Medicinal and biological chemistry

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"Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to help their discoveries become the novel drugs of the future. Often many potentially transformative basic science discoveries are not pursued because they are deemed "too early" to attract industry interest. There are simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest."

New resources on pharmaceutical chemistry

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Carbohydrate chemistry [electronic resource] : state of the art and challenges for drug development : an overview on structure, biological roles, synthetic methods, and application as therapeutics

edited by Laura Cipolla. 2016
In silico medicinal chemistry : computational methods to support drug design

Nathan Brown. 2016
Innovative drug synthesis

edited by Jie Jack Li (University of San Francisco), and Douglas S. Johnson (Pfizer Worldwide Research and Development). 2016
Light-responsive nanostructured systems for applications in nanomedicine [electronic resource]

Salvatore Sortino, editor ; with contributions by S. Acherar... [et al.].. 2016
Synthesis and reactivity of donor-acceptor substituted aminocyclopropanes and aminocyclobutanes

Florian de Nanteuil. 2016

New resources on biochemistry

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Advances in MALDI and laser-induced soft ionization mass spectrometry

Rainer Cramer, editor. 2016
Ambivalences of creating life : societal and philosophical dimensions of synthetic biology

Kristin Hagen, Margret Engelhard, Georg Toepfer, editors. 2016
Biochemistry : concepts and connections

Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews. 2016
Biochemistry : the molecular basis of life

Trudy McKee, James R. McKee. 2016
Carrion ecology, evolution, and their applications

edited by M. Eric Benbow (Michigan State University, East Lansing, USA), Jeffery K. Tomberlin (Texas A&M University, College Station, USA), and Aaron M. Tarone (Texas A&M University, College Station, USA). 2016

New Chem & ChemEng Faculty Publications

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Databases

SciFinder is the most comprehensive database for coverage of chemistry & chemical engineering. It has the world's largest collection of organic and inorganic substance information. The web version of SciFinder provides integrated access to CAPlus, CAS Registry, CASREACT, CHEMLIST, and CHEMCATS which are produced by Chemical Abstracts Service, and to MEDLINE which is produced by the U.S. National Library of Medicine. Sources covered in SciFinder include 10,000 journals, patents from 63 patent authorities, book chapters, conference proceedings, dissertations, evaluated reference works, technical reports, as well as book reviews and biographical information. (Structure and Reaction Searching)

"This on-line work utilizes the full potential of the web by allowing alphanumeric searches through e-EROS and across all Wiley products, and by allowing chemical structure, substructure and reaction searching straight from a chemist's desktop. It contains a database of around 70,000 reactions and around 4000 of the most frequently consulted reagents and is fully searchable by structure and substructure, reagent, reaction type, experimental conditions etc. and allows sophisticated full text searches. e-EROS offers a systematic and exhaustive coverage of reagents used in organic synthesis. The Editorial Board are keeping e-EROS up-to-date by regularly adding new reagents and catalysts, and by updating existing articles whenever felt necessary. The A to Z listing covers classical reagents, new "designer" reagents and catalysts." (Structure Searching)

"PubMed comprises over 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. PubMed citations and abstracts include the fields of biomedicine and health, covering portions of the life sciences, behavioral sciences, chemical sciences, and bioengineering. PubMed also provides access to additional relevant web sites and links to the other NCBI molecular biology resources. PubMed is a free resource that is developed and maintained by the National Center for Biotechnology Information (NCBI), at the U.S. National Library of Medicine (NLM), located at the National Institutes of Health (NIH)."

"Science of Synthesis (SoS) provides a critical review of synthetic methodology developed to-date in the fields of organic and organometallic chemistry. Features include: Selection of molecular transformations by world-renowned experts with elaboration on scope and limitations; Full-text descriptions of synthetic methods with practical experimental procedures immediately applicable in the lab; Community of over 1,000 experts involved in the review and updating of methods; Logical organization of the synthetic methods for each functional group; and Intuitive search functions to allow rapid lead generation and route optimization." Please see Science of Synthesis at Stanford to view online help, learn more about content, and see what's new. (Structure and Reaction Searching)

Search over 12,000 core journals across the sciences, social sciences, and arts and humanities to find the high quality research. Move backward/forward in time using cited/citing reference identified by researchers. Updated weekly, includes Science Citation Index Expanded (1899-present), Social Sciences Citation Index (1898-present), Arts & Humanities Citation Index (1975-present), Conference Proceedings Citation Index- Science (1990-present), Conference Proceedings Citation Index- Social Science & Humanities (1990-present), Book Citation Index (2005-present), Index Chemicus (1993-present), and Current Chemical Reactions (1985-present; also includes Institut National de la Propriete Industrielle structure data back to 1840)). (Structure searching)

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This collection provides a resource for learning, review, and research in medicine and the life sciences. It systematically covers every course in the medical school curriculum and includes basic science volumes of interdisciplinary interest. Packed with illustrations, titles have been used for nearly 50 years by medical students and professionals alike. The innovative electronic version retains the outstanding educational utility of the print books, but incorporates powerful search functions.

Encyclopedias

Representing the current state of a dynamic and crucial field of study, the 2nd edition of this encyclopedia pulls together over 500 articles that help define and explore contemporary biochemistry. It acknowledges that understanding every living process-from physiology, to immunology, and genetics is impossible without a grasp on the basic chemistry that provides its underpinning. Written by experts, each article provides an up-to-date snapshot of a given topic, as well as suggestions for further readings for students and researchers wishing to go into greater depth.

"Available in print and online, this unique reference brings together all four fields of genetics, genomics, proteomics, and bioinformatics to meet your dynamic research requirements. It brings together the latest concepts in these vibrant areas and ensures a truly multidisciplinary approach. Topics include genetic variation and evolution, epigenetics, the human genome, expression profiling, proteome families, structural proteomics, gene finding/gene structure, protein function and annotation, and more. The work incorporates a vast amount of topical information, profiles cutting-edge techniques, and presents the very latest findings from an international team of over five hundred contributors."

Spanning the entire spectrum of the life sciences, ELS is a monthly-updating reference work containing over 4,500 specially commissioned and peer-reviewed articles written by leaders in the field. ELS has articles on these subject areas: Biochemistry, Cell Biology, Developmental Biology, Ecology, Evolution and Diversity of Life, Genetics and Disease, Genetics and Molecular Biology, Immunology, Microbiology, Neuroscience, Plant Science, Science and Society, Structural Biology, and Virology.

"This Encyclopedia offers for the first time a description of free radicals within an interdisciplinary and multidisciplinary context, connecting structural characteristics and chemical properties to their applications in different areas of chemistry and related disciplines, Covering not only basic concepts and chemical synthesis, the Encyclopedia also covers various aspects concerning the role of free radicals in materials and life sciences. The chapters are thematically structured within four areas: Basic Concepts & Methodologies, Synthetic Strategies & Applications, Chemical Biology, and Polymers & Materials."

"Concise but complete, this mini-encyclopedia contains over 1,500 entries covering all important concepts, compounds, techniques and acronyms for quick and easy reference. Guiding readers through the ever-increasing jungle of nucleic acid science and technology, the book distills the key information out of the large body of primary literature and presents it in a single volume. A first-stop resource for everyone, from students to established researchers, as both a desktop and library reference."

Protein Science Encyclopedia , the single most comprehensive knowledge source for protein scientists covers: structure of proteins, function of proteins, analytical methods of proteins, engineering of proteins, and medical aspects of proteins. This encyclopedia contains some 160 articles (corresponding to approx. 4500 printed pages) on fundamental and current topics in 14 subject fields: Transcription and Translation, Technical and Recombinant Synthesis, Modification and Regulation, Damage and Degradation, Structure and Folding, Protein-Ligand Interaction, Protein-Protein Interaction, Enzymatic Function, Engineering and Design, Biotechnology and Bioengineering, Misfolding and Disease, Model Proteins, Structural Analysis, and Functional Analysis."

Handbooks

Version 3.8 features 32 new APIs and a total of 35,358 structures, 11,289 reactions and 2,606 active pharmaceutical ingredients. Essential for research and process chemists, it includes the full synthetic route for the industrial manufacture of each drug elucidated from the patent literature; unique source of reactions that perform on an industrial scale; readily available overview of the pharmaceutical industry from a synthetic chemist’s perspective; and functionality affords insights into a therapeutic area and chemically related substances. Essential information for product managers, it includes patent information including approval date and expiration; determine market size & competition for an API – essential for development of new and generic pharmaceuticals; source of markets for synthesis intermediates; comprehensive coverage of older APIs and substances approved world-wide; and merger and acquisition tracking ensures that vendor information is up-to-date in a rapidly changing industry. (Structure Searching)

"This on-line work utilizes the full potential of the web by allowing alphanumeric searches through e-EROS and across all Wiley products, and by allowing chemical structure, substructure and reaction searching straight from a chemist's desktop. It contains a database of around 70,000 reactions and around 4000 of the most frequently consulted reagents and is fully searchable by structure and substructure, reagent, reaction type, experimental conditions etc. and allows sophisticated full text searches. e-EROS offers a systematic and exhaustive coverage of reagents used in organic synthesis. The Editorial Board are keeping e-EROS up-to-date by regularly adding new reagents and catalysts, and by updating existing articles whenever felt necessary. The A to Z listing covers classical reagents, new "designer" reagents and catalysts." (Structure Searching)

"This two-volume handbook covers 105 major metalloproteins. Content is presented in both a large format and full colour and covers the most relevant transition metals such as iron, nickel, copper, cobalt, molybdenum, manganese tungsten and vanadium. It includes a computer-modelled structure for each compound, with information on the sequence information, synthesis and spectroscopic properties, functional aspects as well as key chemical, biological, physical and medical properties of the compound described. The Handbook of Metalloproteins and the Encyclopedia of Inorganic Chemistry were merged to form the Encyclopedia of Inorganic and Bioinorganic Chemistry. Updates to content will appear in this new encyclopedia"

Porphyrins, phthalocyanines and their numerous analogues and derivatives are materials of tremendous importance in chemistry, materials science, physics, biology and medicine. They are the red color in blood (heme) and the green in leaves (chlorophyll); they are also excellent ligands that can coordinate with almost every metal in the Periodic Table. This handbook will prove to be a modern authoritative treatise on the subject as it is a collection of up-to-date works by world-renowned experts in the field.

Methods & Protocols

Springer Protocols is the largest subscription-based electronic database of reproducible laboratory protocols in the Life and Biomedical Sciences. Compiling protocols from Humana’s successful book series Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, and Neuromethods, as well as from a vast number of Laboratory Handbooks, such as The Biomethods Handbook, The Proteomics Handbook, and the Springer Laboratory Manuals.

Major Reference Works

Burger's offers easy access to broad coverage of medicinal chemistry and drug discovery for new, as well as experienced, medicinal chemists, biologists, pharmacologists, and molecular biologists. Burger's offers a comprehensive, global perspective of drug design and drug development. With expanded content, this edition of Burger’s Medicinal Chemistry and Drug Discovery includes more than 50% new material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science including: proteomics, genomics, bioinformatics, combinatorial chemistry, high-throughput screening, blood substitutes, allosteric effectors as potential drugs, COX inhibitors, statins, high-throughput pharmacology, and much more.

"Biomaterials is a dynamic, changing field that impacts modern medicine and therapeutics in diverse ways. This modern, all-encompassing comprehensive treatment accurately captures the diversity, breadth and dimensions of the biomaterials field. It describes the many modern aspects of biomaterials - from basic science to clinical applications - across the formulations and chemistry of polymers, ceramics and metals and their use in various biomedical devices and implants, as well as their clinical performance and host responses. Conventional clinically accepted biomaterials as well as emerging prototypes, studies and new ideas, along with visionary predictions of future biomaterials compositions and capabilities, are all extensively covered by hundreds of experts in the field."

Comprehensive Biophysics provides definitive introductions to a broad array of topics, uniting different areas of biophysics research, from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource: a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge.

Comprehensive Biotechnology 2nd Edition is an integrated compendium of six volumes covering all the essential elements of the field. The first two volumes provide the basics of the underlying scientific and engineering principles of biotechnology; the following four volumes treat the major application branches that impact industry, agriculture, medicine and environment.v. 1. Scientific fundamentals of biotechnology. v. 2. Engineering fundamentals of biotechnology. v. 3. Industrial biotechnology and commodity products. v. 4. Agricultural and related biotechnologies. v. 5. Medical biotechnology and healthcare. v. 6. Environmental biotechnology and safety

Comprehensive Chirality provides a complete overview of the field and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the nine volumes provide an in-depth review and collection of references on definition, technology, applications and a guide/links to the related literature. v. 1: Biological Significance: Pharmacology, Phamaceutical Agrochemical. v. 2: Synthetic Methods I: Chiral Pool and Diastereoselective Methods. v. 3: Synthetic Methods II: Chiral Auxiliaries. v. 4: Synthetic Methods III: Catalytic Methods: C–C Bond Formation. v. 5: Synthetic Methods IV: Asymmetric Oxidation Reduction, C–N. v. 6: Synthetic Methods V: Organocatalysis. v. 7: Synthetic Methods VI: Enzymatic and Semi-Enzymatic. v. 8: Separations and Analysis. v. 9: Industrial Applications of Asymmetric Synthesis

"Carbohydrates are an important part of life and are present in bacteria, fungi, viruses, yeast, plants, animals and humans. This work has a very broad scope and will appeal to a wide audience as it explores the interactions between biology, chemistry and molecular biology towards understanding, synthesising and developing glycoproteins, glycolipids, proteoglyans and polysaccharides, which are important molecules in nature for controlling health and disease and food and feed. Glycocompounds reviewed include: oligosaccharides, polysaccharides, glycoproteins, glycolipids, glycoconjugates, lectins, cellulose, pectins and starch.Topics covered include: spectroscopy, nomenclature, structures, synthesis, biosynthesis, molecular interactions, degradation, biochemistry, glycobiology, glycotherapeutics and diseases."

Contents: v1. Polyketides and other secondary metabolites including fatty acids and their derivatives; v2. Isoprenoids including carotenoids and steroids ; v3. Carbohydrates and their derivatives including tannins, cellulose, and related lignins; v4. Amino acids, peptides, porphyrins, and alkaloids; v5. Enzymes, enzyme mechanisms, proteins, and aspects of NO chemistry; v6. Prebiotic chemistry, molecular fossils, nucleosides, and RNA; v7. DNA and aspects of molecular biology; v8. Miscellaneous natural products including marine natural products, pheromones, plant hormones, and aspects of ecology.

Emphasizing synthetic strategy and practice, this online reference work features experimental procedures for stereoselective synthetic reactions applicable to drug targets and natural products. The reference details synthetic methodology, reaction mechanisms, and applications for medicinal chemistry and drug discovery; and explores strategy and interdisciplinary work, laboratory synthesis for natural products, the preparative aspects of stereoselective synthesis for drugs, natural products, and potential biologically active compounds.

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Medicinal and biological chemistry

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Related guides

Around Stanford

Table of Contents

Home

New resources on pharmaceutical chemistry

New resources on biochemistry

New Chem & ChemEng Faculty Publications

Futurity: news from leading research universities

Databases

Journals

Finding Journals

Books

Encyclopedias

Handbooks

Methods & Protocols

Major Reference Works

Reference Shelf

Software

Site-licensed by Swain Library

Software, apps, and widgets

Websites

Calendars: Meetings and events