecule Mimetics: Candidate Therapeutic Agents for Neurological Disorders. Curr Med Chem - CNS Agents.
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Neurotrophin-based strategies for neuroprotection
Longo, F. M., & Massa, S. M. (2004). Neurotrophin-based strategies for neuroprotection. JOURNAL OF ALZHEIMERS DISEASE, 6(6), S13-S17.
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Neuroprotective strategies in Alzheimer's disease.
Longo, F. M., & Massa, S. M. (2004). Neuroprotective strategies in Alzheimer's disease. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, 1(1), 117-127.
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A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs
Zhang, C., Xie, Y. M., Martignetti, J. A., Yeo, T. T., Massa, S. M., & Longo, F. M. (2003). A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs. DNA AND CELL BIOLOGY, 22(5), 303-315.
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Leukocyte antigen-related protein tyrosine phosphatase receptor: A small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth
Yang, T., Bernabeu, R., Xie, Y. M., Zhang, J. S., Massa, S. M., & LONGO, F. M. (2003). Leukocyte antigen-related protein tyrosine phosphatase receptor: A small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth. JOURNAL OF NEUROSCIENCE, 23(8), 3353-3363.
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Alzheimer's therapeutics - Neurotrophin domain small molecule mimetics
Massa, S. M., Xie, Y. M., & LONGO, F. M. (2003). Alzheimer's therapeutics - Neurotrophin domain small molecule mimetics. JOURNAL OF MOLECULAR NEUROSCIENCE, 20(3), 323-326.
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Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation
Buttini, M., Yu, G. Q., Shockley, K., Huang, Y. D., Jones, B., & Mucke, L. (2002). Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. JOURNAL OF NEUROSCIENCE, 22(24), 10539-10548.
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ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury
Beattie, M. S., Harrington, A. W., LEE, R., Kim, J. Y., Boyce, S. L., & Yoon, S. O. (2002). ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. NEURON, 36(3), 375-386.
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Alzheimer's therapeutics - Neurotrophin small molecule mimetics
Massa, S. M., Xie, Y. M., & Longo, F. M. (2002). Alzheimer's therapeutics - Neurotrophin small molecule mimetics. JOURNAL OF MOLECULAR NEUROSCIENCE, 19(1-2), 107-111.
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Alzheimer's therapeutics: Neurotrophin small molecule mimetics
Massa, S. M., Xie, Y. M., & LONGO, F. M. (2002). Alzheimer's therapeutics: Neurotrophin small molecule mimetics. DRUG DISCOVERY AND DEVELOPMENT FOR ALZHEIMER'S DISEASE, 2000, 147-155.
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Psychological impact of news of genetic risk for Huntington disease
Horowitz, M. J., Field, N. P., Zanko, A., Donnelly, E. F., Epstein, C., & Longo, F. (2001). Psychological impact of news of genetic risk for Huntington disease. AMERICAN JOURNAL OF MEDICAL GENETICS, 103(3), 188-192.
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The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo
Xie, Y. M., Yeo, T. T., Zhang, C., Yang, T., Tisi, M. A., & Longo, F. M. (2001). The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo. JOURNAL OF NEUROSCIENCE, 21(14), 5130-5138.
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Stress induces zinc finger immediate early genes in the rat adrenal gland
Honkaniemi, J., Zhang, J. S., LONGO, F. M., & Sharp, F. R. (2000). Stress induces zinc finger immediate early genes in the rat adrenal gland. BRAIN RESEARCH, 877(2), 203-208.
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Nerve growth factor (NGF) loop 4 dimeric mimetics activate ERK and AKT and promote NGF-like neurotrophic effects
Xie, Y. M., Tisi, M. A., Yeo, T. T., & LONGO, F. M. (2000). Nerve growth factor (NGF) loop 4 dimeric mimetics activate ERK and AKT and promote NGF-like neurotrophic effects. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(38), 29868-29874.
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Downregulation of LAR tyrosine phosphatase prevents apoptosis and augments NGF-induced neurite outgrowth
Tisi, M. A., Xie, Y. M., Yeo, T. T., & Longo, F. M. (2000). Downregulation of LAR tyrosine phosphatase prevents apoptosis and augments NGF-induced neurite outgrowth. JOURNAL OF NEUROBIOLOGY, 42(4), 477-486.
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Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma
Yang, T., Martignetti, J. A., Massa, S. M., & Longo, F. M. (2000). Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma. CARCINOGENESIS, 21(2), 125-131.
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Neurotrophin small-molecule mimetics
Xie, Y. M., & LONGO, F. M. (2000). Neurotrophin small-molecule mimetics. NEURAL PLASTICITY AND REGENERATION, 128, 333-347.
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Gene expression along the cerebral-spinal axis after regional gene delivery
Meuli-Simmen, C., Liu, Y., Yeo, T. T., Liggitt, D., Tu, G. H., & Debs, R. J. (1999). Gene expression along the cerebral-spinal axis after regional gene delivery. HUMAN GENE THERAPY, 10(16), 2689-2700.
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Leukocyte common antigen-related tyrosine phosphatase receptor: Increased expression and neuronal-type splicing in breast cancer cells and tissue
Yang, T., Zhang, J. S., Massa, S. M., Han, X. L., & LONGO, F. M. (1999). Leukocyte common antigen-related tyrosine phosphatase receptor: Increased expression and neuronal-type splicing in breast cancer cells and tissue. MOLECULAR CARCINOGENESIS, 25(2), 139-149.
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Electromagnetic fields influence NGF activity and levels following sciatic nerve transection
Longo, F. M., Yang, T., Hamilton, S., Hyde, J. F., Walker, J., & Sisken, B. F. (1999). Electromagnetic fields influence NGF activity and levels following sciatic nerve transection. JOURNAL OF NEUROSCIENCE RESEARCH, 55(2), 230-237.
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LAR tyrosine phosphatase receptor: proximal membrane alternative splicing is coordinated with regional expression and intraneuronal localization
Honkaniemi, J., Zhang, J. S., Yang, T., Zhang, C., Tisi, M. A., & LONGO, F. M. (1998). LAR tyrosine phosphatase receptor: proximal membrane alternative splicing is coordinated with regional expression and intraneuronal localization. MOLECULAR BRAIN RESEARCH, 60(1), 1-12.
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LAR tyrosine phosphatase receptor: A developmental isoform is present in neurites and growth cones and its expression is regional- and cell-specific
Zhang, J. S., Honkaniemi, J., Yang, T., Yeo, T. T., & LONGO, F. M. (1998). LAR tyrosine phosphatase receptor: A developmental isoform is present in neurites and growth cones and its expression is regional- and cell-specific. MOLECULAR AND CELLULAR NEUROSCIENCE, 10(5-6), 271-286.
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LAR Tyrosine Phosphatase Receptor: A Developmental Isoform Is Present in Neurites and Growth Cones and Its Expression Is Regional- and Cell-Specific.
Zhang, J. S., Honkaniemi, J., Yang, T., Yeo, T. T., & Longo, F. M. (1998). LAR Tyrosine Phosphatase Receptor: A Developmental Isoform Is Present in Neurites and Growth Cones and Its Expression Is Regional- and Cell-Specific. Molecular and cellular neurosciences, 10(5/6), 271-86.
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Absence of p75(NTR) causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation
Yeo, T. T., CHUACOUZENS, J., Butcher, L. L., Bredesen, D. E., Cooper, J. D., & LONGO, F. M. (1997). Absence of p75(NTR) causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. JOURNAL OF NEUROSCIENCE, 17(20), 7594-7605.
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Trinucleotide repeats in transgenic mice: New insights
LONGO, F. M., & Massa, S. M. (1997). Trinucleotide repeats in transgenic mice: New insights. NEUROSCIENTIST, 3(5), 273-275.
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Aldose reductase inhibition increases CNTF-like bioactivity and protein in sciatic nerves from galactose-fed and normal rats
Mizisin, A. P., Calcutt, N. A., DiStefano, P. S., Acheson, A., & LONGO, F. M. (1997). Aldose reductase inhibition increases CNTF-like bioactivity and protein in sciatic nerves from galactose-fed and normal rats. DIABETES, 46(4), 647-652.
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Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism
LONGO, F. M., MANTHORPE, M., Xie, Y. M., & VARON, S. (1997). Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism. JOURNAL OF NEUROSCIENCE RESEARCH, 48(1), 1-17.
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Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation
Yeo, T. T., Yang, T., Massa, S. M., Zhang, J. S., Honkaniemi, J., & LONGO, F. M. (1997). Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation. JOURNAL OF NEUROSCIENCE RESEARCH, 47(3), 348-360.
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Minimized hormones grow in stature
LONGO, F. M., & Mobley, W. C. (1996). Minimized hormones grow in stature. NATURE BIOTECHNOLOGY, 14(9), 1092-1092.
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CLONING OF RAT GRP75, AN HSP70-FAMILY MEMBER, AND ITS EXPRESSION IN NORMAL AND ISCHEMIC BRAIN
Massa, S. M., LONGO, F. M., Zuo, J., Wang, S., Chen, J., & Sharp, F. R. (1995). CLONING OF RAT GRP75, AN HSP70-FAMILY MEMBER, AND ITS EXPRESSION IN NORMAL AND ISCHEMIC BRAIN. JOURNAL OF NEUROSCIENCE RESEARCH, 40(6), 807-819.
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LAR TYROSINE PHOSPHATASE RECEPTOR - ALTERNATIVE SPLICING IS PREFERENTIAL TO THE NERVOUS-SYSTEM, COORDINATED WITH CELL-GROWTH AND GENERATES NOVEL ISOFORMS CONTAINING EXTENSIVE CAG REPEATS
Zhang, J. S., & LONGO, F. M. (1995). LAR TYROSINE PHOSPHATASE RECEPTOR - ALTERNATIVE SPLICING IS PREFERENTIAL TO THE NERVOUS-SYSTEM, COORDINATED WITH CELL-GROWTH AND GENERATES NOVEL ISOFORMS CONTAINING EXTENSIVE CAG REPEATS. JOURNAL OF CELL BIOLOGY, 128(3), 415-431.
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WILL CILIARY NEUROTROPHIC FACTOR SLOW PROGRESSION OF MOTOR-NEURON DISEASE
LONGO, F. M. (1994). WILL CILIARY NEUROTROPHIC FACTOR SLOW PROGRESSION OF MOTOR-NEURON DISEASE. ANNALS OF NEUROLOGY, 36(2), 125-127.
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LEUKOCYTE COMMON ANTIGEN-RELATED RECEPTOR-LINKED TYROSINE PHOSPHATASE - REGULATION OF MESSENGER-RNA EXPRESSION
LONGO, F. M., Martignetti, J. A., LEBEAU, J. M., Zhang, J. S., Barnes, J. P., & Brosius, J. (1993). LEUKOCYTE COMMON ANTIGEN-RELATED RECEPTOR-LINKED TYROSINE PHOSPHATASE - REGULATION OF MESSENGER-RNA EXPRESSION. JOURNAL OF BIOLOGICAL CHEMISTRY, 268(35), 26503-26511.
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INDUCTION OF GLUCOSE-REGULATED PROTEIN (GRP78) AND INDUCIBLE HEAT-SHOCK PROTEIN (HSP70) MESSENGER-RNAS IN RAT-BRAIN AFTER KAINIC ACID SEIZURES AND FOCAL ISCHEMIA
Wang, S., LONGO, F. M., Chen, J., Butman, M., Graham, S. H., & Sharp, F. R. (1993). INDUCTION OF GLUCOSE-REGULATED PROTEIN (GRP78) AND INDUCIBLE HEAT-SHOCK PROTEIN (HSP70) MESSENGER-RNAS IN RAT-BRAIN AFTER KAINIC ACID SEIZURES AND FOCAL ISCHEMIA. NEUROCHEMISTRY INTERNATIONAL, 23(6), 575-582.
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CDNA CLONING AND EXPRESSION OF STRESS-INDUCIBLE RAT HSP70 IN NORMAL AND INJURED RAT-BRAIN
LONGO, F. M., Wang, S., Narasimhan, P., Zhang, J. S., Chen, J., & Sharp, F. R. (1993). CDNA CLONING AND EXPRESSION OF STRESS-INDUCIBLE RAT HSP70 IN NORMAL AND INJURED RAT-BRAIN. JOURNAL OF NEUROSCIENCE RESEARCH, 36(3), 325-335.
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PROLONGED INCREASES IN NEUROTROPHIC ACTIVITY ASSOCIATED WITH KAINATE-INDUCED HIPPOCAMPAL SYNAPTIC REORGANIZATION
Lowenstein, D. H., SEREN, M. S., & LONGO, F. M. (1993). PROLONGED INCREASES IN NEUROTROPHIC ACTIVITY ASSOCIATED WITH KAINATE-INDUCED HIPPOCAMPAL SYNAPTIC REORGANIZATION. NEUROSCIENCE, 56(3), 597-604.
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HEAT-SHOCK PROTEINS USED TO SHOW THAT HALOPERIDOL PREVENTS NEURONAL INJURY PRODUCED BY KETAMINE, MK801, AND PHENCYCLIDINE
Sharp, F. R., Butman, M., Wang, S., Koistinaho, J., Graham, S. H., & LONGO, F. M. (1993). HEAT-SHOCK PROTEINS USED TO SHOW THAT HALOPERIDOL PREVENTS NEURONAL INJURY PRODUCED BY KETAMINE, MK801, AND PHENCYCLIDINE. MARKERS OF NEURONAL INJURY AND DEGENERATION, 679, 288-290.
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HALOPERIDOL PREVENTS INDUCTION OF THE HSP70 HEAT-SHOCK GENE IN NEURONS INJURED BY PHENCYCLIDINE (PCP), MK801, AND KETAMINE
Sharp, F. R., Butman, M., Wang, S., Koistinaho, J., Graham, S. H., & LONGO, F. M. (1992). HALOPERIDOL PREVENTS INDUCTION OF THE HSP70 HEAT-SHOCK GENE IN NEURONS INJURED BY PHENCYCLIDINE (PCP), MK801, AND KETAMINE. JOURNAL OF NEUROSCIENCE RESEARCH, 33(4), 605-616.
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TROPHIC ACTIONS OF RECOMBINANT HUMAN NERVE GROWTH-FACTOR ON CULTURED RAT EMBRYONIC CNS CELLS
Knusel, B., BURTON, L. E., LONGO, F. M., Mobley, W. C., Koliatsos, V. E., & HEFTI, F. (1990). TROPHIC ACTIONS OF RECOMBINANT HUMAN NERVE GROWTH-FACTOR ON CULTURED RAT EMBRYONIC CNS CELLS. EXPERIMENTAL NEUROLOGY, 110(3), 274-283.
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DIRECT SEQUENCING OF PCR PRODUCTS USING THE MAXAM-GILBERT METHOD
Stamm, S., & LONGO, F. M. (1990). DIRECT SEQUENCING OF PCR PRODUCTS USING THE MAXAM-GILBERT METHOD. GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING, 7(5), 142-143.
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NERVE GROWTH-FACTOR INDUCES GENE-EXPRESSION OF THE PRION PROTEIN AND BETA-AMYLOID PROTEIN-PRECURSOR IN THE DEVELOPING HAMSTER CENTRAL-NERVOUS-SYSTEM
MCKINLEY, M. P., LONGO, F. M., Valletta, J. S., Rahbar, F., NEVE, R. L., & Mobley, W. C. (1990). NERVE GROWTH-FACTOR INDUCES GENE-EXPRESSION OF THE PRION PROTEIN AND BETA-AMYLOID PROTEIN-PRECURSOR IN THE DEVELOPING HAMSTER CENTRAL-NERVOUS-SYSTEM. PROGRESS IN BRAIN RESEARCH, 86, 227-238.
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THE INVITRO BIOLOGICAL EFFECT OF NERVE GROWTH-FACTOR IS INHIBITED BY SYNTHETIC PEPTIDES
LONGO, F. M., Vu, T. Kh., & Mobley, W. C. (1990). THE INVITRO BIOLOGICAL EFFECT OF NERVE GROWTH-FACTOR IS INHIBITED BY SYNTHETIC PEPTIDES. CELL REGULATION, 1(2), 189-195.
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DEVELOPMENTAL REGULATION OF NERVE GROWTH-FACTOR AND ITS RECEPTOR IN THE RAT CAUDATE PUTAMEN
Mobley, W. C., Woo, J. E., Edwards, R. H., Riopelle, R. J., LONGO, F. M., & Johnston, M. V. (1989). DEVELOPMENTAL REGULATION OF NERVE GROWTH-FACTOR AND ITS RECEPTOR IN THE RAT CAUDATE PUTAMEN. NEURON, 3(5), 655-664.
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NERVE REGENERATION THROUGH ARTIFICIAL TUBULAR IMPLANTS
Fields, R. D., LEBEAU, J. M., LONGO, F. M., & Ellisman, M. H. (1989). NERVE REGENERATION THROUGH ARTIFICIAL TUBULAR IMPLANTS. PROGRESS IN NEUROBIOLOGY, 33(2), 87-?.
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WHITE MATTER DISEASE IN AIDS - FINDINGS AT MR IMAGING
OLSEN, W. L., LONGO, F. M., Mills, C. M., & Norman, D. (1988). WHITE MATTER DISEASE IN AIDS - FINDINGS AT MR IMAGING. RADIOLOGY, 169(2), 445-448.
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DELAYED NERVE REGENERATION IN STREPTOZOTOCIN DIABETIC RATS
LONGO, F. M., Powell, H. C., Lebeau, J., Gerrero, M. R., Heckman, H., & Myers, R. R. (1986). DELAYED NERVE REGENERATION IN STREPTOZOTOCIN DIABETIC RATS. MUSCLE & NERVE, 9(5), 385-393.
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ABNORMAL NERVE REGENERATION IN GALACTOSE NEUROPATHY
Powell, H. C., LONGO, F. M., LEBEAU, J. M., & Myers, R. R. (1986). ABNORMAL NERVE REGENERATION IN GALACTOSE NEUROPATHY. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 45(2), 151-160.
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NEURONOTROPHIC ACTIVITIES IN CEREBROSPINAL-FLUID OF HEAD TRAUMA PATIENTS
LONGO, F. M., Selak, I., Zovickian, J., MANTHORPE, M., VARON, S., & U, H. S. (1984). NEURONOTROPHIC ACTIVITIES IN CEREBROSPINAL-FLUID OF HEAD TRAUMA PATIENTS. EXPERIMENTAL NEUROLOGY, 84(1), 207-218.
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NEURITE-PROMOTING FACTORS AND EXTRACELLULAR-MATRIX COMPONENTS ACCUMULATING INVIVO WITHIN NERVE REGENERATION CHAMBERS
LONGO, F. M., HAYMAN, E. G., Davis, G. E., RUOSLAHTI, E., ENGVALL, E., & VARON, S. (1984). NEURITE-PROMOTING FACTORS AND EXTRACELLULAR-MATRIX COMPONENTS ACCUMULATING INVIVO WITHIN NERVE REGENERATION CHAMBERS. BRAIN RESEARCH, 309(1), 105-117.
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TEMPORAL CHANGES OF NEURONOTROPHIC ACTIVITIES ACCUMULATING INVIVO WITHIN NERVE REGENERATION CHAMBERS
LONGO, F. M., Skaper, S. D., MANTHORPE, M., Williams, L. R., Lundborg, G., & VARON, S. (1983). TEMPORAL CHANGES OF NEURONOTROPHIC ACTIVITIES ACCUMULATING INVIVO WITHIN NERVE REGENERATION CHAMBERS. EXPERIMENTAL NEUROLOGY, 81(3), 756-769.
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SPATIAL-TEMPORAL PROGRESS OF PERIPHERAL-NERVE REGENERATION WITHIN A SILICONE CHAMBER - PARAMETERS FOR A BIOASSAY
Williams, L. R., LONGO, F. M., Powell, H. C., Lundborg, G., & VARON, S. (1983). SPATIAL-TEMPORAL PROGRESS OF PERIPHERAL-NERVE REGENERATION WITHIN A SILICONE CHAMBER - PARAMETERS FOR A BIOASSAY. JOURNAL OF COMPARATIVE NEUROLOGY, 218(4), 460-470.
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ENDOGENOUS AND EXOGENOUS FACTORS SUPPORT NEURONAL SURVIVAL AND CHOLINE-ACETYLTRANSFERASE ACTIVITY IN EMBRYONIC SPINAL-CORD CULTURES
MANTHORPE, M., Luyten, W., LONGO, F. M., & VARON, S. (1983). ENDOGENOUS AND EXOGENOUS FACTORS SUPPORT NEURONAL SURVIVAL AND CHOLINE-ACETYLTRANSFERASE ACTIVITY IN EMBRYONIC SPINAL-CORD CULTURES. BRAIN RESEARCH, 267(1), 57-66.
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LAMININ PROMOTES NEURITIC REGENERATION FROM CULTURED PERIPHERAL AND CENTRAL NEURONS
MANTHORPE, M., ENGVALL, E., RUOSLAHTI, E., LONGO, F. M., Davis, G. E., & VARON, S. (1983). LAMININ PROMOTES NEURITIC REGENERATION FROM CULTURED PERIPHERAL AND CENTRAL NEURONS. JOURNAL OF CELL BIOLOGY, 97(6), 1882-1890.
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NEURONOTROPHIC ACTIVITY IN BRAIN WOUNDS OF THE DEVELOPING RAT - CORRELATION WITH IMPLANT SURVIVAL IN THE WOUND CAVITY
MANTHORPE, M., NIETOSAMPEDRO, M., Skaper, S. D., Lewis, E. R., Barbin, G., & VARON, S. (1983). NEURONOTROPHIC ACTIVITY IN BRAIN WOUNDS OF THE DEVELOPING RAT - CORRELATION WITH IMPLANT SURVIVAL IN THE WOUND CAVITY. BRAIN RESEARCH, 267(1), 47-56.
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NEURONOTROPHIC ACTIVITIES ACCUMULATE INVIVO WITHIN SILICONE NERVE REGENERATION CHAMBERS
LONGO, F. M., MANTHORPE, M., Skaper, S. D., Lundborg, G., & VARON, S. (1983). NEURONOTROPHIC ACTIVITIES ACCUMULATE INVIVO WITHIN SILICONE NERVE REGENERATION CHAMBERS. BRAIN RESEARCH, 261(1), 109-116.
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Spinal cord neuronotrophic factors (SCNTFs): I. Bioassay of schwannoma and other conditioned media.
LONGO, F. M., MANTHORPE, M., & VARON, S. (1982). Spinal cord neuronotrophic factors (SCNTFs): I. Bioassay of schwannoma and other conditioned media. Brain research, 255(2), 277-294.
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INVIVO REGENERATION OF CUT NERVES ENCASED IN SILICONE TUBES - GROWTH ACROSS A 6-MILLIMETER GAP
Lundborg, G., Gelberman, R. H., LONGO, F. M., Powell, H. C., & VARON, S. (1982). INVIVO REGENERATION OF CUT NERVES ENCASED IN SILICONE TUBES - GROWTH ACROSS A 6-MILLIMETER GAP. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 41(4), 412-422.
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BRAIN INJURY CAUSES A TIME-DEPENDENT INCREASE IN NEURONOTROPHIC ACTIVITY AT THE LESION SITE
NIETOSAMPEDRO, M., Lewis, E. R., Cotman, C. W., MANTHORPE, M., Skaper, S. D., & VARON, S. (1982). BRAIN INJURY CAUSES A TIME-DEPENDENT INCREASE IN NEURONOTROPHIC ACTIVITY AT THE LESION SITE. SCIENCE, 217(4562), 860-861.
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COMPARATIVE FEATURES OF SPINAL NEURONOTROPHIC FACTORS IN FLUIDS COLLECTED INVITRO AND INVIVO
MANTHORPE, M., LONGO, F. M., & VARON, S. (1982). COMPARATIVE FEATURES OF SPINAL NEURONOTROPHIC FACTORS IN FLUIDS COLLECTED INVITRO AND INVIVO. JOURNAL OF NEUROSCIENCE RESEARCH, 8(2-3), 241-250.
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SPINAL-CORD NEURONOTROPHIC FACTORS (SCNTFS) .1. BIOASSAY OF SCHWANNOMA AND OTHER CONDITIONED MEDIA
LONGO, F. M., MANTHORPE, M., & VARON, S. (1982). SPINAL-CORD NEURONOTROPHIC FACTORS (SCNTFS) .1. BIOASSAY OF SCHWANNOMA AND OTHER CONDITIONED MEDIA. DEVELOPMENTAL BRAIN RESEARCH, 3(2), 277-294.
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NERVE REGENERATION MODEL AND TROPHIC FACTORS INVIVO
Lundborg, G., LONGO, F. M., & VARON, S. (1982). NERVE REGENERATION MODEL AND TROPHIC FACTORS INVIVO. BRAIN RESEARCH, 232(1), 157-161.
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Growth factors and motor neurons.
VARON, S., MANTHORPE, M., & LONGO, F. M. (1982). Growth factors and motor neurons. Advances in neurology, 36, 453-472.
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NERVE REGENERATION IN SILICONE CHAMBERS - INFLUENCE OF GAP LENGTH AND OF DISTAL STUMP COMPONENTS
Lundborg, G., Dahlin, L. B., Danielsen, N., Gelberman, R. H., LONGO, F. M., & VARON, S. (1982). NERVE REGENERATION IN SILICONE CHAMBERS - INFLUENCE OF GAP LENGTH AND OF DISTAL STUMP COMPONENTS. EXPERIMENTAL NEUROLOGY, 76(2), 361-375.
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NERVE REGENERATION ACROSS AN EXTENDED GAP - A NEUROBIOLOGICAL VIEW OF NERVE REPAIR AND THE POSSIBLE INVOLVEMENT OF NEURONOTROPHIC FACTORS
Lundborg, G., Dahlin, L. B., Danielsen, N., Hansson, H. A., Johannesson, A., & Engin, D. (1982). NERVE REGENERATION ACROSS AN EXTENDED GAP - A NEUROBIOLOGICAL VIEW OF NERVE REPAIR AND THE POSSIBLE INVOLVEMENT OF NEURONOTROPHIC FACTORS. JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 7(6), 580-587.
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RELATION OF SOMAL LIPID-SYNTHESIS TO THE FAST AXONAL-TRANSPORT OF PROTEIN AND LIPID
LONGO, F. M., & Hammerschlag, R. (1980). RELATION OF SOMAL LIPID-SYNTHESIS TO THE FAST AXONAL-TRANSPORT OF PROTEIN AND LIPID. BRAIN RESEARCH, 193(2), 471-485.
Patient Comments
Patients comments are gathered from our Patient Satisfaction Survey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
SHC Patient, Aug 2015
We travel approx, 800-900 miles R/T to see Dr. Longo and we have recommended him to others.
SHC Patient, Aug 2015
It's apparent that Dr. Longo constantly researches a cure for Alzheimer's. He's an expert in his work!
SHC Patient, Sep 2014
I am always grateful by my office visits to Dr. Longo.
SHC Patient, Apr 2014
Good experience.
SHC Patient, Mar 2014
Dr. Longo is an excellent doctor and wants to be sure any question we had were answered.
SHC Patient, Aug 2015
We travel approx, 800-900 miles R/T to see Dr. Longo and we have recommended him to others.
SHC Patient, Aug 2015
It's apparent that Dr. Longo constantly researches a cure for Alzheimer's. He's an expert in his work!
SHC Patient, Sep 2014
I am always grateful by my office visits to Dr. Longo.
SHC Patient, Apr 2014
Good experience.
SHC Patient, Mar 2014
Dr. Longo is an excellent doctor and wants to be sure any question we had were answered.