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Sean Mackey, M.D., Ph.D.
Pain specialist, Anesthesiologist
Redlich Professor and Professor, by courtesy, of Neurology at the Stanford University Medical Center
Bio:
Sean Mackey, M.D., Ph.D, is Chief of the Division of Pain Medicine and Redlich Professor of Anesthesiology, Perioperative and Pain Medicine, Neurosciences and Neurology at Stanford University. He is the Immediate Past President of the American Academy of Pain Medicine. Dr. Mackey received his BSE and MSE in Bioengineering from University of Pennsylvania and his PhD in Electrical and Computer Engineering as well as MD from University of Arizona. Dr. Mackey is author of over 200 journal articles, book chapters, abstracts, and popular press pieces in addition to numerous national and international lectures.
Under Dr. Mackey’s leadership, the Stanford Pain Management Center has been designated a Center of Excellence by the American Pain Society, one of only two centers to receive this honor twice. In 2011 he was a member of the Institutes of Medicine committee that issued the report on Relieving Pain in America. He is currently Co-Chair of the Oversight Committee for the NIH/Health and Human Services National Pain Strategy, an effort to establish a national health strategy for pain care, education and research.
Under Dr. Sean Mackey’s leadership, researchers at the Stanford Pain Management Center and the Stanford Systems Neuroscience and Pain Laboratory (SNAPL) have made major advances in the understanding of chronic pain as a disease in its own right, one that fundamentally alters the nervous system. Dr. Mackey has overseen efforts to map the specific brain and spinal cord regions that perceive and process pain, which has led to the development of a multidisciplinary treatment model that translates basic science research into innovative therapies to provide more effective, personalized treatments for patients with chronic pain.
Under Dr. Mackey’s leadership, the Stanford Pain Management Center has been designated a Center of Excellence by the American Pain Society, one of only two centers to receive this honor twice. In 2011 he was a member of the Institutes of Medicine committee that issued the report on Relieving Pain in America. He is currently Co-Chair of the Oversight Committee for the NIH/Health and Human Services National Pain Strategy, an effort to establish a national health strategy for pain care, education and research.
Under Dr. Sean Mackey’s leadership, researchers at the Stanford Pain Management Center and the Stanford Systems Neuroscience and Pain Laboratory (SNAPL) have made major advances in the understanding of chronic pain as a disease in its own right, one that fundamentally alters the nervous system. Dr. Mackey has overseen efforts to map the specific brain and spinal cord regions that perceive and process pain, which has led to the development of a multidisciplinary treatment model that translates basic science research into innovative therapies to provide more effective, personalized treatments for patients with chronic pain.
- 450 Broadway Street
- Pavilion A, 1st Floor
- Redwood City, CA 94063
- Phone: 650-723-6238
Practice Areas
Professional Education
- Internship: Tucson Hospitals Med Ed Prog (1995) AZ
- Medical Education: University of Arizona (1994) AZ
- Residency: Stanford University School of Medicine (1998) CA
- Fellowship: Stanford University School of Medicine (1999) CA
- Board Certification: Pain Management, American Board of Anesthesiology (2000)
- Board Certification: Anesthesia, American Board of Anesthesiology (1999)
- M.D., University of Arizona, Medicine (1994)
- Ph.D., University of Arizona, Electrical Engineering (1994)
- M.S.E, University of Pennsylvania, Bioengineering (1986)
- B.S.E., University of Pennsylvania, Bioengineering (1986)
Honors & Awards
- Characterization & Optimization of RF Catheter Ablation for the Treatment of Cardiac Arrhythmias, American Heart Association Fellowship (1990-1991)
- TV Catheter Delivery of Elec Energy to Ablate Arrhythmogenic Tissue..., Alpha Omega Alpha Honor Society Research Fellowship (1991-1992)
- Optimal Control of Transvenous Catheter Ablation in the Treatment of Tachyarrhythmias, NIH Short Term Research Fellowship (1989-1994)
- Electrical and Thermal Characterization of Radiofrequency Catheter Ablation, American College of Cardiology Research Grant (1994)
- Cognitive Neurosciences Grant, Clark Center for Bioengeneering, Biomedicine & Bioscience (2000)
- Top Doctors in America, Published in "Guide to Top Doctors" (2002)
- Teacher of the Month, Stanford Department of Anesthesia (2003)
- Dodie and John Rosekrans Pain Research Endowment Fund, Dodie and John Rosekrans Pain Research Endowment Fund (2001 - forever)
- Interventional Magnetic Resonance Imaging Applied to Regional Anesthesia and Pain Medicine, Stanford University (1999-2003)
- Processing of Pain in the Human Central Nervous System: Analysis through fMRI, Stanford Office of Technology Licensing Grant (2001-2004)
- Use of NMDA-Antagonists and Opiates in the Treatment of Fibromyalgia, Oxnard Foundation (2001-2004)
- Applications of Real Time fMRI, NIH R43MH067290 (2002-2004)
- Imaging Neural Systems in Complex Regional Pain Syndrome, Foundation for Anesthesia Education & Research (2004-2006)
- Development of a Human Neuropathic Pain Model, Stanford University (1999-2007)
- Fellowship Grant, Arthritis Foundation (2006-2007)
- Applications of Real Time fMRI-Phase II, NIH R44 NS050642 (2004-2007)
- Mechanisms of Analgesic Response During IV Lidocaine Infusion in Neuropathic Pain Patients, Foundation for Anesthesia Education and Research (2007-2008)
- Duloxetine: Functional MRI Neural Correlates of Efficacy in Patients with Chronic Low Back Pain, Eli Lilly (2006-2009)
- Low-Dose Naltrexone in the Treatment of Fibromyalgia, American Fibromyalgia Syndrome Association (2008-2009)
- Mechanisms of Opioid-Induced Hyperalgesia in Pain Patients: Examination via fMRI, NIH K99/R00 DA023609 (2007-2011)
- Prescription Opioid Use, Misuse, and Pain in Post-Surgical Patients, NIH K23 DA25152 (2008-2013)
- Development and Applications of Real Time fMRI Technology, Stanford Bio-X (2009-2010)
- Central Mechanisms of Urologic Pelvic Pain: Functional and Structural Analysis by MRI, NIH U01 DK082316 (2008-2013)
- fMRI of Pain in the Human Spinal Cord, NIH R01 NS053961 (2006-2010)
- Ellis Cohen Achievement Award, Department of Anesthesia, Stanford University (2010)
- Learned Control of Frontal and Limbic Systems via Real-Time fMRI, NIH R21 DA026092 (2009-2011)
- Chris Redlich Endowment in Pain Research, Chris Redlich Endowment Fund (2009-forever)
- Neuroimaging and Mentoring in Translational Pain Research, NIH K24 DA029262 (2010-2015)
- Stanford CAM Center for Chronic Back Pain Supplement, NIH P01 AT006651S1 (2011-2012)
- Stanford CAM Center for Chronic Back Pain, NIH P01 AT006651 (2011-2016)
- Clinical Center of Excellence, American Pain Society (2012)
- U.S. News and World Report Top 1% of Pain Management Specialists, U.S. News and World Report (2012)
- NIH Directors Award, National Institutes of Health (2015)
- Wilbert E. Fordyce Clinical Investigator Award, American Pain Society (2016)
Administrative Appointments
- Assistant Professor, Anesthesia & Pain Management, Neurosciences, Stanford University (1999 - 2007)
- Director (and Co-Founder), Regional Anesthesia Services (2000 - 2006)
- Director, Stanford Systems Neuroscience and Pain Lab (SNAPL) (2002 - Present)
- Associate Director, Pain Management Division, Stanford University (2004 - 2007)
- Co-Director, Stanford Pain Research and Clinical Center (SPARCC) (2004 - Present)
- Co-Director, Pain Working Group, Neuroscience Institute, Stanford University (2005 - Present)
- Associate Professor, Anesthesia & Pain Management, Neurosciences and (by courtesy) Neurology, Stanford University (2007 - 2012)
- Chief, Division of Pain Medicine, Stanford University (2007 - Present)
- Fellowship Program Director, Pain Medicine, Stanford University (2007 - Present)
- Redlich Professor, Anesthesia & Pain Management, Neurosciences and (by courtesy) Neurology, Stanford University (2012 - Present)
Publications
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The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network-a resting-state study from the MAPP Research Network
Martucci, K. T., Shirer, W. R., Bagarinao, E., Johnson, K. A., Farmer, M. A., & Mackey, S. C. (2015). The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network-a resting-state study from the MAPP Research Network. PAIN, 156(9), 1755-1764. -
Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network.
Sutcliffe, S., Bradley, C. S., Clemens, J. Q., James, A. S., Konkle, K. S., & Berry, S. H. (2015). Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network. International urogynecology journal, 26(7), 1047-1060. -
Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Network Neuroimaging Study
Farmer, M. A., Huang, L., Martucci, K., Yang, C. C., Maravilla, K. R., & Apkarian, A. V. (2015). Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Network Neuroimaging Study. JOURNAL OF UROLOGY, 194(1), 118-126. -
Nonlinear Effects of Noxious Thermal Stimulation and Working Memory Demands on Subjective Pain Perception
Sturgeon, J. A., Tieu, M. M., Jastrzab, L. E., McCue, R., Gandhi, V., & Mackey, S. C. (2015). Nonlinear Effects of Noxious Thermal Stimulation and Working Memory Demands on Subjective Pain Perception. PAIN MEDICINE, 16(7), 1301-1310.
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Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study.
Krieger, J. N., Stephens, A. J., Landis, J. R., Clemens, J. Q., Kreder, K., & Williams, D. A. (2015). Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study. journal of urology, 193(4), 1254-1262.
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Physical and psychological correlates of fatigue and physical function: a Collaborative Health Outcomes Information Registry (CHOIR) study.
Sturgeon, J. A., Darnall, B. D., Kao, M.-C. J., & Mackey, S. C. (2015). Physical and psychological correlates of fatigue and physical function: a Collaborative Health Outcomes Information Registry (CHOIR) study. journal of pain , 16(3), 291-8 e1.
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Report of the NIH Task Force on research standards for chronic low back pain.
Deyo, R. A., Dworkin, S. F., Amtmann, D., Andersson, G., Borenstein, D., & Weiner, D. K. (2015). Report of the NIH Task Force on research standards for chronic low back pain. Physical therapy, 95(2), e1-e18.
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Increased Brain Gray Matter in the Primary Somatosensory Cortex is Associated with Increased Pain and Mood Disturbance in Patients with Interstitial Cystitis/Painful Bladder Syndrome
Kairys, A. E., Schmidt-Wilcke, T., Puiu, T., Ichesco, E., Labus, J. S., & Harris, R. E. (2015). Increased Brain Gray Matter in the Primary Somatosensory Cortex is Associated with Increased Pain and Mood Disturbance in Patients with Interstitial Cystitis/Painful Bladder Syndrome. JOURNAL OF UROLOGY, 193(1), 131-137.
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Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study.
Kutch, J. J., Yani, M. S., Asavasopon, S., Kirages, D. J., Rana, M., & Mayer, E. A. (2015). Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study. NeuroImage. Clinical, 8, 493-502.
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Preliminary structural MRI based brain classification of chronic pelvic pain: A MAPP network study
Bagarinao, E., Johnson, K. A., Martucci, K. T., Ichesco, E., Farmer, M. A., & Mackey, S. (2014). Preliminary structural MRI based brain classification of chronic pelvic pain: A MAPP network study. PAIN, 155(12), 2502-2509.
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Focus article: report of the NIH task force on research standards for chronic low back pain
Deyo, R. A., Dworkin, S. F., Amtmann, D., Andersson, G., Borenstein, D., & Weiner, D. K. (2014). Focus article: report of the NIH task force on research standards for chronic low back pain. EUROPEAN SPINE JOURNAL, 23(10), 2028-2045.
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Alterations in Resting State Oscillations and Connectivity in Sensory and Motor Networks in Women with Interstitial Cystitis/Painful Bladder Syndrome
Kilpatrick, L. A., Kutch, J. J., Tillisch, K., Naliboff, B. D., Labus, J. S., & Mayer, E. A. (2014). Alterations in Resting State Oscillations and Connectivity in Sensory and Motor Networks in Women with Interstitial Cystitis/Painful Bladder Syndrome. JOURNAL OF UROLOGY, 192(3), 947-955.
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REPORT OF THE NATIONAL INSTITUTES OF HEALTH TASK FORCE ON RESEARCH STANDARDS FOR CHRONIC LOW BACK PAIN
Deyo, R. A., Dworkin, S. F., Amtmann, D., Andersson, G., Borenstein, D., & Weiner, D. K. (2014). REPORT OF THE NATIONAL INSTITUTES OF HEALTH TASK FORCE ON RESEARCH STANDARDS FOR CHRONIC LOW BACK PAIN. JOURNAL OF MANIPULATIVE AND PHYSIOLOGICAL THERAPEUTICS, 37(7), 449-467.
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The Appropriate Use of Neurostimulation of the Spinal Cord and Peripheral Nervous System for the Treatment of Chronic Pain and Ischemic Diseases: The Neuromodulation Appropriateness Consensus Committee
Deer, T. R., Mekhail, N., Provenzano, D., Pope, J., Krames, E., & North, R. (2014). The Appropriate Use of Neurostimulation of the Spinal Cord and Peripheral Nervous System for the Treatment of Chronic Pain and Ischemic Diseases: The Neuromodulation Appropriateness Consensus Committee. NEUROMODULATION, 17(6), 515-550.
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Focus Article Report of the NIH Task Force on Research Standards for Chronic Low Back Pain
Deyo, R. A., Dworkin, S. F., Amtmann, D., Andersson, G., Borenstein, D., & Weiner, D. K. (2014). Focus Article Report of the NIH Task Force on Research Standards for Chronic Low Back Pain. CLINICAL JOURNAL OF PAIN, 30(8), 701-712.
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In reply.
Schmidt, P. C., Ruchelli, G., Mackey, S. C., & Carroll, I. R. (2014). In reply. Anesthesiology, 121(2), 424-426.
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Report of the NIH Task Force on Research Standards for Chronic Low Back Pain
Deyo, R. A., Dworkin, S. F., Amtmann, D., Andersson, G., Borenstein, D., & Weiner, D. K. (2014). Report of the NIH Task Force on Research Standards for Chronic Low Back Pain. SPINE JOURNAL, 14(8), 1375-1391.
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Report of the NIH Task Force on Research Standards for Chronic Low Back Pain
Deyo, R. A., Dworkin, S. F., Amtmann, D., Andersson, G., Borenstein, D., & Weiner, D. K. (2014). Report of the NIH Task Force on Research Standards for Chronic Low Back Pain. PAIN MEDICINE, 15(8), 1249-1267.
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Report of the NIH Task Force on Research Standards for Chronic Low Back Pain
Deyo, R. A., Dworkin, S. F., Amtmann, D., Andersson, G., Borenstein, D., & Weiner, D. K. (2014). Report of the NIH Task Force on Research Standards for Chronic Low Back Pain. SPINE, 39(14), 1128-1143.
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Self-Loathing Aspects of Depression Reduce Postoperative Opioid Cessation Rate
Hah, J. M., Mackey, S., Barelka, P. L., Wang, C. Km., Wang, B. M., & Carroll, I. R. (2014). Self-Loathing Aspects of Depression Reduce Postoperative Opioid Cessation Rate. PAIN MEDICINE, 15(6), 954-964.
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Report of the NIH Task Force on Research Standards for Chronic Low Back Pain
Deyo, R. A., Dworkin, S. F., Amtmann, D., Andersson, G., Borenstein, D., & Weinertt, D. K. (2014). Report of the NIH Task Force on Research Standards for Chronic Low Back Pain. JOURNAL OF PAIN, 15(6), 569-585.
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Self-loathing aspects of depression reduce postoperative opioid cessation rate.
Hah, J. M., Mackey, S., Barelka, P. L., Wang, C. Km., Wang, B. M., & Carroll, I. R. (2014). Self-loathing aspects of depression reduce postoperative opioid cessation rate. Pain medicine , 15(6), 954-964.
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Preoccupation in an early-romantic relationship predicts experimental pain relief.
Nilakantan, A., Younger, J., Aron, A., & Mackey, S. (2014). Preoccupation in an early-romantic relationship predicts experimental pain relief. Pain medicine , 15(6), 947-953.
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Response to letter to the editor.
Dworkin, R. H., O'Connor, A. B., Kent, J., Mackey, S. C., Raja, S. N., & Wells, C. D. (2014). Response to letter to the editor. Pain, 155(5), 1045-1046.
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Multivariate Classification of Structural MRI Data Detects Chronic Low Back Pain
Ung, H., Brown, J. E., Johnson, K. A., Younger, J., Hush, J., & Mackey, S. (2014). Multivariate Classification of Structural MRI Data Detects Chronic Low Back Pain. CEREBRAL CORTEX, 24(4), 1037-1044.
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Complex Regional Pain Syndrome Is Associated With Structural Abnormalities in Pain-Related Regions of the Human Brain
Barad, M. J., Ueno, T., Younger, J., Chatterjee, N., & Mackey, S. (2014). Complex Regional Pain Syndrome Is Associated With Structural Abnormalities in Pain-Related Regions of the Human Brain. JOURNAL OF PAIN, 15(2), 197-203.
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Conditioned pain modulation is minimally influenced by cognitive evaluation or imagery of the conditioning stimulus.
Bernaba, M., Johnson, K. A., Kong, J.-T., & Mackey, S. (2014). Conditioned pain modulation is minimally influenced by cognitive evaluation or imagery of the conditioning stimulus. Journal of pain research, 7, 689-697.
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From Catastrophizing to Recovery: a pilot study of a single-session treatment for pain catastrophizing.
Darnall, B. D., Sturgeon, J. A., Kao, M.-C., Hah, J. M., & Mackey, S. C. (2014). From Catastrophizing to Recovery: a pilot study of a single-session treatment for pain catastrophizing. Journal of pain research, 7, 219-226.
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Proinflammatory cytokines and DHEA-S in women with fibromyalgia: impact of psychological distress and menopausal status.
Sturgeon, J. A., Darnall, B. D., Zwickey, H. L., Wood, L. J., Hanes, D. A., & Mackey, S. C. (2014). Proinflammatory cytokines and DHEA-S in women with fibromyalgia: impact of psychological distress and menopausal status. Journal of pain research, 7, 707-716.
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The MAPP research network: design, patient characterization and operations.
Landis, J. R., Williams, D. A., Lucia, M. S., Clauw, D. J., Naliboff, B. D., & Clemens, J. Q. (2014). The MAPP research network: design, patient characterization and operations. BMC urology, 14, 58-?.
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Optimizing real time fMRI neurofeedback for therapeutic discovery and development
Stoeckel, L. E., Garrison, K. A., Ghosh, S. S., Wighton, P., Hanlon, C. A., & Evins, A. E. (2014). Optimizing real time fMRI neurofeedback for therapeutic discovery and development. NEUROIMAGE-CLINICAL, 5, 245-255.
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Response to: Letter from Paul Eugene Summers, Federico Giove, and Carlo Adolfo Porro.
Nash, P., Glover, G., & Mackey, S. (2013). Response to: Letter from Paul Eugene Summers, Federico Giove, and Carlo Adolfo Porro. Pain, 154(11), 2574-2575.
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Interventional management of neuropathic pain: NeuPSIG recommendations
Dworkin, R. H., O'Connor, A. B., Kent, J., Mackey, S. C., Raja, S. N., & Wells, C. D. (2013). Interventional management of neuropathic pain: NeuPSIG recommendations. PAIN, 154(11), 2249-2261.
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Functional magnetic resonance imaging identifies somatotopic organization of nociception in the human spinal cord.
Nash, P., Wiley, K., Brown, J., Shinaman, R., Ludlow, D., & Mackey, S. (2013). Functional magnetic resonance imaging identifies somatotopic organization of nociception in the human spinal cord. Pain, 154(6), 776-781.
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Perioperative interventions to reduce chronic postsurgical pain.
Carroll, I., Hah, J., Mackey, S., Ottestad, E., Kong, J. T., & Curtin, C. (2013). Perioperative interventions to reduce chronic postsurgical pain. Journal of reconstructive microsurgery, 29(4), 213-222.
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Perioperative Interventions to Reduce Chronic Postsurgical Pain
Carroll, I., Hah, J., Mackey, S., Ottestad, E., Kong, J. T., & Curtin, C. (2013). Perioperative Interventions to Reduce Chronic Postsurgical Pain. JOURNAL OF RECONSTRUCTIVE MICROSURGERY, 29(4), 213-222.
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Central Neuroimaging of Pain
Mackey, S. C. (2013). Central Neuroimaging of Pain. JOURNAL OF PAIN, 14(4), 328-331.
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Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels.
Younger, J., Noor, N., McCue, R., & Mackey, S. (2013). Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels. Arthritis and rheumatism, 65(2), 529-538.
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Personalized Medicine and Opioid Analgesic Prescribing for Chronic Pain: Opportunities and Challenges
Bruehl, S., Apkarian, A. V., Ballantyne, J. C., Berger, A., Borsook, D., & Lin, Y. (2013). Personalized Medicine and Opioid Analgesic Prescribing for Chronic Pain: Opportunities and Challenges. JOURNAL OF PAIN, 14(2), 103-113.
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Understanding Central Mechanisms of Acupuncture Analgesia Using Dynamic Quantitative Sensory Testing: A Review
Kong, J.-T., Schnyer, R. N., Johnson, K. A., & Mackey, S. (2013). Understanding Central Mechanisms of Acupuncture Analgesia Using Dynamic Quantitative Sensory Testing: A Review. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
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Test-Retest Reliability of Thermal Temporal Summation Using an Individualized Protocol
Kong, J.-T., Johnson, K. A., Balise, R. R., & Mackey, S. (2013). Test-Retest Reliability of Thermal Temporal Summation Using an Individualized Protocol. JOURNAL OF PAIN, 14(1), 79-88.
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Development of the Stanford Expectations of Treatment Scale (SETS): A tool for measuring patient outcome expectancy in clinical trials
Younger, J., Gandhi, V., Hubbard, E., & Mackey, S. (2012). Development of the Stanford Expectations of Treatment Scale (SETS): A tool for measuring patient outcome expectancy in clinical trials. CLINICAL TRIALS, 9(6), 767-776.
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A Pilot Cohort Study of the Determinants of Longitudinal Opioid Use After Surgery
Carroll, I., Barelka, P., Wang, C. K. M., Wang, B. M., Gillespie, M. J., & Mackey, S. C. (2012). A Pilot Cohort Study of the Determinants of Longitudinal Opioid Use After Surgery. ANESTHESIA AND ANALGESIA, 115(3), 694-702.
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Real-time fMRI applied to pain management
Chapin, H., Bagarinao, E., & Mackey, S. (2012). Real-time fMRI applied to pain management. NEUROSCIENCE LETTERS, 520(2), 174-181.
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Sensory Pain Qualities in Neuropathic Pain
Mackey, S., Carroll, I., Emir, B., Murphy, T. K., Whalen, E., & Dumenci, L. (2012). Sensory Pain Qualities in Neuropathic Pain. JOURNAL OF PAIN, 13(1), 58-63.
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Strategy-dependent Dissociation of the Neural Correlates Involved in Pain Modulation
Lawrence, J. M., Hoeft, F., Sheau, K. E., & Mackey, S. C. (2011). Strategy-dependent Dissociation of the Neural Correlates Involved in Pain Modulation. ANESTHESIOLOGY, 115(4), 844-851.
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Towards a Physiology-Based Measure of Pain: Patterns of Human Brain Activity Distinguish Painful from Non-Painful Thermal Stimulation
Brown, J. E., Chatterjee, N., Younger, J., & Mackey, S. (2011). Towards a Physiology-Based Measure of Pain: Patterns of Human Brain Activity Distinguish Painful from Non-Painful Thermal Stimulation. PLOS ONE, 6(9).
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Prescription opioid analgesics rapidly change the human brain
Younger, J. W., Chu, L. F., D'Arcy, N. T., Trott, K. E., Jastrzab, L. E., & Mackey, S. C. (2011). Prescription opioid analgesics rapidly change the human brain. PAIN, 152(8), 1803-1810.
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Morphine and its metabolites after patient-controlled analgesia: considerations for respiratory depression
Sam, W. J., Mackey, S. C., Loetsch, J., & Drover, D. R. (2011). Morphine and its metabolites after patient-controlled analgesia: considerations for respiratory depression. JOURNAL OF CLINICAL ANESTHESIA, 23(2), 102-106.
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Human Response to Unintended Intrathecal Injection of Botulinum Toxin
Carroll, I., Fischbein, N., Barad, M., & Mackey, S. (2011). Human Response to Unintended Intrathecal Injection of Botulinum Toxin. PAIN MEDICINE, 12(7), 1094-1097.
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Development of a severity score for CRPS
Harden, R. N., Bruehl, S., Perez, R. Sgm., Birklein, F., Marinus, J., & Vatine, J.-J. (2010). Development of a severity score for CRPS. PAIN, 151(3), 870-876.
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Viewing Pictures of a Romantic Partner Reduces Experimental Pain: Involvement of Neural Reward Systems
Younger, J., Aron, A., Parke, S., Chatterjee, N., & Mackey, S. (2010). Viewing Pictures of a Romantic Partner Reduces Experimental Pain: Involvement of Neural Reward Systems. PLOS ONE, 5(10).
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Validation of proposed diagnostic criteria (the "Budapest Criteria") for Complex Regional Pain Syndrome
Harden, R. N., Bruehl, S., Perez, R. Sgm., Birklein, F., Marinus, J., & Vatine, J.-J. (2010). Validation of proposed diagnostic criteria (the "Budapest Criteria") for Complex Regional Pain Syndrome. PAIN, 150(2), 268-274.
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Chronic myofascial temporomandibular pain is associated with neural abnormalities in the trigeminal and limbic systems
Younger, J. W., Shen, Y. F., Goddard, G., & Mackey, S. C. (2010). Chronic myofascial temporomandibular pain is associated with neural abnormalities in the trigeminal and limbic systems. PAIN, 149(2), 222-228.
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Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions
Fredericks, C. A., Drabant, E. M., Edge, M. D., Tillie, J. M., Hallmayer, J., & Dhabhar, F. S. (2010). Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions. BRAIN BEHAVIOR AND IMMUNITY, 24(3), 350-357.
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Assessment and Treatment of Psychosocial Comorbidities in Patients With Neuropathic Pain
Turk, D. C., Audette, J., Levy, R. M., Mackey, S. C., & Stanos, S. (2010). Assessment and Treatment of Psychosocial Comorbidities in Patients With Neuropathic Pain. MAYO CLINIC PROCEEDINGS, 85(3), S42-S50.
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Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update
Dworkin, R. H., O'Connor, A. B., Audette, J., Baron, R., Gourlay, G. K., & Wells, C. D. (2010). Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update. MAYO CLINIC PROCEEDINGS, 85(3), S3-S14.
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A Novel CT-Guided Transpsoas Approach to Diagnostic Genitofemoral Nerve Block and Ablation
Parris, D., Fischbein, N., Mackey, S., & Carroll, I. (2010). A Novel CT-Guided Transpsoas Approach to Diagnostic Genitofemoral Nerve Block and Ablation. PAIN MEDICINE, 11(5), 785-789.
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Subcutaneous Injection of Botulinum Toxin A Is Beneficial in Postherpetic Neuralgia
Xiao, L., Mackey, S., Hui, H., Xong, D., Zhang, Q., & Zhang, D. (2010). Subcutaneous Injection of Botulinum Toxin A Is Beneficial in Postherpetic Neuralgia. PAIN MEDICINE, 11(12), 1827-1833.
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Pain Quality Predicts Lidocaine Analgesia among Patients with Suspected Neuropathic Pain
Carroll, I. R., Younger, J. W., & Mackey, S. C. (2010). Pain Quality Predicts Lidocaine Analgesia among Patients with Suspected Neuropathic Pain. PAIN MEDICINE, 11(4), 617-621.
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Randomized Clinical Trial of Acupuncture for Myofascial Pain of the Jaw Muscles
Shen, Y. F., Younger, J., Goddard, G., & Mackey, S. (2009). Randomized Clinical Trial of Acupuncture for Myofascial Pain of the Jaw Muscles. JOURNAL OF OROFACIAL PAIN, 23(4), 353-359.
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Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study
Younger, J., & Mackey, S. (2009). Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study. PAIN MEDICINE, 10(4), 663-672.
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Forebrain pain mechanisms
Neugebauer, V., Galhardo, V., Maione, S., & Mackey, S. C. (2009). Forebrain pain mechanisms. BRAIN RESEARCH REVIEWS, 60(1), 226-242.
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Sympathetic Block with Botulinum Toxin to Treat Complex Regional Pain Syndrome
Carroll, I., Clark, J. D., & Mackey, S. (2009). Sympathetic Block with Botulinum Toxin to Treat Complex Regional Pain Syndrome. ANNALS OF NEUROLOGY, 65(3), 348-351.
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Pain outcomes: A brief review of instruments and techniques
Younger, J., McCue, R., & Mackey, S. (2009). Pain outcomes: A brief review of instruments and techniques. CURRENT PAIN AND HEADACHE REPORTS, 13(1), 39-43.
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Spinal cord stimulation compared with medical management for failed back surgery syndrome
Coleman, S. D., & Mackey, S. (2009). Spinal cord stimulation compared with medical management for failed back surgery syndrome. CURRENT PAIN AND HEADACHE REPORTS, 13(1), 1-2.
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Serratus muscle stimulation effectively treats notalgia paresthetica caused by long thoracic nerve dysfunction: a case series.
Wang, C. K., Gowda, A., Barad, M., Mackey, S. C., & Carroll, I. R. (2009). Serratus muscle stimulation effectively treats notalgia paresthetica caused by long thoracic nerve dysfunction: a case series. Journal of brachial plexus and peripheral nerve injury, 4, 17-?.
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Reduced Cold Pain Tolerance in Chronic Pain Patients Following Opioid Detoxification
Younger, J., Barelka, P., Carroll, I., Kaplan, K., Chu, L., & Mackey, S. (2008). Reduced Cold Pain Tolerance in Chronic Pain Patients Following Opioid Detoxification. PAIN MEDICINE, 9(8), 1158-1163.
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Toward optimal health: A discussion on sex, gender, and pain
Godfrey, J. R., & Mackey, S. (2008). Toward optimal health: A discussion on sex, gender, and pain. JOURNAL OF WOMENS HEALTH, 17(6), 917-920.
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Your pain or mine? Common and distinct neural systems supporting the perception of pain in self and other
Ochsner, K. N., Zaki, J., Hanelin, J., Ludlow, D. H., Knierim, K., & Mackey, S. C. (2008). Your pain or mine? Common and distinct neural systems supporting the perception of pain in self and other. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 3(2), 144-160.
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Pulsed radiofrequency for chronic pain
Byrd, D., & Mackey, S. (2008). Pulsed radiofrequency for chronic pain. CURRENT PAIN AND HEADACHE REPORTS, 12(1), 37-41.
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Role of neuroimaging in analgesic drug development
Lawrence, J., & Mackey, S. C. (2008). Role of neuroimaging in analgesic drug development. DRUGS IN R&D, 9(5), 323-334.
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Mexiletine Therapy for Chronic Pain: Survival Analysis Identifies Factors Predicting Clinical Success.
Carroll, Kaplan, & Mackey. (2008). Mexiletine Therapy for Chronic Pain: Survival Analysis Identifies Factors Predicting Clinical Success. Journal of Pain and Symptom Management, 35(3).
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Multivariate analysis of chronic pain patients undergoing lidocaine infusions: Increasing pain severity and advancing age predict likelihood of clinically meaningful analgesia
Carroll, I., Gaeta, R., & Mackey, S. (2007). Multivariate analysis of chronic pain patients undergoing lidocaine infusions: Increasing pain severity and advancing age predict likelihood of clinically meaningful analgesia. CLINICAL JOURNAL OF PAIN, 23(8), 702-706.
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Different circuits for different pain: Patterns of functional connectivity reveal distinct networks for processing pain in self and others
Zaki, J., Ochsner, K. N., Hanellin, J., Wager, T. D., & Mackey, S. C. (2007). Different circuits for different pain: Patterns of functional connectivity reveal distinct networks for processing pain in self and others. SOCIAL NEUROSCIENCE, 2(3-4), 276-291.
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Pulsed radiofrequency for the treatment of chronic ilioinguinal neuropathy.
Mitra, R., Zeighami, A., & Mackey, S. (2007). Pulsed radiofrequency for the treatment of chronic ilioinguinal neuropathy. Hernia , 11(4), 369-371.
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Potential clinical applications for spinal functional MRI.
Kornelsen, J., & Mackey, S. (2007). Potential clinical applications for spinal functional MRI. Current pain and headache reports, 11(3), 165-170.
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Pharmacologic therapies for complex regional pain syndrome.
Mackey, S., & Feinberg, S. (2007). Pharmacologic therapies for complex regional pain syndrome. Current pain and headache reports, 11(1), 38-43.
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The role of adrenergic receptors and pain: The good, the bad, and the unknown.
Carroll I, Mackey S, & Gaeta R. (2007). The role of adrenergic receptors and pain: The good, the bad, and the unknown. Seminars in Anesthesia and Perioperative Pain, 26(1).
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Imaging the Spinal Cord
Mackey S. (2007). Imaging the Spinal Cord. Current Pain and Headache Reports (accepted).
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Neural correlates of individual differences in pain-related fear and anxiety
Ochsner, K. N., Ludlow, D. H., Knierim, K., Hanelin, J., Ramachandran, T., & Mackey, S. C. (2006). Neural correlates of individual differences in pain-related fear and anxiety. PAIN, 120(1-2), 69-77.
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Control over brain activation and pain learned by using real-time functional MRI
deCharms, R. C., Maeda, F., Glover, G. H., Ludlow, D., Pauly, J. M., & Mackey, S. C. (2005). Control over brain activation and pain learned by using real-time functional MRI. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(51), 18626-18631.
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A vaccine to prevent herpes zoster
Carroll, I., Gaeta, R., & Mackey, S. (2005). A vaccine to prevent herpes zoster. NEW ENGLAND JOURNAL OF MEDICINE, 353(13), 1414-1415.
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Continuous peripheral nerve blocks.
Shinaman, R. C., & Mackey, S. (2005). Continuous peripheral nerve blocks. Current pain and headache reports, 9(1), 24-29.
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Reflecting upon feelings: an fMRI study of neural systems supporting the attribution of emotion to self and other
Ochsner, K. N., Knierim, K., Ludlow, D. H., Hanelin, J., Ramachandran, T., & Mackey, S. C. (2004). Reflecting upon feelings: an fMRI study of neural systems supporting the attribution of emotion to self and other. JOURNAL OF COGNITIVE NEUROSCIENCE, 16(10), 1746-1772.
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Functional imaging and the neural systems of chronic pain
Mackey, S. C., & Maeda, F. (2004). Functional imaging and the neural systems of chronic pain. NEUROSURGERY CLINICS OF NORTH AMERICA, 15(3), 269-?.
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Mechanisms of inflammatory pain - Therapeutic implications
Mackey, S. (2004). Mechanisms of inflammatory pain - Therapeutic implications. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 10(3), S5-S11.
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Low Back Pain: Management Across a Spectrum of Presentations (book chapter)
Mackey S. (2004). Low Back Pain: Management Across a Spectrum of Presentations (book chapter). Current Issues in Pain Management for the Primary Care Physician.
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Mechanisms of inflammatory pain: therapeutic implications
Mackey S. (2004). Mechanisms of inflammatory pain: therapeutic implications. Journal of Clinical Rheumatology, 10(3S).
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Perioperative Pain Management (book chapter)
Mackey S, & Gaeta R. (2003). Perioperative Pain Management (book chapter). Anesthesiologist's Manual of Surgical Procedures, 3rd ed..
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MR guidance of sympathetic nerve blockade: Measurement of vasomotor response-initial experience in seven patients
Sze, D. Y., & Mackey, S. C. (2002). MR guidance of sympathetic nerve blockade: Measurement of vasomotor response-initial experience in seven patients. RADIOLOGY, 223(2), 574-580.
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Delayed subdural block after a stellate ganglion block
Leong, M. S., & Mackey, S. (2001). Delayed subdural block after a stellate ganglion block. ANESTHESIOLOGY, 94(2), 358-359.
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Selection and placement of the double-lumen tube in the Asian patient
Mackey S, & Brodsky JB. (1998). Selection and placement of the double-lumen tube in the Asian patient. Asian Cardiovascular & Thoracic Annals, 6(3).
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Selecting the correct size left double-lumen tube
Brodsky, J. B., & Cannon, W. B. (1997). Selecting the correct size left double-lumen tube. JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 11(7), 924-925.
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Bilateral vocal cord paralysis after radical cystectomy in a patient with a history of bulbar polio
Macario, A., Mackey, S., & Terris, D. (1997). Bilateral vocal cord paralysis after radical cystectomy in a patient with a history of bulbar polio. ANESTHESIA AND ANALGESIA, 85(5), 1171-1172.
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Reduction of propofol injection pain with a double lumen IV set
Angst, M. S., Mackey, S. C., Zupfer, G. H., Tataru, C. D., & BROCKUTNE, J. G. (1997). Reduction of propofol injection pain with a double lumen IV set. JOURNAL OF CLINICAL ANESTHESIA, 9(6), 462-466.
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Isolation techniques - adances in thoracic anesthesia and postoperative care
Brodsky JB, & Mackey S. (1997). Isolation techniques - adances in thoracic anesthesia and postoperative care. Seminars in Cardiothoracic and Vascular Anesthesia, 1(3).
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Simultaneous multipolar radiofrequency ablation in the monopolar mode increases lesion size
Mackey, S., Thornton, L., He, D. S., Marcus, F. I., & LAMPE, L. F. (1996). Simultaneous multipolar radiofrequency ablation in the monopolar mode increases lesion size. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 19(7), 1042-1048.
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Comparison of gold versus platinum electrodes on myocardial lesion size using radiofrequency energy
Simmons, W. N., Mackey, S., He, D. S., & Marcus, F. I. (1996). Comparison of gold versus platinum electrodes on myocardial lesion size using radiofrequency energy. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 19(4), 398-402.
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
