Baltimore, MD— Reproduction is highly dependent on diet and the ability to use nutrients to grow and generate energy. This is clearly seen in women, who must provide all the nutritional building blocks required to support a growing embryo. As a result, metabolic diseases like diabetes and obesity...
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Stanford, CA— You’ve probably seen news stories about the highly lauded, much-discussed genome editing system CRISPR/Cas9. But did you know the system was actually derived from bacteria, which use it to fight off foreign invaders such as viruses? It allows many bacteria to snip and store segments of DNA from an invading virus, which they can then use to “remember” and destroy DNA from similar invaders if they are encountered again.

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Scientists have long been puzzled by Mercury’s very dark surface. Previously, scientists proposed that the darkness came from carbon accumulated by comet impacts. Now scientists, including Carnegie’s Larry Nittler, confirm that carbon is present at Mercury’s surface, but that it most likely originated deep below the surface, in the form of a now-disrupted and buried ancient graphite-rich crust, which was later brought to the surface via impacts after most of the current crust formed. 

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Metallic glasses are at the frontier of materials science research. They have been made by rapidly cooling alloys of various metals including, zirconium, palladium, iron, titanium, and copper, and used for a variety of applications from making golf clubs to aerospace construction. But much about them remains poorly understood. A team of scientists from Carnegie's Geophysical Laboratory is trying to unravel the mysteries of metallic glass.

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Baltimore, MD—New work from Carnegie’s Allan Spradling and Lei Lei demonstrates that mammalian egg cells gain crucial cellular components at an early stage from their undifferentiated sister cells, called germ cells. This mechanism had previously only been documented in lower animals, and may be a key to understanding the egg’s unique properties. Their work is published via Science First Release.

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  • Washington, D.C.—For the first time scientists have looked at the net balance of the three major greenhouse gases—carbon dioxide, methane, and nitrous oxide—for every region of Earth’s landmasses. They found surprisingly, that human-induced emissions of methane and nitrous oxide from ecosystems overwhelmingly surpass the ability of the land to soak up carbon dioxide emissions, which makes the terrestrial biosphere a contributor to climate change.

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The Energy Frontier Research in Extreme Environments Center (EFree) was established to accelerate the discovery and synthesis of kinetically stabilized, energy-related materials using extreme conditions. Partners in this Carnegie-led center include world-leading groups in five universities—Caltech...
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Monitoring tropical deforestation and forest degradation with satellites can be an everyday activity for non-experts who support environmental conservation, forest management, and resource policy development. Through extensive observation of user needs, the Greg Asner team developed CLASlite ( the...
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The Gall laboratory studies all aspects of the cell nucleus, particularly the structure of chromosomes, the transcription and processing of RNA, and the role of bodies inside the cell nucleus, especially the Cajal body (CB) and the histone locus body (HLB). Much of the work makes use of the giant...
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Capital Science Evening Lectures
Wednesday, April 13, 2016 -
6:45pm to 8:00pm

The MESSENGER spacecraft, the first to orbit...

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Special Events
Monday, May 9, 2016 -
6:30pm to 8:00pm

The genome editing system called CRISPR earned Science magazine’s “2015 Breakthrough of the Year.” The advent of facile genome engineering using the bacterial RNA-guided CRISPR-Cas9...

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Capital Science Evening Lectures
Wednesday, May 25, 2016 -
6:45pm to 8:00pm

What do fish fossils tell us about the human body? How can scientists predict where to...

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Frederick Tan holds a unique position at Embryology in this era of high-throughput sequencing where determining DNA and RNA sequences has become one of the most powerful technologies in biology. DNA provides the basic code shared by all our cells to program our development. While there are about 30...
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Galacticus is not a super hero; it’s a super model used to determine the formation and evolution of the galaxies. Developed by Andrew Benson, the George Ellery Hale Distinguished Scholar in Theoretical Astrophysics, it is one of the most advanced models of galaxy formation available. Rather than...
Meet this Scientist
Luis Ho is a world-renowned black hole expert. Using the Hubble Space Telescope, Ho and colleagues have discovered most of the known black holes in nearby galaxies. Once thought rare, Ho and team instead established that black holes are so common they are integral galactic components. Indeed, black...
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March 9, 2016

Washington, D.C.—For the first time scientists have looked at the net balance of the three major greenhouse gases—carbon dioxide, methane, and nitrous oxide—for every region of Earth’s landmasses. They found surprisingly, that human-induced emissions of methane and nitrous oxide from ecosystems overwhelmingly surpass the ability of the land to soak up carbon dioxide emissions, which makes the terrestrial biosphere a contributor to climate change. The results published in the March 10, 2016, Nature, revises our understanding of how human activity contributes to global warming.   

Co-author Anna Michalak of Carnegie’s Department of Global Ecology remarked, “Typically we think of

March 7, 2016

Washington, D.C.—Scientists have long been puzzled about what makes Mercury’s surface so dark. The innermost planet reflects much less sunlight than the Moon, a body on which surface darkness is controlled by the abundance of iron-rich minerals. These are known to be rare at Mercury’s surface, so what is the “darkening agent” there?

About a year ago, scientists proposed that Mercury’s darkness was due to carbon that gradually accumulated from the impact of comets that traveled into the inner Solar System. Now scientists, led by Patrick Peplowski of the Johns Hopkins University Applied Physics Laboratory, have used data from the MESSENGER mission* to confirm that a high abundance

Carnegie Science, Carnegie Institution, CRISPR, CRISPR/Cas, CRISPR/Cas9, Devaki Bhaya
March 2, 2016

Stanford, CA— You’ve probably seen news stories about the highly lauded, much-discussed genome editing system CRISPR/Cas9. But did you know the system was actually derived from bacteria, which use it to fight off foreign invaders such as viruses? It allows many bacteria to snip and store segments of DNA from an invading virus, which they can then use to “remember” and destroy DNA from similar invaders if they are encountered again. Recent work from a team of researchers including Carnegie’s Devaki Bhaya demonstrates that some bacteria also use the CRISPR/Cas system to snip and recognize segments of RNA, not just DNA. It was published by Science.

A quick primer on CRISPR/Cas

March 1, 2016

How big a role does ocean acidification play in the sickly state of many coral reefs? Science magazine reports on a new study from Ken Caldeira and Rebecca Albright that borrows from a common after-dinner practice: popping a Tums to neutralize the acid and isolate its effect on reef health. More

April 13, 2016

The MESSENGER spacecraft, the first to orbit the planet Mercury, overcame many technical challenges to survive the harsh environment of the inner solar system. Along the way, the mission's discoveries about one of our nearest planetary neighbors have changed our understanding of how the inner planets – including Earth – formed and evolved.

  Dr. Sean C. Solomon, Director, Lamont-Doherty Earth Observatory Associate Director for Earth Systems Science, Earth Institute William B. Ransford Professor of Earth and Planetary Science, Department of Earth and Environmental Sciences, Columbia University
May 9, 2016

The genome editing system called CRISPR earned Science magazine’s “2015 Breakthrough of the Year.” The advent of facile genome engineering using the bacterial RNA-guided CRISPR-Cas9 system in animals and plants is transforming biology. In this talk, CRISPR pioneer Jennifer Doudna presents a brief history of CRISPR biology from its initial discovery through the elucidation of the CRISPR-Cas9 enzyme mechanism, providing the foundation for remarkable developments using this technology to modify, regulate, or visualize genomic loci in a wide variety of cells and organisms. These results highlight a new era in which genomic manipulation is no longer a bottleneck to experiments, paving the way

May 25, 2016

What do fish fossils tell us about the human body? How can scientists predict where to find transitional fossils. Dr. Shubin will take us from the anatomy laboratory to the Arctic of Canada in search of answers.

Dr. Neil Shubin, Department of Organismal Biology and Anatomy, The University of Chicago

Carbon plays an unparalleled role in our lives: as the element of life, as the basis of most of society’s energy, as the backbone of most new materials, and as the central focus in efforts to understand Earth’s variable and uncertain climate. Yet in spite of carbon’s importance, scientists remain largely ignorant of the physical, chemical, and biological behavior of many of Earth’s carbon-bearing systems. The Deep Carbon Observatory (DCO) is a global research program to transform our understanding of carbon in Earth. At its heart, DCO is a community of scientists, from biologists to physicists, geoscientists to chemists, and many others whose work crosses these disciplinary lines,

Chris Field is a co-principal investigator of the Jasper Ridge Global Change Experiment at the Jasper Ridge Biological Preserve in northern California. The site, designed to exploit grasslands as models for understanding how ecosystems may respond to climate change, hosts a number of studies of the potential effects from elevated atmospheric carbon dioxide, elevated temperature, increased precipitation, and increased nitrogen deposition. The site houses experimental plots that replicate all possible combinations of the four treatments and additional sampling sites that control for the effects of project infrastructure. Studies focus on several integrated ecosystem responses to the

Stem cells make headline news as potential treatments for a variety of diseases. But undertstanding the nuts and bolts of how they develop from an undifferentiated cell  that gives rise to cells that are specialized such as organs, or bones, and the nervous system, is not well understood. 

The Lepper lab studies the mechanics of these processes. overturned previous research that identified critical genes for making muscle stem cells. It turns out that the genes that make muscle stem cells in the embryo are surprisingly not needed in adult muscle stem cells to regenerate muscles after injury. The finding challenges the current course of research into muscular dystrophy, muscle

The Carnegie Hubble program is an ongoing comprehensive effort that has a goal of determining the Hubble constant, the expansion rate of the universe,  to a systematic accuracy of 2%. As part of this program, astronomers are obtaining data at the 3.6 micron wavelength using the Infrared Array Camera (IRAC) on Spitzer Space Telescope. The team has demonstrated that the mid-infrared period-luminosity relation for Cepheids, variable stars used to determine distances and the rate of the expansion,  at 3.6 microns is the most accurate means of measuring Cepheid distances to date. At 3.6 microns, it is possible to minimize the known remaining systematic uncertainties in the Cepheid

What sets George Cody, acting director of the Geophysical Laboratory,  apart from other geochemists is his pioneering use of sophisticated techniques such as enormous facilities for synchrotron radiation, and sample analysis with nuclear magnetic resonance (NMR) spectroscopy to characterize hydrocarbons. Today, Cody  applies these techniques to analyzing the organic processes that alter sediments as they mature into rock inside the Earth and the molecular structure of extraterrestrial organics.

Wondering about where we came from has occupied the human imagination since the dawn of consciousness. Using samples from comets and meteorites, George Cody tracks the element carbon as it

Galacticus is not a super hero; it’s a super model used to determine the formation and evolution of the galaxies. Developed by Andrew Benson, the George Ellery Hale Distinguished Scholar in Theoretical Astrophysics, it is one of the most advanced models of galaxy formation available.

Rather than building his model around observational data, Benson’s Galacticus relies on known laws of physics and the so-called N-body problem, which predicts the motions of celestial bodies that interact gravitationally in groups. Galacticus’ now an open- source model produces results as stunning 3-D videos.

Some 80% of the matter in the universe cannot be seen. This unseen matter is believed

Ronald Cohen primarily studies materials through first principles research—computational methods that begin with the most fundamental properties of a system, such as the nuclear charges of atoms, and then calculate what happens to a material under different conditions, such as pressure and temperature. He particularly focuses on properties of materials under extreme conditions such as high pressure and high temperature. This research applies to various topics and problems in geophysics and technological materials.

Some of his work focuses on understanding the behavior of high-technology materials called ferroelectrics—non-conducting crystals with an electric dipole moment similar

Alan Linde is trying to understand the tectonic activity that is associated with earthquakes and volcanos, with the hope of helping predictions methods.  He uses highly sensitive data that measures how the Earth is changing below the surface with devises called borehole strainmeters that measure tiny strains the Earth undergoes.

Strainmeter data has led to the discovery of events referred to as slow earthquakes that are similar to regular earthquakes except that the fault motions take place over much longer time scales. These were first detected in south-east Japan and have since been seen in a number of different environments including the San Andreas Fault in California and in