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Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma
This pilot phase I/II trial studies the side effects and best dose of plerixafor after
radiation therapy and temozolomide and to see how well it works in treating patients with
newly diagnosed high grade glioma. Plerixafor may stop the growth of tumor cells by blocking
blood flow to the tumor. Drugs used in chemotherapy, such as temozolomide, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Radiation therapy uses high energy x rays to kill tumor cells. Giving plerixafor
after radiation therapy and temozolomide may be an effective treatment for high grade
glioma.