Bookmarking. Sad to see such a helpful account leaving twitter.com/k_g_andersen/s
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Meg Tirrell
@megtirrell
Meg Tirrell’s Tweets
Former Theranos COO Sunny Balwani sentenced to nearly 13 years in prison
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Flu data out today. Holy crap.
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Ok parents how the heck do you get your baby to allow you to administer the NoseFrida?
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Former Theranos CEO Elizabeth Holmes sentenced to more than 11 years in prison
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Was wondering about this!
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Was surprised to see the name of Lillys new experimental Alzheimer’s antibody — remternetug — didn’t end in “mab,” as all antibody drugs do
Learned that, apparently, the 3-decade era of “mab” ended last year, as scientists just ran out of new names(???)
ncbi.nlm.nih.gov/pmc/articles/P
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Covid rates have been uniformly good in the U.S., but there IS geographic variation. For example, I'm OK eating indoors in SF now (7 cases/100K/d). But I'm heading to NYC this Friday, and I won't (29 cases/100K/d). Why? The same encounter there is 4x riskier Covid-wise than here.
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Pfizer $PFE says vaccine to prevent RSV in newborns is effective statnews.com/2022/11/01/pfi via $GSK
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For anyone who needs it, this soup recipe is my new go-to for getting through daycare colds (on #2 of infinity 😩🤧). The ginger, kale & broccoli = perfection
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It’s happening! Just days to go before #whenwomenlead comes out! Pre-order now! instagram.com/p/CjeFhrapE-a/
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MA COVID wastewater levels took a big jump in recent days - no state case/hospitalization reports since Thurs given weekly state reporting. But it’s clear that we are on a rapid upswing. Plan accordingly.
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Lecanemab data are unambiguously statistically positive. 0.45 advantage on 18-point scale, where MCID is 0.5-1.0 points, will now be the subject of furious debate. Scientifically, this is wonderful news. Clinically and practically, it’s going to be very difficult.
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BREAKING --> $ESALY $BIIB Alzheimer’s treatment slowed cognitive decline in closely watched clinical trial statnews.com/2022/09/27/alz The lecanemab results from CLARITY-AD
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Um no I did not leave “adult sleep bag walker in midnight” in my cart
It was in fuschia
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New US variant update:
➡️~97% of COVID due to BA.4/5 subvariants
➡️Other Omicron subvariants (BA.2.75, BF.7) newly listed at low levels
✅Updated bivalent vaccines target BA.4/5/original strain, and broaden protection across Omicron subvariants
✅Get one to maximize protection!
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‘Papadopoulos declined requests to be interviewed for this story. “I have flaws,” he wrote in an email to STAT, “but vanity is not one of them.”’ ’s profile of biotech’s godfather is a must-read
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Signs you’re a biotech journalist: your phone autocorrects “r&r” to “r&d”
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Loved this peek into the brain of the wonderful Henry Reisch on the future of TV news
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Of all the things I thought would happen while I was out on maternity leave, this was not one of them
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President Biden is on the verge of his own crowning health care achievement to call, in his words, a BFD. After two decades, Democrats are finally on track to break the firewall between the pharmaceutical industry and the Medicare program.
statnews.com/2022/08/07/med
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More evidence of #poliovirus spread in counties North of NYC. Wastewater sample from 2 counties with dismal vaccination rates were positive for polioviruses in June & July, NYS Dept of Health reports.
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In a call with investors this morning
announced that has, for its contract of Omicron BA.4/5 bivalent booster shots for the fall
"exercised an option for 4 million doses for the pediatric age group"
getrevue.co/profile/alexan
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Today, we’re reporting second quarter 2022 financial results and providing business updates. Read more: investors.modernatx.com/news/default.a
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Biden tests positive for Covid again, will restart isolation despite no new symptoms
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Latest estimates: BA.4 (~13%) and BA.5 (~82%) comprised ~95% of sequenced specimens last week. BA.5 more than 75% in all regions of the country. covid.cdc.gov/covid-data-tra
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More than half of all states have or are planning to impose new anti-abortion laws. Some of them have just one exception and that exception is causing confusion in the medical community. reports.
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Moderna and Pfizer's work so far was on boosters containing BA.1, the original version of omicron - they said Tuesday it would take until early Oct (Pfizer) or early Nov (Moderna) to be able to manufacture enough at scale of new boosters focusing on BA.4/5
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FDA says it advised #covid19 vaccine manufacturers to make bivalent boosters including BA.4/5 protection for potential use in early to mid-fall 2022:
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Pfizer & BioNTech announce $3.2B supply agreement for 105M more doses of #covid19 vaccine to US govt (30, 10 & 3mcg doses), which may include adult omicron-adapted vaccines, subject to FDA authorization, planned for delivery between late summer & into fourth quarter.
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Lilly to provide additional 150K doses of #covid19 antibody treatment bebtelovimab to US govt for $275m:
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It’s officially time to update booster shots. That’s the new, long-awaited recommendation from a key advisory panel. The goal is to improve vaccine effectiveness and in turn prevent another surge in infections. breaks down the decision.
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The U.S. is increasing access to #monkeypox vaccine, making the vaccine available to MSM who have recently had multiple partners in a venue or at an event where #MPXV is known to have been spreading or in an area where the virus is spread.
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Anthony Fauci says that he's experienced a rebound in Covid symptoms after taking a course of Pfizer Inc.'s antiviral Paxlovid.
The NIAID director, speaking at #FPGlobalHealth, says he's currently on his second course of the treatment. He tested + then - and then + again.
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FDA advisory panel votes: does committee recommend inclusion of SARS-CoV-2 omicron component for #covid19 booster vaccines in the U.S.?
Yes: 19
No: 2
Abstain: 0
(Did not specify which version of omicron, but most committee members appeared to lean toward BA.4/5 vs BA.1)
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Seeing that BA.4 & 5's spikes are identical, so that would explain it!
"BA.4 and BA.5 differ from one another in mutations that are outside of the spike gene but they are identical to each other in terms of spike mutations (1,2)."
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FDA advisory committee is debating whether #covid19 boosters should be updated for the fall to bivalent (combo) of original strain and BA.4/5 - but would they include either BA.4 OR BA.5, or both? (Wouldn't both, plus original strain, be a trivalent vaccine?)
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Great BA.5 primer by . Key points:
1) Will be dominant variant soon
2) ⬆infectious & ⬆immune evasive vs prior variants
3) Severity unclear, but some ⬆hospitalizations
4) Adds to case for 2nd boost & masking
5) New bivalent vax may not add much
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Meanwhile, FDA advisory committee is currently discussing updated vaccines including BA.1 spike
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Just updated:
BA.4 & BA.5 estimated to comprise the majority (~52%) of sequences last week in the US
These variants are growing in all regions of the country
Similar growth of BA.4 & BA.5 seen in multiple countries around the world.
Nowcast here: covid.cdc.gov/covid-data-tra
BA.4 & BA.5 estimated to comprise the majority (~52%) of sequences last week in the US
These variants are growing in all regions of the country
Similar growth of BA.4 & BA.5 seen in multiple countries around the world.
Nowcast here: covid.cdc.gov/covid-data-tra
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Moderna's Dr Stephen Hoge says they expect data from pediatric studies on bivalent boosters by the middle of the fall
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